Gustavo R Rosania

US Patent:

6917884, Jul 12, 2005

Filed:

Dec 21, 2001

Appl. No.:

10/037285

Inventors:

Paul Sammak - Pittsburgh PA, US
Gustavo Rosania - Ann Arbor MI, US
Richard Rubin - Pittsburgh PA, US
Michel Nederlof - Pittsburgh PA, US
Oleg P. Lapets - Allison Park PA, US
Randall O. Shopoff - Pittsburgh PA, US
Murugan Kannan - Allison Park PA, US

International Classification:

G06T007/00
G06K009/78
G06K009/46

US Classification:

702 21, 382133, 345626

Abstract:

The present invention provides methods and software for tracking individual cells during a kinetic cell screening assay.

US Patent:

7338428, Mar 4, 2008

Filed:

Jul 1, 2004

Appl. No.:

10/880614

Inventors:

Young-Tae Chang - New York NY, US
Gustavo Rosania - Ann Arbor MI, US

Assignee:

New York University - New York NY

International Classification:

C40B 40/04

US Classification:

506 15

Abstract:

A combinatorial library of fluorescent compounds useful as organelle-specific probes are produced by reacting an aldehyde with a 2- or 4-methylpyridinium salt.

US Patent:

7482167, Jan 27, 2009

Filed:

Mar 11, 2005

Appl. No.:

11/078998

Inventors:

Paul Sammak - Pittsburgh PA, US
Gustavo Rosania - Ann Arbor MI, US
Lawrence J. Zana - Gibsonia PA, US
Kim Ippolito - Pittsburgh PA, US
Jason Bush - Pittsburgh PA, US
Alex Friedman - Pittsburgh PA, US
Sarah Burroughs Tencza - Pittsburgh PA, US
Ravi Kapur - Gibsonia PA, US

Assignee:

Cellomics, Inc. - Pittsburgh PA

International Classification:

G01N 33/48

US Classification:

436164, 422 8207, 422 8208

Abstract:

The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.

US Patent:

7790896, Sep 7, 2010

Filed:

Mar 1, 2007

Appl. No.:

11/680731

Inventors:

Young-Tae Chang - New York NY, US
Qian Li - New York NY, US
Gustavo Rosania - Ann Arbor MI, US

Assignee:

New York University - New York NY

International Classification:

C07D 215/38

US Classification:

546178

Abstract:

The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications.

US Patent:

8050868, Nov 1, 2011

Filed:

Mar 25, 2002

Appl. No.:

10/106589

Inventors:

Gustavo Rosania - Ann Arbor MI, US
Paul Sammak - Pittsburgh PA, US
Richard Rubin - Pittsburgh PA, US

Assignee:

Cellomics, Inc. - Pittsburgh PA

International Classification:

G06K 9/00
G01N 33/48
G01N 33/50

US Classification:

702 19, 382132, 382133

Abstract:

The present invention provides automated methods and associated software for determining the organization of a component of interest in individual cells by determining the amount or distribution of the cellular component of interest as a function of position relative to a reference component in the individual cells.

US Patent:

20020098588, Jul 25, 2002

Filed:

Nov 30, 2001

Appl. No.:

09/997821

Inventors:

Paul Sammak - Pittsburgh PA, US
Gustavo Rosania - Ann Arbor MI, US
Lawrence Zana - Gibsonia PA, US
Kim Ippolito - Pittsburgh PA, US
Jason Bush - Pittsburgh PA, US
Alex Friedman - Pittsburgh PA, US
Sarah Tencza - Pittsburgh PA, US
Ravi Kapur - Gibsonia PA, US

International Classification:

G01N021/93

US Classification:

436/008000, 436/172000, 422/058000, 422/082080, 156/067000

Abstract:

The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.

US Patent:

20070111251, May 17, 2007

Filed:

Sep 2, 2004

Appl. No.:

10/570416

Inventors:

Gustavo Rosania - Ann Arbor MI, US
Kerby Shedden - Ann Arbor MI, US

International Classification:

C40B 30/06
C40B 40/04

US Classification:

435007100, 546181000, 546347000

Abstract:

The present invention provides methods and compositions related to the fields of chemoinformatics, chemogenomics, drug discovery and development, and drug targeting. In particular, the present invention provides subcellular localization signals (e.g., chemical address tags) that influence (e.g., direct) subcellular and organelle level localization of associated compounds (e.g., drugs and small molecule therapeutics, radioactive species, dyes and imagining agents, proapoptotic agents, antibiotics, etc) in target cells and tissues. The compositions of the present invention modulate the pharmacological profiles of associated compounds by influencing the compound's accumulation, or exclusion, from subcellular loci such as mitochondria, endoplasmic reticulum, cytoplasm, vesicles, granules, nuclei and nucleoli and other subcellular organelles and compartments. The present invention also provides methods for identifying chemical address tags, predicting their targeting characteristics, and for rational designing chemical libraries comprising chemical address tags.

US Patent:

20160220710, Aug 4, 2016

Filed:

Jan 29, 2016

Appl. No.:

15/011047

Inventors:

- Ann Arbor MI, US
Gi S. Yoon - Ann Arbor MI, US
Kathleen Stringer - Ann Arbor MI, US
Gustavo Rosania - Ann Arbor MI, US
Chao Tian - Ann Arbor MI, US
Xueding Wang - Canton MI, US

International Classification:

A61K 49/22
A61K 31/498
A61K 9/127

Abstract:

Provided herein are microcrystalline forms of drugs. In particular, provided herein are microcrystalline drug formulations for delivery to macrophages and treatment of disease.