Haoyun C An

US Patent:

6414135, Jul 2, 2002

Filed:

Jul 7, 1999

Appl. No.:

09/349035

Inventors:

Phillip Dan Cook - Fallbrook CA
Haoyun An - Carlsbad CA
Tingmin Wang - San Marcos CA
Muthiah Manoharan - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2100

US Classification:

536 253

Abstract:

The present invention is directed to nucleoside monomers wherein the 3â-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylenephosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.

US Patent:

6639061, Oct 28, 2003

Filed:

Jul 7, 1999

Appl. No.:

09/349033

Inventors:

Phillip Dan Cook - Fallbrook CA
Muthiah Manoharan - Carlsbad CA
Martin Maier - Carlsbad CA
Haoyun An - Carlsbad CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2102

US Classification:

536 231, 536 221, 536 2331, 536 253, 536 261, 536 271, 435 6, 435 911

Abstract:

The present invention is directed to nucleoside monomers wherein the 3â-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.

US Patent:

6800444, Oct 5, 2004

Filed:

Jun 30, 1998

Appl. No.:

09/107688

Inventors:

Phillip Dan Cook - Escondido CA
Haoyun An - Encinitas CA

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

G01N 3353

US Classification:

435 71, 546298

Abstract:

Compositions comprising novel chemical libraries are prepared. The compositions of the present invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.

US Patent:

6833361, Dec 21, 2004

Filed:

Apr 30, 2002

Appl. No.:

10/136932

Inventors:

Zhi Hong - Aliso Viejo CA
Haoyun An - Carlsbad CA

Assignee:

Ribapharm, Inc. - Costa Mesa CA

International Classification:

A61K 3170

US Classification:

514 45, 514 46, 514 47, 514 48, 514 49, 514 50, 514 51, 536 267, 536 268

Abstract:

Conformationally restricted 2â, 4â-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2â and C4â of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients, and especially for use in treatment of HCV.

US Patent:

6906190, Jun 14, 2005

Filed:

Dec 27, 2002

Appl. No.:

10/330369

Inventors:

Nanhua Yao - Irvine CA, US
Haoyun An - Carlsbad CA, US
Todd Appleby - Laguna Niguel CA, US
Shahul Nilar - Irvine CA, US
Yili Ding - Fountain Valley CA, US
Zhi Hong - Aliso Viejo CA, US

Assignee:

Ribapharm Inc. - Costa Mesa CA

International Classification:

C07D473/16
C07D473/18
C07D473/30
C07D473/34
A61P031/14

US Classification:

544276, 544265, 544277, 536 276, 536 2761

Abstract:

A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.

US Patent:

6974865, Dec 13, 2005

Filed:

Dec 18, 2002

Appl. No.:

10/322242

Inventors:

Phillip Dan Cook - Fallbrook CA, US
Muthiah Manoharan - Carlsbad CA, US
Martin Maier - Carlsbad CA, US
Haoyun An - Carlsbad CA, US

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H021/02
C07H021/04

US Classification:

536 231, 536 221, 536 245, 536 253, 536 2531, 536 2534, 536 256, 536 261, 435 87, 435 90, 435 911, 435 912, 435 915

Abstract:

The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, methods of preparing monomers and oligomers according to the present invention are provided.

US Patent:

6989451, Jan 24, 2006

Filed:

Jun 4, 2003

Appl. No.:

10/455149

Inventors:

Weijian Zhang - Irvine CA, US
William Ricketts - Irvine CA, US
Haoyun An - Carlsbad CA, US
Zhi Hong - Aliso Viejo CA, US

Assignee:

Valeant Research & Development - Costa Mesa CA

International Classification:

C07D 275/03
A61K 31/425

US Classification:

548206, 548213, 548214, 514372

Abstract:

Substituted isothiazole compounds and compositions are provided, wherein particularly preferred compositions and methods are directed towards inhibition of various protein kinases (especially MEK and/or ERK). Consequently, particularly preferred methods include treatment of diseases associated with abnormality in MEK and/or ERK function.

US Patent:

7189724, Mar 13, 2007

Filed:

Apr 15, 2004

Appl. No.:

10/826439

Inventors:

Haoyun An - Carlsbad CA, US
Frank Rong - Irvine CA, US
Jim Wu - Aliso Viejo CA, US
Clayton Harris - Irvine CA, US
Suetying Chow - Diamond Bar CA, US

Assignee:

Valeant Research and Development - Costa Mesa CA

International Classification:

A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
C07D 241/36

US Classification:

514249, 514250, 544344, 544347, 544353

Abstract:

The invention provides substituted quinoxalines having the general formulas.