Gustavo R Rosania from Miami, FL, age 56

Automated Assay For Identification Of Individual Cells During Kinetic Assays
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US Patent:

6917884, Jul 12, 2005
Filed:

Dec 21, 2001
Appl. No.:

10/037285
Inventors:

Paul Sammak - Pittsburgh PA, US
Gustavo Rosania - Ann Arbor MI, US
Richard Rubin - Pittsburgh PA, US
Michel Nederlof - Pittsburgh PA, US
Oleg P. Lapets - Allison Park PA, US
Randall O. Shopoff - Pittsburgh PA, US
Murugan Kannan - Allison Park PA, US
International Classification:

G06T007/00
G06K009/78
G06K009/46
US Classification:

702 21, 382133, 345626
Abstract:

The present invention provides methods and software for tracking individual cells during a kinetic cell screening assay.

Combinatorial Fluorescent Library Based On The Styryl Scaffold
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US Patent:

7338428, Mar 4, 2008
Filed:

Jul 1, 2004
Appl. No.:

10/880614
Inventors:

Young-Tae Chang - New York NY, US
Gustavo Rosania - Ann Arbor MI, US
Assignee:

New York University - New York NY
International Classification:

C40B 40/04
US Classification:

506 15
Abstract:

A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.

Microbead-Based Test Methods For Fluorescence Imaging Systems
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US Patent:

7482167, Jan 27, 2009
Filed:

Mar 11, 2005
Appl. No.:

11/078998
Inventors:

Paul Sammak - Pittsburgh PA, US
Gustavo Rosania - Ann Arbor MI, US
Lawrence J. Zana - Gibsonia PA, US
Kim Ippolito - Pittsburgh PA, US
Jason Bush - Pittsburgh PA, US
Alex Friedman - Pittsburgh PA, US
Sarah Burroughs Tencza - Pittsburgh PA, US
Ravi Kapur - Gibsonia PA, US
Assignee:

Cellomics, Inc. - Pittsburgh PA
International Classification:

G01N 33/48
US Classification:

436164, 422 8207, 422 8208
Abstract:

The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.

Rna-Selective Probes For Live Cell Imaging Of Nuclear Structure And Function
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US Patent:

7790896, Sep 7, 2010
Filed:

Mar 1, 2007
Appl. No.:

11/680731
Inventors:

Young-Tae Chang - New York NY, US
Qian Li - New York NY, US
Gustavo Rosania - Ann Arbor MI, US
Assignee:

New York University - New York NY
International Classification:

C07D 215/38
US Classification:

546178
Abstract:

The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications.

Methods For Determining The Organization Of A Cellular Component Of Interest
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US Patent:

8050868, Nov 1, 2011
Filed:

Mar 25, 2002
Appl. No.:

10/106589
Inventors:

Gustavo Rosania - Ann Arbor MI, US
Paul Sammak - Pittsburgh PA, US
Richard Rubin - Pittsburgh PA, US
Assignee:

Cellomics, Inc. - Pittsburgh PA
International Classification:

G06K 9/00
G01N 33/48
G01N 33/50
US Classification:

702 19, 382132, 382133
Abstract:

The present invention provides automated methods and associated software for determining the organization of a component of interest in individual cells by determining the amount or distribution of the cellular component of interest as a function of position relative to a reference component in the individual cells.

Microbead-Based Test Plates And Test Methods For Fluorescence Imaging Systems
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US Patent:

20020098588, Jul 25, 2002
Filed:

Nov 30, 2001
Appl. No.:

09/997821
Inventors:

Paul Sammak - Pittsburgh PA, US
Gustavo Rosania - Ann Arbor MI, US
Lawrence Zana - Gibsonia PA, US
Kim Ippolito - Pittsburgh PA, US
Jason Bush - Pittsburgh PA, US
Alex Friedman - Pittsburgh PA, US
Sarah Tencza - Pittsburgh PA, US
Ravi Kapur - Gibsonia PA, US
International Classification:

G01N021/93
US Classification:

436/008000, 436/172000, 422/058000, 422/082080, 156/067000
Abstract:

The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.

Chemical Address Tags
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US Patent:

20070111251, May 17, 2007
Filed:

Sep 2, 2004
Appl. No.:

10/570416
Inventors:

Gustavo Rosania - Ann Arbor MI, US
Kerby Shedden - Ann Arbor MI, US
International Classification:

C40B 30/06
C40B 40/04
US Classification:

435007100, 546181000, 546347000
Abstract:

The present invention provides methods and compositions related to the fields of chemoinformatics, chemogenomics, drug discovery and development, and drug targeting. In particular, the present invention provides subcellular localization signals (e.g., chemical address tags) that influence (e.g., direct) subcellular and organelle level localization of associated compounds (e.g., drugs and small molecule therapeutics, radioactive species, dyes and imagining agents, proapoptotic agents, antibiotics, etc) in target cells and tissues. The compositions of the present invention modulate the pharmacological profiles of associated compounds by influencing the compound's accumulation, or exclusion, from subcellular loci such as mitochondria, endoplasmic reticulum, cytoplasm, vesicles, granules, nuclei and nucleoli and other subcellular organelles and compartments. The present invention also provides methods for identifying chemical address tags, predicting their targeting characteristics, and for rational designing chemical libraries comprising chemical address tags.

Compositions And Methods For Delivering Pharmaceutical Agents
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US Patent:

20160220710, Aug 4, 2016
Filed:

Jan 29, 2016
Appl. No.:

15/011047
Inventors:

- Ann Arbor MI, US
Gi S. Yoon - Ann Arbor MI, US
Kathleen Stringer - Ann Arbor MI, US
Gustavo Rosania - Ann Arbor MI, US
Chao Tian - Ann Arbor MI, US
Xueding Wang - Canton MI, US
International Classification:

A61K 49/22
A61K 31/498
A61K 9/127
Abstract:

Provided herein are microcrystalline forms of drugs. In particular, provided herein are microcrystalline drug formulations for delivery to macrophages and treatment of disease.