Guillaume Lessard

US Patent:

7247842, Jul 24, 2007

Filed:

Jul 12, 2005

Appl. No.:

11/180976

Inventors:

Stephen R. Quake - San Marino CA, US
Guillaume Lessard - Rochester NY, US
Lawrence A. Wade - La Canada CA, US
Jordan M. Gerton - Upland CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

H01J 3/14
H01J 40/14
H01J 5/16

US Classification:

250234, 2504581

Abstract:

Methods and systems for operating an apertureless microscope for observing one or more features to a molecular sensitivity on objects are described. More particularly, the method includes moving a tip of a probe coupled to a cantilever in a vicinity of a feature of a sample, which emits one or more photons at a detected rate relative to a background rate of the sample based upon the presence of the tip of the probe in the vicinity of the feature. The method modifies the detected rate of the feature of the sample, whereupon the modifying of the detected rate causes the feature of the sample to enhance relative to background rate of the feature.

US Patent:

7498551, Mar 3, 2009

Filed:

Oct 6, 2006

Appl. No.:

11/544988

Inventors:

James H. Werner - Los Alamos NM, US
Peter M. Goodwin - Los Alamos NM, US
Guillaume Lessard - Santa Fe NM, US

Assignee:

Los Alamos National Security, LLC - Los Alamos NM

International Classification:

G01N 21/64

US Classification:

2502032, 2502013

Abstract:

An apparatus and method were used to track the movement of fluorescent particles in three dimensions. Control software was used with the apparatus to implement a tracking algorithm for tracking the motion of the individual particles in glycerol/water mixtures. Monte Carlo simulations suggest that the tracking algorithms in combination with the apparatus may be used for tracking the motion of single fluorescent or fluorescently labeled biomolecules in three dimensions.

US Patent:

20190076182, Mar 14, 2019

Filed:

Nov 8, 2018

Appl. No.:

16/184443

Inventors:

- Mansfield MA, US
GUILLAUME LESSARD - LOUISVILLE CO, US
RICHARD M. FERRELL - ALEXANDRIA VA, US

International Classification:

A61B 18/14
A61B 18/00
A61B 18/12

Abstract:

A method of sealing tissue includes providing an end effector assembly including first and second jaw members. One or both of the jaw members includes an interior electrode and one or both of the jaw members includes first and second exterior electrodes disposed on either side of the interior electrode. The method further includes grasping tissue between the first and second jaw members and conducting energy between the interior and exterior electrodes to seal tissue grasped between the first and second jaw members. During tissue sealing, tissue disposed adjacent the exterior electrodes boils faster than tissue disposed adjacent the interior electrodes.

US Patent:

20180250067, Sep 6, 2018

Filed:

May 4, 2018

Appl. No.:

15/971853

Inventors:

- Mansfield MA, US
GUILLAUME LESSARD - LOUISVILLE CO, US
RICHARD M. FERRELL - ALEXANDRIA VA, US

International Classification:

A61B 18/14
A61B 18/12
A61B 18/00

Abstract:

An end effector assembly for an electrosurgical device includes first and second jaw members movable between spaced-apart and approximated positions. The jaw members include tissue-contacting surfaces that define a tissue grasping area. One of the jaw members includes an electrically-insulating body, an interior electrode, and an exterior electrode. The interior electrode is positioned interiorly of outer bounds of the tissue grasping area. A portion of the interior electrode forms part of the tissue-contacting surface. The exterior electrode is positioned exteriorly of the outer bounds of the tissue grasping area. At least one portion of the exterior electrode: extends along the outer back surface of the body, is disposed within the body, and is positioned adjacent the outer bounds of the tissue grasping area. The interior and exterior electrodes are configured to conduct energy through tissue grasped within the tissue grasping area to seal tissue.

US Patent:

20150282867, Oct 8, 2015

Filed:

Dec 3, 2014

Appl. No.:

14/558988

Inventors:

- MANSFIELD MA, US
GUILLAUME LESSARD - LOUISVILLE CO, US
RICHARD M. FERRELL - DENVER CO, US

International Classification:

A61B 18/14

Abstract:

An end effector assembly for an electrosurgical device includes first and second jaw members movable between spaced-apart and approximated positions. The jaw members define opposed tissue-contacting surfaces that cooperate to define a tissue grasping area within which tissue is grasped when the jaw members are moved to the approximated position. At least one of the jaw members includes an interior electrode and at least one of the jaw members includes first and second exterior electrodes. The interior and exterior electrodes are configured to conduct energy through tissue grasped within the tissue grasping area to seal tissue. The interior electrodes are disposed interiorly of outer bounds of the tissue grasping area, while the exterior electrodes are disposed exteriorly. As a result, upon conduction of energy through tissue grasped within the tissue grasping area, tissue disposed adjacent the exterior electrodes is boiled before boiling of tissue disposed adjacent the interior electrodes.

US Patent:

20150282868, Oct 8, 2015

Filed:

Dec 3, 2014

Appl. No.:

14/559032

Inventors:

- MANSFIELD MA, US
GUILLAUME LESSARD - LOUISVILLE CO, US
RICHARD M. FERRELL - DENVER CO, US

International Classification:

A61B 18/14

Abstract:

An end effector assembly for an electrosurgical device includes first and second jaw members movable between spaced-apart and approximated positions for grasping tissue therebetween. The jaw members cooperate to define a tissue grasping area. One or both of the jaw members includes an inner electrode. One or both of the jaw members includes first and second outer electrodes disposed on either side of the inner electrode. The inner and outer electrodes are configured to conduct energy through tissue grasped within the tissue grasping area to seal tissue. The inner and outer electrodes define different configurations such that, upon conduction of energy through tissue grasped within the tissue grasping area, tissue disposed adjacent the outer electrodes is boiled before boiling of tissue disposed adjacent the inner electrodes.

US Patent:

20150282869, Oct 8, 2015

Filed:

Dec 3, 2014

Appl. No.:

14/559273

Inventors:

- MANSFIELD MA, US
GUILLAUME LESSARD - LOUISVILLE CO, US
RICHARD M. FERRELL - DENVER CO, US

International Classification:

A61B 18/14

Abstract:

An end effector assembly for an electrosurgical device includes first and second jaw members movable between spaced-apart and approximated positions. The jaw members include tissue-contacting surfaces that define a tissue grasping area. One of the jaw members includes an electrically-insulating body, an interior electrode, and an exterior electrode. The interior electrode is positioned interiorly of outer bounds of the tissue grasping area. A portion of the interior electrode forms part of the tissue-contacting surface. The exterior electrode is positioned exteriorly of the outer bounds of the tissue grasping area. At least one portion of the exterior electrode: extends along the outer back surface of the body, is disposed within the body, and is positioned adjacent the outer bounds of the tissue grasping area. The interior and exterior electrodes are configured to conduct energy through tissue grasped within the tissue grasping area to seal tissue.

US Patent:

20150282870, Oct 8, 2015

Filed:

Dec 3, 2014

Appl. No.:

14/559410

Inventors:

- MANSFIELD MA, US
GUILLAUME LESSARD - LOUISVILLE CO, US
RICHARD M. FERRELL - DENVER CO, US

International Classification:

A61B 18/14

Abstract:

A method of sealing tissue includes providing an end effector assembly including first and second jaw members. One or both of the jaw members includes an interior electrode and one or both of the jaw members includes first and second exterior electrodes disposed on either side of the interior electrode. The method further includes grasping tissue between the first and second jaw members and conducting energy between the interior and exterior electrodes to seal tissue grasped between the first and second jaw members. During tissue sealing, tissue disposed adjacent the exterior electrodes boils faster than tissue disposed adjacent the interior electrodes.