Gregory A Stein

US Patent:

7582468, Sep 1, 2009

Filed:

Mar 1, 2006

Appl. No.:

11/365275

Inventors:

Nigel Ian Bowers - Yardley PA, US
Paul M. Skonezny - Baldwinsville NY, US
Gregory L. Stein - Mallory NY, US
Thomas Franceschini - Cicero NY, US
Shu-Jen Chiang - Manlius NY, US
Wendy L. Anderson - Mexico NY, US
Li You - Jamesville NY, US
Zizhuo Xing - Syracuse NY, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12P 41/00

US Classification:

435280, 435155

Abstract:

The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized having ATCC deposit no. PTA-6648.

US Patent:

20090286303, Nov 19, 2009

Filed:

Jul 21, 2009

Appl. No.:

12/506596

Inventors:

Nigel Ian Bowers - Yardley PA, US
Paul M. Skonezny - Baldwinsville NY, US
Gregory L. Stein - Mallory NY, US
Thomas Franceschini - Cicero NY, US
Shu-Jen Chiang - Manlius NY, US
Wendy L. Anderson - Mexico NY, US
Li You - Jamesville NY, US
Zizhuo Xing - Syracuse NY, US

International Classification:

C12N 1/21

US Classification:

4352523

Abstract:

The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized having ATCC deposit no. PTA-6648.

Address:

4040 Rosemonte Dr, Allison Park, PA 15101

Phone:

(412)3229144

VIN:

KNDJT2A24A7071069

Make:

KIA

Model:

SOUL

Year:

2010