Guozheng Liu

US Patent:

20030003102, Jan 2, 2003

Filed:

Apr 1, 2002

Appl. No.:

10/112094

Inventors:

Donald Hnatowich - Brookline MA, US
Mary Rusckowski - Southborough MA, US
Guozheng Liu - Worcester MA, US

Assignee:

University of Massachusetts

International Classification:

A61K039/395
C12Q001/68

US Classification:

424/155100, 424/178100, 435/006000

Abstract:

The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the targeting moiety selectively binds to a primary, target-specific binding site of the target site or to a substance produced by or associated with the target site; (b) optionally, a clearing agent; and (c) a second conjugate comprising a complementary Morpholino oligomer and a diagnostic agent or therapeutic agent. The method comprises administering (a), optionally (b), and (c) to a mammal.