Harry L Gray

US Patent:

6780856, Aug 24, 2004

Filed:

Apr 6, 2001

Appl. No.:

09/828499

Inventors:

Thomas J. Meade - Altadena CA
Ofer Blum - Ann Arbor MI
Harry B. Gray - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A61K 3133

US Classification:

514183, 514185, 514501, 544 88, 5483001

Abstract:

The invention relates to methods of stabilizing in an aqueous medium cobalt (III) Schiff base complexes and stabilized cobalt (III) Schiff base compounds therefrom.

US Patent:

7105310, Sep 12, 2006

Filed:

Jul 19, 2000

Appl. No.:

10/031532

Inventors:

Harry B. Gray - Pasadena CA, US
Brian R. Crane - Ithaca NY, US
Jay R. Winkler - Pasadena CA, US
Ivan Julian Dmochowski - Philadelphia PA, US
Jonathan J. Wilker - LaFayette IN, US
Alexander Robert Dunn - Colorado Springs CO, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01N 33/573

US Classification:

435 74, 435 4, 435 71, 435 72, 435 77, 435 792, 435 793, 435183, 435968, 436139, 436164, 436172, 436815

Abstract:

Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included.

US Patent:

20070112180, May 17, 2007

Filed:

Aug 29, 2006

Appl. No.:

11/512765

Inventors:

Harry Gray - Pasadena CA, US
Brian Crane - Ithaca NY, US
Jay Winkler - Pasadena CA, US
Ivan Dmochowski - Los Angeles CA, US
Jonathan Wilker - West Lafayette IN, US
Alexander Dunn - Colorado Springs CO, US

International Classification:

C07K 16/00

US Classification:

530391700

Abstract:

Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included.

US Patent:

20080032409, Feb 7, 2008

Filed:

Aug 7, 2007

Appl. No.:

11/834861

Inventors:

Jay R. Winkler - Pasadena CA, US
Jennifer C. Lee - Bethesda MD, US
Seth B. Harkins - Bethesda MD, US
Harry B. Gray - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01N 33/68
C07C 227/00
C07C 229/28
C07C 229/52
C07C 233/64
C07C 381/00

US Classification:

436 86, 560 18, 560 19, 560 49, 562426, 562433, 564155

Abstract:

The invention describes fluorescent biomolecule labeling reagents (I-SHark and phI-SHark) and their model compounds. Further described are methods of preparing and using the same.

US Patent:

20100305335, Dec 2, 2010

Filed:

May 24, 2010

Appl. No.:

12/800871

Inventors:

Joshua H. Palmer - Pasadena CA, US
Zeev Gross - Petach Tikva, IL
Harry B. Gray - Pasadena CA, US

International Classification:

C07F 15/00

US Classification:

548402

Abstract:

Metallocorrole complexes of third row transition metals may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications.

US Patent:

20120313073, Dec 13, 2012

Filed:

Jun 7, 2012

Appl. No.:

13/491253

Inventors:

James R. McKone - Pasadena CA, US
Harry B. Gray - Pasadena CA, US
Nathan S. Lewis - La Canada CA, US
Bruce Brunschwig - Pasadena CA, US
Emily L. Warren - Pasadena CA, US
Shannon W. Boettcher - Eugene OR, US
Matthew J. Bierman - Bay City MI, US

Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - PASADENA CA

International Classification:

H01L 31/0224

US Classification:

257 10, 438 88, 257E31124

Abstract:

A photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconductive material having a photocatalyst such as nickel or nickel-molybdenum coated on the material.

US Patent:

20130178360, Jul 11, 2013

Filed:

Jan 4, 2013

Appl. No.:

13/734088

Inventors:

California Institute of Technology - Pasadena CA, US
James R. McKone - Pasadena CA, US
Harry B. Gray - Pasadena CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

H01M 4/90
H01M 4/88

US Classification:

502315, 502300

Abstract:

The disclosure provides methods and compositions comprising metal alloy powders. The disclosure also provides a photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconductive material having a photocatalyst such as nickel or nickel-molybdenum coated on the material.

US Patent:

41275063, Nov 28, 1978

Filed:

Jan 31, 1977

Appl. No.:

5/764402

Inventors:

Harry B. Gray - Pasadena CA
Alan Rembaum - Altadena CA
Amitava Gupta - Los Angeles CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

B01J 3120
B01J 3124

US Classification:

252431N

Abstract:

Novel polymer supported catalysts are prepared by photo-irradiation of low valent transition metal compounds such as Co. sub. 2 (CO). sub. 8, Rh. sub. 4 (CO). sub. 12 or Ru. sub. 3 (CO). sub. 12 in the presence of solid polymers containing amine ligands such as polyvinyl pyridine. Hydroformylation of olefins to aldehydes at ambient conditions has been demonstrated.