Gregory L May

US Patent:

6635447, Oct 21, 2003

Filed:

Aug 7, 2000

Appl. No.:

09/633739

Inventors:

Orla M. Conneely - Houston TX
Denis R. Headon - Galway, IE
Bert W. OMalley - Houston TX
Gregory S. May - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12P 2106

US Classification:

435 691, 435 6, 4352522, 4352402, 4353201

Abstract:

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product. The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.

US Patent:

6906243, Jun 14, 2005

Filed:

Dec 20, 2001

Appl. No.:

10/029065

Inventors:

Peter B. Kipp - Houston TX, US
Gregory D. May - Ardmore OK, US
Pramod B. Mahajan - Urbandale IA, US
Christopher L. Baszczynski - Urbandale IA, US
Tong Zhu - Chapel Hill NC, US

Assignee:

Boyce Thompson Institute for Plant Research - Ithaca NY
Pioneer Hi-Bred International, Inc. - Des Moines IA

International Classification:

A01H001/00
A01H005/00
A01H005/10
C12N015/29
C12N015/82

US Classification:

800298, 4353201, 435419, 536 236, 800278, 800286

Abstract:

The invention relates to isolated nucleic acid molecules encoding MutS homologues (MSHs). Such MSH proteins are involved in DNA mismatch-repair processes in organisms. The invention provides isolated nucleic acid molecules comprising MSH2 nucleotide sequences which encode MSH2 proteins and MSH2 nucleotide sequences which encode dominant-negative MSH2 variants. Such MSH2 nucleotide sequences find use in altering mismatch repair, mutation rates and recombination frequencies in both eukaryotic and prokaryotic organisms. The invention also provides isolated nucleic acid molecules comprising MSH2 promoter nucleotide sequences. Such MSH2 promoter nucleotide sequences find use in regulating the expression of genes of interest in plants. Additionally provided are isolated proteins, transformed host cells, and transformed plants, tissues, cells and seeds thereof.

US Patent:

20050009051, Jan 13, 2005

Filed:

Apr 22, 2004

Appl. No.:

10/829661

Inventors:

Xiang-Yang Han - Bellaire TX, US
Jeffrey Tarrand - Houston TX, US
Audrey Pham - Houston TX, US
Gregory May - Houston TX, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The present invention provides methods for detecting the presence of pathogenic moulds in biological samples that are based on amplification of mould nucleic acids. The methods may further comprise quantitating and real time detection of the mould. The methods of the invention are highly specific and do not co-amplify human or other yeast nucleic acids. The methods of the invention are also extremely sensitive. Thus, methods for diagnosing infections caused by mould are provided. The invention also provides kits for detection of moulds.

US Patent:

20050048509, Mar 3, 2005

Filed:

Sep 26, 2003

Appl. No.:

10/672300

Inventors:

Xiang-Yang Han - Bellaire TX, US
Jeffrey Tarrand - Houston TX, US
Audrey Pham - Houston TX, US
Gregory May - Houston TX, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

The present invention provides methods for detecting the presence of invasive pathogenic molds in biological samples that are based on amplification of mold nucleic acids. The methods may further comprise quantitating and real time detection of the invasive mold. The methods of the invention are highly specific and do not co-amplify human or other yeast nucleic acids. The methods of the invention are also extremely sensitive. Thus, methods for diagnosing infections caused by invasive mold are provided. The invention also provides kits for detection of invasive molds.

US Patent:

20050064546, Mar 24, 2005

Filed:

Jul 15, 2003

Appl. No.:

10/620256

Inventors:

Orla Conneely - Houston TX, US
Denis Headon - Galway, IE
Bert O'Malley - Houston TX, US
Gregory May - Houston TX, US

International Classification:

C07H021/04
C12N009/02
C12N009/32
C12N001/16
C12N001/18
C12N005/06
C12N015/74

US Classification:

435069100, 435189000, 435204000, 435254200, 435254300, 435348000, 435320100, 536023200

Abstract:

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.

US Patent:

55716911, Nov 5, 1996

Filed:

Oct 28, 1993

Appl. No.:

8/145681

Inventors:

Orla M. Conneely - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Gregory S. May - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12N 1512
C12N 1579
C12N 1585
C07K 1479

US Classification:

435 691

Abstract:

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product. The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.

US Patent:

58498818, Dec 15, 1998

Filed:

May 30, 1995

Appl. No.:

8/456106

Inventors:

Orla M. Conneely - Houston TX
Denis R. Headon - Galway, IE
Bert W. O'Malley - Houston TX
Gregory S. May - Houston TX

International Classification:

C07K 1479
C07K 14435
C12N 1580
C12N 1581

US Classification:

530400

Abstract:

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product. The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.

US Patent:

62286145, May 8, 2001

Filed:

Mar 9, 1999

Appl. No.:

9/265577

Inventors:

Orla M. Conneely - Houston TX
Denis R. Headon - Houston TX
Bert W. O'Malley - Houston TX
Gregory S. May - Houston TX

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12N 1509
C12N 1579
C12N 1580
C12N 1512
C07K 1479

US Classification:

435 691

Abstract:

The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA such as the Fe binding sites can be used to make an hLF polypeptide product. The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for lactoferrin protein. Methods for the production of lactoferrin protein in fungi and bacteria are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant lactoferrin protein and lactoferrin related polypeptides.

Address:

24327 Yelverton Gln Dr, Katy, TX 77493

VIN:

1G1YY26U275136220

Make:

CHEVROLET

Model:

CORVETTE

Year:

2007