Harold B Leeper

US Patent:

39385159, Feb 17, 1976

Filed:

Oct 19, 1973

Appl. No.:

5/408233

Inventors:

Harold M. Leeper - Mountain View CA
Alan S. Michaels - Atherton CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61F 546
A61F 1320
A61M 3100

US Classification:

128260

Abstract:

A polymeric wall adapted to release drug at a controlled rate for a prolonged period of time from a reservoir comprising a drug and a carrier which is permeable to the drug and saturated therewith during said prolonged period of time, to a body environment or a drug receptor site, the wall comprising a mixture of a polymer which is biologically compatible with said environment or site and maintains its integrity while in contact therewith, has a glass transition temperature between ambient temperature and 150. degree. C, a crystallinity of 5% to 95%, or is rubbery, and is permeable to the drug but at a rate less than that of the carrier and as a minor constituent a polymeric additive such as a polyester prepared from a glycol and a dibasic acid, polyethylene glycol, chlorinated polyethylene or copolymers of ethylene and vinyl esters or vinyl esters or vinyl halides, the amount of additive being sufficient to make the permeability of the wall to the drug substantially different than the permeability of the polymer to the drug but still less than the permeability of the carrier to the drug.

US Patent:

46018808, Jul 22, 1986

Filed:

Apr 11, 1985

Appl. No.:

6/722247

Inventors:

Patrick S. L. Wong - Kowloon, HK
Jimmy B. Langston - San Jose CA
Harold M. Leeper - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61L 200

US Classification:

422 28

Abstract:

A patient-care system is disclosed comprising a container housing a device that delivers an agent for controlling the presence of pathogens. Also, the device and a method are disclosed using the device for preventing pathogenic infections.

US Patent:

44642580, Aug 7, 1984

Filed:

Jan 3, 1983

Appl. No.:

6/455391

Inventors:

Patrick S. Wong - Kowloon, HK
Jimmy B. Langston - San Jose CA
Harold M. Leeper - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

C02B 306

US Classification:

210205

Abstract:

A patient-care system is disclosed comprising a container housing a device that delivers an agent for controlling the presence of pathogens. Also, the device and a method are disclosed using the device for preventing pathogenic infections.

US Patent:

44458894, May 1, 1984

Filed:

Jul 12, 1982

Appl. No.:

6/397507

Inventors:

Patrick S. Wong - Kowloon, HK
Jimmy B. Langston - San Jose CA
Harold M. Leeper - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61M 3100

US Classification:

604 49

Abstract:

A method for preventing an infection in a patient introduced through a indwelling catheter, the method comprising, connecting the patient to the catheter, connecting the catheter to a fluid receiving container, admitting into the container a biocidal dispensing device, and releasing a biocide into fluid in the container for inhibiting the growth of infectious bacteria in the container and concomitantly their introduction into the catheter and the patient.

US Patent:

41934032, Mar 18, 1980

Filed:

Jun 9, 1977

Appl. No.:

5/804962

Inventors:

Jimmy B. Langston - San Jose CA
Harold Leeper - Mountain View CA
Patrick S. Wong - Palo Alto CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61F 544

US Classification:

128275

Abstract:

A patient-care apparatus housing a device for controlling the presence of pathogens is disclosed. The apparatus comprises a container with an inlet port and a device in the apparatus for controlling the presence of pathogens.

US Patent:

41443098, Mar 13, 1979

Filed:

Jun 9, 1977

Appl. No.:

5/804961

Inventors:

Jimmy B. Langston - San Jose CA
Harold Leeper - Mountain View CA
Patrick S. Wong - Palo Alto CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61L 904

US Classification:

422305

Abstract:

A device for dispensing a microcide which consists of a first polymeric material housing a second polymeric material which second material depolymerizes when the device is in the environment of use to form an active microcide. The microcide controls the presence of micro-organisms in the environment over a prolonged period of time.

US Patent:

45683433, Feb 4, 1986

Filed:

Oct 9, 1984

Appl. No.:

6/659121

Inventors:

Harold M. Leeper - Mountain View CA
Diane Nedberge - Los Altos CA
Lina T. Taskovich - Palo Alto CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61K 900

US Classification:

604896

Abstract:

A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with polyethylene glycol monolaurate. Preferred embodiments of transdermal therapeutic systems for delivering drug and polyethylene glycol monolaurate employ matrix containing drug at a concentration above saturation.

US Patent:

42012074, May 6, 1980

Filed:

Nov 26, 1976

Appl. No.:

5/745132

Inventors:

Richard G. Buckles - Redwood City CA
Harold M. Leeper - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61M 500
B65D 3518
C08C 1900
C08C 1904

US Classification:

128214F

Abstract:

An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients, that dispense liquid under pressure from an expansible, elastomer bladder is disclosed. The improvement is that the bladder is made from synthetic vulcanized polyisoprene, especially polyisoprene that has 90% to 98% cis linkages and has been vulcanized with an organic peroxide, such as dicumyl peroxide, at a concentration of 5. 5. times. 10. sup. -3 to 7. 5. times. 10. sup. -3 moles of peroxide per 100 grams of polyisoprene.