Dr. Xu graduated from the Peking Union Med Coll, Beijing, Beijing, China in 1995. He works in Winnetka, CA and specializes in Internal Medicine. Dr. Xu is affiliated with Encino Hospital Medical Center, Northridge Hospital Medical Center, Providence Tarzana Medical Center and West Hills Hospital & Medical Center.
Frances Trail - Mason MI, US Raymond Hammerschmidt - East Lansing MI, US John Linz - East Lansing MI, US Haixin Xu - East Lansing MI, US Luis Velasquez - Lansing MI, US Seanna Annis - Bangor ME, US
Assignee:
Board of Trustees of Michigan State University - East Lansing MI
International Classification:
A61K031/445 C07D211/60
US Classification:
514315000, 546245000
Abstract:
The present invention provides an alkaloid compound that is an inhibitor of mycotoxin biosynthesis. The alkaloid is an alkenyl piperidine amide wherein the alkenyl is a C18 alkenyl with one or more double bonds. The alkaloid inhibits transcription of the fungus genes nor-1, tri5, and ipnA. The present invention further provides a method for identifying compounds, which inhibit biosynthesis of aflatoxin in spp. and deoxynivalenol in spp. without inhibiting growth of the fungus in vitro.
Alkaloid That Inhibits Biosynthesis Of Mycotoxins And Method For Screening For Mycotoxin Inhibitors
Frances Trail - Mason MI, US Raymond Hammerschmidt - East Lansing MI, US John Linz - East Lansing MI, US Haixin Xu - East Lansing MI, US Luis Velasquez - Lansing MI, US Seanna Annis - Bangor ME, US
Assignee:
Board of Trustees of Michigan State University - East Lansing MI
International Classification:
C12Q001/18 A61K031/445
US Classification:
514317000, 435032000
Abstract:
The present invention provides an alkaloid compound that is an inhibitor of mycotoxin biosynthesis. The alkaloid is an alkenyl piperidine amide wherein the alkenyl is a C18 alkenyl with one or more double bonds. The alkaloid inhibits transcription of the fungus genes nor-1, tri5, and ipnA. The present invention further provides a method for identifying compounds, which inhibit biosynthesis of aflatoxin in spp. and deoxynivalenol in spp. without inhibiting growth of the fungus in vitro.