Guoqing Chen

US Patent:

20110086834, Apr 14, 2011

Filed:

Jun 26, 2009

Appl. No.:

12/997868

Inventors:

Guoqing Chen - Palo Alto CA, US
Timothy D. Cushing - Pacifica CA, US
Paul Faulder - Cheshire, GB
Benjamin Fisher - San Mateo CA, US
Xiao He - Foster City CA, US
Kexue Li - Mountain View CA, US
Zhihong Li - Millbrae CA, US
Wen Liu - Foster City CA, US
Lawrence R. Mcgee - Pacifica CA, US
Vatee Pattaropong - Burlingame CA, US
Jennifer L. Seganish - Scotch Plains NJ, US
Youngshook Shin - Emeryville CA, US
Zhulun Wang - Palo Alto CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

A61K 31/506
C07D 413/14
C07D 403/14
C07D 401/14
C07D 417/14
C07D 413/04
C07D 403/04
C07D 409/14
C07D 491/107
C07D 498/10
C07D 473/16
C07D 487/04
C07D 407/14
C07D 239/48
C07D 471/10
C07D 495/10
C07D 487/14
A61K 31/497
A61K 31/433
A61K 31/53
A61K 31/4439
A61K 31/427
A61K 31/52
A61K 31/5377
A61K 31/505
A61K 31/519
A61K 31/55
A61P 35/00
A61P 35/02
A61P 37/06
A61P 11/06
A61P 17/00
A61P 19/02
A61P 25/28
A61P 11/00
A61P 1/00
A61P 29/00

US Classification:

51421016, 544324, 544295, 548128, 544405, 544209, 544230, 544 71, 544212, 5462697, 544277, 548181, 544333, 544122, 544331, 544323, 544247, 540521, 544131, 544328, 514275, 51425505, 514361, 514245, 514256, 5142305, 514339, 514365, 5142632, 5142352, 514257, 51421206, 5142372

Abstract:

Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.