Han Hsin Chang

US Patent:

7279567, Oct 9, 2007

Filed:

Nov 22, 2004

Appl. No.:

10/994824

Inventors:

Glen Eugene Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Robert James Peach - San Diego CA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/04
C12N 5/10
C12N 1/21
C12N 15/00
C12N 15/11

US Classification:

536 235, 536 231, 536 2353, 435 691, 4353201, 4352523, 435455

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

7358354, Apr 15, 2008

Filed:

Feb 16, 2006

Appl. No.:

11/355735

Inventors:

Glen Eugene Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Robert James Peach - San Diego CA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/04
C12N 15/00
C12N 1/21
C12N 5/16
C12P 21/02

US Classification:

536 235, 536 231, 536 234, 536 2353, 4353201, 4352523, 435455, 435 691

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

7368554, May 6, 2008

Filed:

Feb 2, 2006

Appl. No.:

11/346468

Inventors:

Glen E Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Robert James Peach - San Diego CA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/04
C12N 15/00
C12N 1/21
C12N 5/16
C12N 21/02

US Classification:

536 235, 536 231, 536 234, 536 2353, 4353201, 4352523, 435455, 435 691

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

7723479, May 25, 2010

Filed:

Sep 6, 2007

Appl. No.:

11/900026

Inventors:

Glen Eugene Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Joshua N. Finger - Spring City PA, US
Guchen Yang - Princeton NJ, US
Robert James Peach - San Diego CA, US
Henry Shen - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/705

US Classification:

530350

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

7807786, Oct 5, 2010

Filed:

Feb 7, 2008

Appl. No.:

12/069064

Inventors:

Glen Eugene Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Robert James Peach - San Diego CA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 14/00

US Classification:

530350

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

8080636, Dec 20, 2011

Filed:

Feb 5, 2010

Appl. No.:

12/701119

Inventors:

Glen Eugene Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Robert James Peach - San Diego CA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 16/00

US Classification:

5303871

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

8354513, Jan 15, 2013

Filed:

May 20, 2010

Appl. No.:

12/783968

Inventors:

Glen Eugene Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Robert James Peach - San Diego CA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/04

US Classification:

536 231

Abstract:

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

US Patent:

20030036631, Feb 20, 2003

Filed:

Jul 20, 2001

Appl. No.:

09/910600

Inventors:

Malinda Longphre - Oakland CA, US
Han Chang - Princeton Junction NJ, US
Gena Whitney - Lawrenceville NJ, US

International Classification:

C07K014/705

US Classification:

530/350000, 530/388100

Abstract:

The present invention provides proteins, peptide fragments, nucleic acid molecules and fragments thereof, complementary sequences, allelic forms, homologues, antibodies and variants of SIGLEC-BMS sequences, which are new members of the Sialoadhesin subgroup having protein homology to CD33, and methods of using these molecules.