Harry S Nick

US Patent:

6800458, Oct 5, 2004

Filed:

Aug 28, 2001

Appl. No.:

09/856766

Inventors:

Harry S. Nick - Gainesville FL
Richard Rogers - Gainesville FL
John F. Valentine - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

C12N 1500

US Classification:

435 692, 536 231, 536 232, 536 241, 435 691, 4353201, 435325, 435455

Abstract:

A novel transcriptional regulatory element which was isolated from the MnSOD gene and which exhibits promoter-enhancer activity is disclosed. The promoter-enhancer activity of the element is further modulated by inflammatory mediators to regulate transcription. Methods of using the promoter-enhancer element to regulate gene expression, and therapeutic uses involving the promoter-enhancer element are also described.

US Patent:

20050164237, Jul 28, 2005

Filed:

Sep 27, 2004

Appl. No.:

10/951463

Inventors:

Harry Nick - Gainesville FL, US
Richard Rogers - Gainesville FL, US
John Valentine - Gainesville FL, US

International Classification:

C12Q001/68
C07H021/04
C12N009/02

US Classification:

435006000, 435069100, 435189000, 435320100, 435325000, 536023200

Abstract:

A novel transcriptional regulatory element which was isolated from the MnSOD gene and which exhibits promoter-enhancer activity is disclosed. The promoter-enhancer activity of the element is further modulated by inflammatory mediators to regulate transcription. Methods of using the promoter-enhancer element to regulate gene expression, and therapeutic uses involving the promoter-enhancer element are also described.

US Patent:

20130315974, Nov 28, 2013

Filed:

Oct 28, 2011

Appl. No.:

13/882263

Inventors:

Harry S. Nick - Gainesville FL, US
Kimberly J. Aiken - Alachua FL, US
Sarah J. Barilovits - Charlotte NC, US
Justin S. Bickford - Gainesville FL, US
Dawn E. Beachy - Gainesville FL, US

Assignee:

University of Florida Research Foundation,Inc. - Gainesville FL

International Classification:

A61K 31/7004
G01N 33/50

US Classification:

424432, 536 111, 514 23, 435 29

Abstract:

Disclosed herein are compositions and methods for controlling fertility of a female subject. Particularly exemplified are compositions comprising sugar derivatives, such as 2-deoxyglucose, D-mannoheptulose; and/or 5-thio-D-glucose. Also disclosed herein are methods of preserving ova supply in a female subject that involves administering glucose derivatives. The composition typically includes a glucose derivative that affects Foxo3a expression.

US Patent:

57805164, Jul 14, 1998

Filed:

Mar 28, 1997

Appl. No.:

8/827521

Inventors:

Charles M. Allen - Gainesville FL
Harry S. Nick - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

A61K 31075

US Classification:

514715

Abstract:

The subject invention pertains to materials and methods for inhibiting bacterial growth. Specifically provided are compounds which control bacteria by interfering with cell wall synthesis.

US Patent:

59856335, Nov 16, 1999

Filed:

Sep 10, 1997

Appl. No.:

8/927230

Inventors:

Harry S. Nick - Gainesville FL
David N. Silverman - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

C12N 902
C12N 1553

US Classification:

435189

Abstract:

Human manganese superoxide dismutase (hMn SOD) having catalytic activity which differs from natural hMn SOD is disclosed. The hMn SOD of the invention exhibits reduced or no product inhibition compared to natural hMn SOD, while preferably maintaining equal or improved catalytic activity. The hMn SOD of the invention can be used as an antioxidant to prevent or treat cytotoxicity resulting from oxidation.

US Patent:

6107070, Aug 22, 2000

Filed:

Sep 10, 1998

Appl. No.:

9/151052

Inventors:

Harry S. Nick - Gainesville FL
David N. Silverman - Gainesville FL

Assignee:

University of Florida - FL

International Classification:

C12N 902

US Classification:

435189

Abstract:

Human manganese superoxide dismutase (hMn SOD) having catalytic activity which differs from natural hMn SOD is disclosed. The hMn SOD of the invention exhibits reduced or no product inhibition compared to natural hMn SOD, while preferably maintaining equal or improved catalytic activity. The hMn SOD of the invention can be used as an antioxidant to prevent or treat cytotoxicity resulting from oxidation.

US Patent:

59816040, Nov 9, 1999

Filed:

Jul 14, 1998

Appl. No.:

9/115281

Inventors:

Charles M. Allen - Gainesville FL
Harry S. Nick - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

A61K 31075

US Classification:

514715

Abstract:

The subject invention pertains to materials and methods for inhibiting bacterial growth. Specifically provided are compounds which control bacteria by interfering with cell wall synthesis.