John N. Feder - Belle Mead NJ, US Liana Lee - North Brunswick NJ, US Jian Chen - Princeton NJ, US Nathan O. Siemers - Pennington NJ, US Han Chang - Princeton Junction NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12N 5/00
US Classification:
435325, 4353201, 4352523, 435 6, 536 235
Abstract:
The present invention provides novel polynucleotides encoding HGRA4 polypeptides, fragments and homologues thereof. The present invention also provides novel polynucleotides encoding a HGRA4 splice variant, HGRA4sv. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGRA4 and HGRA4sv polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Polynucleotide Encoding A Trp Channel Family Member, Trp-Plik2
Ning Lee - Belle Mead NJ, US Jian Chen - Princeton NJ, US John N. Feder - Belle Mead NJ, US Shujian Wu - Langhorne PA, US Han Chang - Princeton Junction NJ, US Liana M. Le - San Francisco CA, US Michael A. Blanar - Malvern PA, US David Bol - Gaithersburg MD, US
The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Polypeptide For A Trp Channel Family Member, Trp-Plik2, And Splice Variants
Ning Lee - Belle Mead NJ, US Jian Chen - Princeton NJ, US Shujian Wu - Langhorne PA, US Han Chang - Princeton Junction NJ, US Michael A. Blanar - Malvern PA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 14/47 C12N 15/07 C12N 15/64 C12P 21/02
US Classification:
530350, 435 691, 4353201, 435325, 435471
Abstract:
The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel TRP-PLIK2, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Polynucleotide Encoding A Novel Human Potassium Channel Beta-Subunit, K+Mbeta1
John Feder - Belle Mead NJ, US Liana Lee - North Brunswick NJ, US Jian Chen - Princeton NJ, US Donald Jackson - Lawrenceville NJ, US Chandra Ramanathan - Wallingford CT, US Nathan Siemers - Pennington NJ, US Han Chang - Princeton Junction NJ, US
The present invention provides novel polynucleotides encoding K+Mbeta1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+Mbeta1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Polynucleotide Encoding A Novel Human Potassium Channel Beta-Subunit, K+Betam6, Expressed Highly In The Small Intestine
John Feder - Belle Mead NJ, US Liana Lee - North Brunswick NJ, US Jian Chen - Princeton NJ, US Donald Jackson - Lawrenceville NJ, US Chandra Ramanathan - Wallingford CT, US Nathan Siemers - Pennington NJ, US Han Chang - Princeton Junction NJ, US
The present invention provides novel polynucleotides encoding K+betaM6 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+betaM6 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Polynucleotide Encoding Two Novel Human Potassium Channel Beta-Subunits, K+Betam4 And K+Betam5
John Feder - Belle Mead NJ, US Liana Lee - North Brunswick NJ, US Jian Chen - Princeton NJ, US Donald Jackson - Lawrenceville NJ, US Chandra Ramanathan - Wallingford CT, US Nathan Siemers - Pennington NJ, US Han Chang - Princeton Junction NJ, US Pamela Carroll - Princeton NJ, US
The present invention provides novel polynucleotides encoding K+betaM4 or K+betaM5 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+betaM4 or K+betaM5 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Polynucleotide Encoding A Novel Human Potassium Channel Alpha-Subunit, K+Alpham1, And Variants Thereof
John Feder - Belle Mead NJ, US Liana Lee - North Brunswick NJ, US Jian Chen - Princeton NJ, US Donald Jackson - Lawrenceville NJ, US Chandra Ramanathan - Wallingford CT, US Nathan Siemers - Pennington NJ, US Han Chang - Princeton Junction NJ, US
International Classification:
C07H021/02 C07H021/04 C12N001/20
US Classification:
435/252300, 536/023100
Abstract:
The present invention provides novel polynucleotides encoding K+alphaM1 polypeptides, fragments and homologues thereof. The invention also provides novel polynucleotides encoding the K+alphaM1 variant polypeptides, K+alphaM1.v1 and K+alphaM1.v2, in addition to fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel K+alphaM1, K+alphaM1.v1, and K+alphaM1.v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Polynucleotide Encoding A Novel Potassium Channel With Homology To The Ether-A-Go-Go Family, Heag2
John Feder - Belle Mead NJ, US Liana Lee - North Brunswick NJ, US Jian Chen - Princeton NJ, US Donald Jackson - Lawrenceville NJ, US Chandra Ramanathan - Wallingford CT, US Nathan Siemers - Pennington NJ, US Han Chang - Princeton Junction NJ, US Franck Duclos - Washington Crossing PA, US Stanley Krystek - Ringoes NJ, US
The present invention provides novel polynucleotides encoding HEAG2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HEAG2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Dr. Chang graduated from the Seoul Natl Univ, Coll of Med, Chongno Ku, Seoul, So Korea in 1966. He works in North Tonawanda, NY and specializes in Internal Medicine. Dr. Chang is affiliated with Degraff Memorial Hospital.