Hai Lin Lin

US Patent:

20070117217, May 24, 2007

Filed:

Jun 9, 2006

Appl. No.:

11/450888

Inventors:

Ratnesh Lal - Goleta CA, US
Daniel Cohen - Santa Barbara CA, US
Hai Lin - Goleta CA, US
Arjan Quist - Lombard IL, US
Srinivasan Ramachandran - Goleta CA, US

International Classification:

G01N 33/563

US Classification:

436513000

Abstract:

This invention provides a device and methods for the rapid detection and/or diagnosis and/or characterization of one or more allergies (e.g., causes IgE mediated allergic reaction (immediate hypersensitvity) in a mammal (e.g., a human or a non-human mammal). In certain embodiments, the device comprises a microcantilever array where different cantilevers comprising the array bear different antigens. Binding of IgE to the antigen on a cantilever causes bending of the cantilever which can be readily detected.

US Patent:

20070238184, Oct 11, 2007

Filed:

Jun 9, 2006

Appl. No.:

11/450146

Inventors:

Ratnesh Lal - Goleta CA, US
Arjan Quist - Lombard IL, US
Sungho Jin - San Diego CA, US
Hai Lin - Goleta CA, US

International Classification:

G01N 33/00
B01J 47/00
C01B 31/00

US Classification:

436086000, 422255000, 42344500B

Abstract:

The present invention relates to a novel channel structure of human amyloid beta protein (AbP) in lipid membranes and a rapid, quantitative and specific assay for screening test compounds, such as drugs, ligands (natural or synthetic), proteins, peptides and small organic molecules for their ability to bind and block the membrane AbP channels. The invention further relates to screening and identifying therapeutically relevant compounds for treating Alzheimer's disease and other disorders.

US Patent:

6365726, Apr 2, 2002

Filed:

May 22, 2000

Appl. No.:

09/578458

Inventors:

Dennis G. Ballinger - Menlo CA
John Ford - San Mateo CA
Alice Suk-Yue Ho - Union City CA
Hai Shan Lin - Castro Valley CA
Ann M. Pace - Scotts Valley CA

Assignee:

Hyseq, Inc. - Sunnyvale CA

International Classification:

C07H 2104

US Classification:

536 2352, 536 231, 536 235, 536 2431, 435 691, 435 6952, 4353201

Abstract:

The present invention provides novel nucleic acids encoding IL-1 Hy2, a novel member of the Interleukin-1 Receptor Antagonist family, the novel polypeptides encoded by these nucleic acids and uses of these and related products.

US Patent:

20220259667, Aug 18, 2022

Filed:

Jul 20, 2020

Appl. No.:

17/597760

Inventors:

- Pleasanton CA, US
Hai Lin - San Bruno CA, US
Alexander Lovejoy - Newark CA, US
Khai Luong - Oakland CA, US
Ehsan Tabari - San Francisco CA, US

International Classification:

C12Q 1/6886
G16B 20/20
G16B 40/20

Abstract:

The present invention relates generally to classification of biological samples, and more specifically to cell of original classification. In particular, some embodiments of the invention relate to diffuse large B cell lymphoma cell of origin classification using machine learning models. The machine learning models can be based on decision trees such as a random forest algorithm or a gradient boosted decision tree. Features for the models can be determined through analysis of variant data from plasma or blood samples from a plurality of subjects with the disease.