Gregory B Ray

US Patent:

6372712, Apr 16, 2002

Filed:

May 21, 1999

Appl. No.:

09/316932

Inventors:

Roger Briesewitz - Mountain View CA
Gerald R. Crabtree - Woodside CA
Thomas Wandless - Menlo Park CA
Gregory Thomas Ray - Stanford CA
Kurt William Vogel - Palo Alto CA

Assignee:

The Board of Trustees of the Leland Stanford Jr. University - Palo Alto CA
The Howard Hughes Medical Institute - Chevy Chase MD

International Classification:

A61K 3800

US Classification:

514 2, 424 941, 424 945, 435177, 514 9, 530402, 530812

Abstract:

Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is preferably less than about 5000 daltons, and the drug moiety may have a molecular weight of from about 50 to 2000 daltons. The drug moiety and presenter protein ligand may be covalently linked directly or through a linking group. The drug moiety binds to a drug target such as a protein and the presenter protein ligand binds to a presenter protein that is not the drug target such as extracellular or intracellular protein. Presenter proteins include peptidyl prolyl isomerase (FKBP), Heat Shock Protein 90 (Hsp90), steroid hormone receptors, cytoskeletal proteins, albumin and vitamin receptors. When the presenter protein is FKBP, ligands include FK506, rapamycin and cyclosporin A which may have an introduced functional group such as hydroxyl, amino, carboxyl, aldehyde, carbonate, carbamate, azide, thiol or ester for attaching the drug moiety. In the methods of use, an effective amount of the bifunctional molecule is administered to the host.

US Patent:

6921531, Jul 26, 2005

Filed:

Dec 21, 2001

Appl. No.:

10/025936

Inventors:

Roger Briesewitz - Mountain View CA, US
Gerald R. Crabtree - Woodside CA, US
Thomas Wandless - Menlo Park CA, US
Gregory Thomas Ray - Stanford CA, US
Kurt William Vogel - Palo Alto CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
Howard Hughes Medical Institute - Chevy Chase MD

International Classification:

A61K038/52
A61K038/00
C12N011/02
C07K001/00
C07K017/02

US Classification:

424 945, 424 941, 514 2, 514 9, 435177, 530402, 530812

Abstract:

Bifunctional molecules and methods for their use in the production of binary or tripartite complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is less than about 5000 daltons. In the methods, an effective amount of the bifunctional molecule is administered to the host. In certain embodiments the bifunctional molecule binds to the presenter protein and a drug target to produce a tripartite complex, while in other embodiments the bifunctional molecule binds to either the presenter protein or the drug target, but not both, to produce a binary complex The subject methods and compositions find use in a variety of therapeutic applications.

US Patent:

7390784, Jun 24, 2008

Filed:

Dec 13, 2004

Appl. No.:

11/011499

Inventors:

Roger Briesewitz - Mountain View CA, US
Gerald R. Crabtree - Woodside CA, US
Thomas Wandless - Menlo Park CA, US
Gregory Thomas Ray - Stanford CA, US
Kurt W. Vogel - Palo Alto CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61K 38/00
A61K 38/52
C12N 11/02
C07K 1/00
C07K 17/02

US Classification:

514 2, 424 941, 424 945, 435177, 514 9, 530402, 530812

Abstract:

Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional molecule is administered to the host. The bifunctional molecule binds to the presenter protein to produce a binary complex that exhibits at least one of improved affinity, specificity or selectivity as compared to the corresponding free drug. The subject methods and compositions find use in a variety of therapeutic applications.

US Patent:

20220297129, Sep 22, 2022

Filed:

Jul 27, 2020

Appl. No.:

17/630048

Inventors:

- San Francisco CA, US
Gregory Arthur RAY - San Francisco CA, US
Foteini CHRISTODOULOU - San Francisco CA, US

Assignee:

MIROCULUS INC. - San Francisco CA

International Classification:

B01L 3/00

Abstract:

Digital microfluidic (DMF) apparatuses and methods for optically-induced heating and manipulating droplets are described herein. DMF apparatuses employing photonic heating as described herein provide radical simplification of routing droplets/reagents in complex, multistep protocols and/or highly plexed workflows.

US Patent:

20220250078, Aug 11, 2022

Filed:

Apr 25, 2022

Appl. No.:

17/728952

Inventors:

- San Francisco CA, US
Ik Pyo HONG - Toronto, CA
Jair Giovanny BELTRAN-VERA - Bogota, CO
Juan Matias DeCARLI - San Francisco CA, US
Mais Jehan JEBRAIL - Toronto, CA
Gregory RAY - San Francisco CA, US
Mathieu Gabriel-Emmanuel CHAULEAU - San Francisco CA, US
Paul Mathew LUNDQUIST - Emeryville CA, US
Alejandro TOCIGL - Mountain View CA, US
John Peter CANNISTRARO - San Francisco CA, US
Gareth SCOTT - San Francisco CA, US
Spencer SEILER - San Francisco CA, US
Rohit LAL - San Francisco CA, US
Eugenia CARVAJAL - San Francisco CA, US
Eduardo CERVANTES - San Francisco CA, US
Nikolay SERGEEV - San Francisco CA, US
Yu-Hung CHEN - San Francisco CA, US
Foteini CHRISTODOULOU - San Francisco CA, US

International Classification:

B01L 3/00
C12M 3/06
C12M 1/00
H01L 21/768

Abstract:

Digital microfluidic (DMF) methods and apparatuses (including devices, systems, cartridges, DMF readers, etc.), and in particular DMF apparatuses and methods adapted for large volume. For example, described herein are methods and apparatuses for DMF using an air gap having a width of the gap that may be between 0.3 mm and 3 mm. Also described herein are DMF readers for use with a DMF cartridges, including those adapted for use with large air gap/large volume, although smaller volumes may be used as well.

US Patent:

20220219172, Jul 14, 2022

Filed:

Feb 28, 2020

Appl. No.:

17/434531

Inventors:

- San Francisco CA, US
Mais Jehan JEBRAIL - Toronto, CA
Alejandro TOCIGL - Mountain View CA, US
Foteini CHRISTODOULOU - San Francisco CA, US
Carl David MARTIN - Livermore CA, US
Morgan Marin WATSON - Oakland CA, US
Rohit LAL - San Francisco CA, US
Joshua SHEN - Union City CA, US
Ronan Barry HAYES - San Francisco CA, US
Gregory Arthur RAY - San Francisco CA, US
Peter Tirtowijoyo YOUNG - Berkeley CA, US
Spencer Todd SEILER - San Francisco CA, US
Ik Pyo HONG - Toronto, CA
Mohan GURUNATHAN - San Francisco CA, US
Lubomir DALTCHEV - Sunnyvale CA, US
Juan Matias de CARLI - Buenos Aires, AR
Jobelo Andres Quintero RODRÍGUEZ - Bogota, CO
Matias Jorge LESCANO - Buenos Aires, AR

Assignee:

MIROCULUS INC. - San Francisco CA

International Classification:

B01L 3/00

Abstract:

Digital microfluidic (DMF) methods and apparatuses (including devices, systems, cartridges, DMF readers, etc.), and in particular DMF apparatuses and methods that may be used to safely manually add or remove fluid within a cartridge while it is actively applying DMF. Also described herein are DMF readers for use with a DMF cartridges, including those including multiple and/or redundant safety interlocks. Also described herein are DMF reader devices having a cover with active control of microfluidics on the cover while actively controlling DMF on the reader base.

US Patent:

20200006720, Jan 2, 2020

Filed:

Jun 28, 2019

Appl. No.:

16/455962

Inventors:

- Pleasanton CA, US
Jesse Gage - Pleasanton CA, US
Gregory Ray - Pleasanton CA, US
Ethan Petersen - Pleasanton CA, US
Jaime Romero - Pleasanton CA, US

International Classification:

H01M 2/06
H01M 10/04
H01M 2/20
H01M 2/30
H01M 2/10
H05K 3/32
H05K 3/36

Abstract:

The present disclosure is directed to an electrochemical cell connector for electrically connecting a plurality of electrochemical cells, and to battery packs including the electrochemical cell connector. The electrochemical cell connectors of the present disclosure are fabricated from a flexible circuit. The flexible circuit includes conductors, such as nickel conductors, soldered or otherwise attached thereto via holes or openings in the flexible circuit. These conductors may be welded or otherwise attached to an electrochemical cell, and the electrochemical cell connections made on the flexible circuit. In many embodiments, the conductors may be attached to the flexible circuit using industry standard automated assembly equipment thus streamlining the manufacturing process and improving overall quality of the product.

US Patent:

20190168223, Jun 6, 2019

Filed:

Jan 28, 2019

Appl. No.:

16/259984

Inventors:

- San Francisco CA, US
Ik Pyo HONG - Toronto, CA
Jair Giovanny BELTRAN-VERA - Bogota, CO
Juan Matias DeCARLI - San Francisco CA, US
Mais Jehan JEBRAIL - Toronto, CA
Gregory RAY - San Francisco CA, US
Mathieu Gabriel-Emmanuel CHAULEAU - San Francisco CA, US
Paul Mathew LUNDQUIST - Emeryville CA, US
Alejandro TOCIGL - Mountain View CA, US
John Peter CANNISTRARO - San Francisco CA, US
Gareth SCOTT - San Francisco CA, US
Spencer SEILER - San Francisco CA, US
Rohit LAL - San Francisco CA, US
Eugenia CARVAJAL - San Francisco CA, US
Eduardo CERVANTES - San Francisco CA, US
Nikolay SERGEEV - San Francisco CA, US
Yu-Hung CHEN - San Francisco CA, US
Foteini CHRISTODOULOU - San Francisco CA, US

International Classification:

B01L 3/00

Abstract:

Digital microfluidic (DMF) methods and apparatuses (including devices, systems, cartridges, DMF readers, etc.), and in particular DMF apparatuses and methods adapted for large volume. For example, described herein are methods and apparatuses for DMF using an air gap having a width of the gap that may be between 0.3 mm and 3 mm. Also described herein are DMF readers for use with a DMF cartridges, including those adapted for use with large air gap/large volume, although smaller volumes may be used as well.