Ruihuan Chen - Foster City CA, US Heidi S. Phillips - Palo Alto CA, US P. Mickey Williams - Half Moon Bay CA, US Thomas Wu - San Francisco CA, US Zemin Zhang - Foster City CA, US
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Frederic J. de Sauvage - Foster City CA, US Robert D. Klein - Palo Alto CA, US Heidi S. Phillips - San Carlos CA, US Arnon Rosenthal - Burlingame CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 14/71
US Classification:
530350, 530402
Abstract:
The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i. e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i. e. , autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
Belinda Cairns - Burlingame CA, US Ruihuan Chen - Palo Alto CA, US Gretchen Frantz - San Francisco CA, US Kenneth J. Hillan - San Francisco CA, US Hartmut Koeppen - Berkeley CA, US Heidi S. Phillips - Palo Alto CA, US Paul Polakis - Burlingame CA, US Susan D. Spencer - Tiburon CA, US Victoria Smith - Burlingame CA, US P. Mickey Williams - Half Moon Bay CA, US Thomas D. Wu - San Francisco CA, US Zemin Zhang - Foster City CA, US
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Compositions And Methods For The Diagnosis And Treatment Of Tumor
Gretchen Frantz - San Francisco CA, US Kenneth J. Hillan - San Francisco CA, US Heidi Phillips - San Carlos CA, US Paul Polakis - Burlingame CA, US Susan D. Spencer - Tiburon CA, US P. Mickey Williams - Half Moon Bay CA, US Thomas D. Wu - San Francisco CA, US Zemin Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
G01N 33/53
US Classification:
435 71
Abstract:
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Compositions And Methods For The Diagnosis And Treatment Of Tumor
Gretchen Frantz - San Francisco CA, US Kenneth J. Hillan - San Francisco CA, US Heidi Phillips - San Carlos CA, US Paul Polakis - Burlingame CA, US Susan D. Spencer - Tiburon CA, US P. Mickey Williams - Half Moon Bay CA, US Thomas D. Wu - San Francisco CA, US Zemin Zhang - Foster City CA, US
Assignee:
Genetech, Inc. - South San Francisco CA
International Classification:
G01N 33/53
US Classification:
435 71
Abstract:
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Compositions And Methods For The Diagnosis And Treatment Of Tumors Of Glial Origin
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumors of glial origin in mammals and to methods of using those compositions of matter for the same.
Compositions And Methods For The Diagnosis And Treatment Of Tumor
Belinda Cairns - Burlingame CA, US Ruihuan Chen - Foster City CA, US Gretchen Frantz - San Francisco CA, US Kenneth J. Hillan - San Francisco CA, US Hartmut Koeppen - Berkeley CA, US Heidi S. Phillips - Palo Alto CA, US Paul Polakis - Burlingame CA, US Susan D. Spencer - Tiburon CA, US Victoria Smith - Burlingame CA, US P. Mickey Williams - Half Moon Bay CA, US Thomas D. Wu - San Francisco CA, US Zemin Zhang - Foster City CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12Q 1/68
US Classification:
435 61
Abstract:
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Methods Of Increasing Distribution Of Therapeutic Agents
Krys Bankiewicz - Piedmont CA, US John Hamilton - Washington DC, US Edward Oldfield - Philomont VA, US Heidi Phillips - Palo Alto CA, US
International Classification:
A61K038/19 A61K031/727
US Classification:
424/085100, 514/056000
Abstract:
The present invention provides a method of increasing the volume of distribution of a therapeutic agent in a tissue in a subject during localized delivery comprising administering to the tissue in the subject a therapeutic agent and a facilitating agent, whereby the inclusion of the facilitating agent increases the volume of distribution of the therapeutic agent in the tissue. The invention also provides a method of increasing the pharmacological activity of a therapeutic agent in a tissue in a subject during localized delivery, comprising administering to the tissue in the subject a therapeutic agent and a facilitating agent, whereby the inclusion of the facilitating agent increases the pharmacological activity of the therapeutic agent in the tissue.
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