A novel transcriptional regulatory element which was isolated from the MnSOD gene and which exhibits promoter-enhancer activity is disclosed. The promoter-enhancer activity of the element is further modulated by inflammatory mediators to regulate transcription. Methods of using the promoter-enhancer element to regulate gene expression, and therapeutic uses involving the promoter-enhancer element are also described.
Novel Manganese Superoxide Dismutase Regulatory Elements And Uses Therefore
A novel transcriptional regulatory element which was isolated from the MnSOD gene and which exhibits promoter-enhancer activity is disclosed. The promoter-enhancer activity of the element is further modulated by inflammatory mediators to regulate transcription. Methods of using the promoter-enhancer element to regulate gene expression, and therapeutic uses involving the promoter-enhancer element are also described.
Harry S. Nick - Gainesville FL, US Kimberly J. Aiken - Alachua FL, US Sarah J. Barilovits - Charlotte NC, US Justin S. Bickford - Gainesville FL, US Dawn E. Beachy - Gainesville FL, US
Assignee:
University of Florida Research Foundation,Inc. - Gainesville FL
International Classification:
A61K 31/7004 G01N 33/50
US Classification:
424432, 536 111, 514 23, 435 29
Abstract:
Disclosed herein are compositions and methods for controlling fertility of a female subject. Particularly exemplified are compositions comprising sugar derivatives, such as 2-deoxyglucose, D-mannoheptulose; and/or 5-thio-D-glucose. Also disclosed herein are methods of preserving ova supply in a female subject that involves administering glucose derivatives. The composition typically includes a glucose derivative that affects Foxo3a expression.
Material And Methods For Inhibiting Bacterial Cell Wall Biosynthesis
Charles M. Allen - Gainesville FL Harry S. Nick - Gainesville FL
Assignee:
University of Florida - Gainesville FL
International Classification:
A61K 31075
US Classification:
514715
Abstract:
The subject invention pertains to materials and methods for inhibiting bacterial growth. Specifically provided are compounds which control bacteria by interfering with cell wall synthesis.
Harry S. Nick - Gainesville FL David N. Silverman - Gainesville FL
Assignee:
University of Florida - Gainesville FL
International Classification:
C12N 902 C12N 1553
US Classification:
435189
Abstract:
Human manganese superoxide dismutase (hMn SOD) having catalytic activity which differs from natural hMn SOD is disclosed. The hMn SOD of the invention exhibits reduced or no product inhibition compared to natural hMn SOD, while preferably maintaining equal or improved catalytic activity. The hMn SOD of the invention can be used as an antioxidant to prevent or treat cytotoxicity resulting from oxidation.
Harry S. Nick - Gainesville FL David N. Silverman - Gainesville FL
Assignee:
University of Florida - FL
International Classification:
C12N 902
US Classification:
435189
Abstract:
Human manganese superoxide dismutase (hMn SOD) having catalytic activity which differs from natural hMn SOD is disclosed. The hMn SOD of the invention exhibits reduced or no product inhibition compared to natural hMn SOD, while preferably maintaining equal or improved catalytic activity. The hMn SOD of the invention can be used as an antioxidant to prevent or treat cytotoxicity resulting from oxidation.
Materials And Methods For Inhibiting Bacterial Cell Wall Biosynthesis
Charles M. Allen - Gainesville FL Harry S. Nick - Gainesville FL
Assignee:
University of Florida - Gainesville FL
International Classification:
A61K 31075
US Classification:
514715
Abstract:
The subject invention pertains to materials and methods for inhibiting bacterial growth. Specifically provided are compounds which control bacteria by interfering with cell wall synthesis.
University of Florida Jul 1985 - Dec 9, 2016
Professor at University of Florida
Biogen Jul 1984 - Jul 1985
Postdoctoral Research Fellow
Harvard University Jul 1982 - Jul 1985
Postdoctoral Research Fellow
Education:
University of Pennsylvania 1977 - 1982
Doctorates, Doctor of Philosophy, Biochemistry, Philosophy
Hiram College 1973 - 1977
Bachelors, Bachelor of Arts, Bachelor of Science, Biology, Chemistry, Political Science
Skills:
Molecular Biology Biochemistry Science Research Cell Culture Cell Biology Life Sciences Pcr Genetics Immunohistochemistry Laboratory Skills Immunofluorescence Real Time Polymerase Chain Reaction Dna Extraction Animal Models Fluorescence Microscopy
Interests:
Kids Collecting Cooking Exercise Investing Outdoors Sweepstakes Electronics Home Improvement Reading Crafts Gourmet Cooking Sports Automobiles Woodwork Fishing Home Decoration