Han Yong Cao from 13114 Bustleton Ave, Philadelphia, PA 19116, age 65, Phone: (215)4641482

Name / Title

Company / Classification

Phones & Addresses

Han Cao
Founder And Chief Scientific Officer

Bionanomatrix Inc
Nonclassifiable Establishments · Services-Misc

3700 Market St, Philadelphia, PA 19104
3701 Market St FL 4, Philadelphia, PA 19104
(267)4992014

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Methods And Devices For Single-Molecule Whole Genome Analysis
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US Patent:

8628919, Jan 14, 2014
Filed:

Jun 30, 2009
Appl. No.:

13/001697
Inventors:

Ming Xiao - Huntingdon Valley PA, US
Parikshit A. Deshpande - Princeton NJ, US
Han Cao - Philadelphia PA, US
Michael Austin - Philadelphia PA, US
Kandaswamy Vijayan - San Diego CA, US
Alexey Y. Sharonov - Hamden CT, US
Michael Boyce-Jacino - Titusville NJ, US
Assignee:

Bionano Genomics, Inc. - Philadelphia PA
International Classification:

C12Q 1/68
C12M 1/34
C12M 3/00
C07H 21/02
US Classification:

435 61, 435 611, 4352872, 536 231, 977704
Abstract:

Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e. g. , determining structural variations and copy number variations between individuals.

Methods Of Macromolecular Analysis Using Nanochannel Arrays
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US Patent:

20080242556, Oct 2, 2008
Filed:

Mar 28, 2008
Appl. No.:

12/057987
Inventors:

Han Cao - Philadelphia PA, US
Parikshit A. Deshpande - Philadelphia PA, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US
Assignee:

BIONANOMATRIX, LLC - Philadelphia PA
International Classification:

C40B 30/04
C40B 60/12
C40B 30/10
C40B 30/06
US Classification:

506 9, 506 39, 506 12, 506 10
Abstract:

Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.

Nanonozzle Device Arrays: Their Preparation And Use For Macromolecular Analysis
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US Patent:

20090305273, Dec 10, 2009
Filed:

Jul 19, 2007
Appl. No.:

12/374141
Inventors:

Han Cao - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Michael D. Austin - Philadelphia PA, US
Michael Boyce-Jacino - Titusville NJ, US
Assignee:

BIONANOMATRIX, INC. - PHILADELPHIA PA
International Classification:

C12Q 1/68
C12M 1/34
US Classification:

435 6, 4352872
Abstract:

Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices.

Nanochannel Arrays And Their Preparation And Use For High Throughput Macromolecular Analysis
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US Patent:

20100029508, Feb 4, 2010
Filed:

Oct 30, 2008
Appl. No.:

12/261406
Inventors:

Robert H. Austin - Princeton NJ, US
Zhaoning Yu - Princeton NJ, US
Jonas O. Tegenfeldt - Princeton NJ, US
Stephen Y. Chou - Princeton NJ, US
Han Cao - Philadelphia PA, US
Assignee:

THE TRUSTEES OF PRINCETON UNIVERSITY - Princeton NJ
International Classification:

C40B 40/06
C40B 40/00
C40B 50/14
C40B 60/12
C40B 30/00
US Classification:

506 16, 506 13, 506 30, 506 39, 506 7
Abstract:

Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.

Integrated Analysis Devices And Related Fabrication Methods And Analysis Techniques
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US Patent:

20110296903, Dec 8, 2011
Filed:

Jun 5, 2009
Appl. No.:

12/996410
Inventors:

Han Cao - Philadelphia PA, US
Michael D. Austin - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Mark Kunkel - Lawrenceville NJ, US
Alexey Y. Sharonov - Hamden CT, US
Michael Kochersperger - Princeton NJ, US
Assignee:

Bionanomatrix, Inc. - Philadelphai PA
International Classification:

G01N 1/16
B32B 37/16
B23P 17/00
G01N 21/64
B32B 37/02
B82Y 15/00
US Classification:

73 6456, 2504591, 156292, 29423, 977902, 977781
Abstract:

Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.

Polynucleotide Mapping And Sequencing
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US Patent:

20110306504, Dec 15, 2011
Filed:

Nov 18, 2009
Appl. No.:

13/129634
Inventors:

Ming Xiao - Huntington Valley PA, US
Han Cao - Philadelphia PA, US
Parikshit A. Deshpande - Princeton NJ, US
Michael Boyce-Jacino - Titusville NJ, US
Assignee:

Bionanomatrix, Inc. - Philadelphia PA
International Classification:

C40B 20/08
C40B 40/06
C12Q 1/68
G01N 21/64
US Classification:

506 6, 436501, 506 16, 435 611
Abstract:

The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.

Methods And Devices For Single-Molecule Whole Genome Analysis
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US Patent:

20130240357, Sep 19, 2013
Filed:

Feb 12, 2013
Appl. No.:

13/765353
Inventors:

Ming Xiao - Huntingdon Valley PA, US
Han Cao - San Diego CA, US
Assignee:

BioNano Genomics, Inc. - San Diego CA
International Classification:

G06F 19/18
US Classification:

204451
Abstract:

Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g. determining structural variations and copy number variations between individuals.

Polynucleotide Mapping And Sequencing
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US Patent:

20160097092, Apr 7, 2016
Filed:

Oct 7, 2015
Appl. No.:

14/877818
Inventors:

- San Diego CA, US
HAN CAO - Philadelphia PA, US
PARIKSHIT A. DESHPANDE - Princeton NJ, US
MICHAEL BOYCE-JACINO - Titusville NJ, US
International Classification:

C12Q 1/68
Abstract:

The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.