Helena C Zec from Somerville, MA, age 41

System And Method For Screening A Library Of Samples
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US Patent:

20130165346, Jun 27, 2013
Filed:

Dec 7, 2012
Appl. No.:

13/708510
Inventors:

The Johns Hopkins University - Baltimore MD, US
Tushar Dnyandeo Rane - Baltimore MD, US
Helena Claire Zec - Baltimore MD, US
Assignee:

The Johns Hopkins University - Baltimore MD
International Classification:

G01N 1/28
US Classification:

506 12, 506 39
Abstract:

A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.

System And Method For Screening A Library Of Samples
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US Patent:

20190154715, May 23, 2019
Filed:

Jan 18, 2019
Appl. No.:

16/251744
Inventors:

- Baltimore MD, US
- Johnston IA, US
Helena Claire Zec - Baltimore MD, US
Assignee:

The Johns Hopkins University - Baltimore MD
Pioneer Hi-Bred International, Inc. - Johnston IA
International Classification:

G01N 35/08
G01N 35/00
B01L 3/02
B01L 3/00
B01J 19/00
G01N 1/28
Abstract:

A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.

Impedance Based Feedback Control Of Microfluidic Valves
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US Patent:

20180304267, Oct 25, 2018
Filed:

Apr 19, 2017
Appl. No.:

15/491743
Inventors:

- Baltimore MD, US
- Johnston IA, US
Yi-Fan Hsieh - Baltimore MD, US
Helena C. Zec - Baltimore MD, US
Aniruddha Kaushik - Baltimore MD, US
Kuangwen Hsieh - Germantown MD, US
Yue Yun - Johnston IA, US
Assignee:

The Johns Hopkins University - Baltimore MD
Pioneer Hi-Bred International, Inc. - Johnston IA
International Classification:

B01L 3/00
Abstract:

A microfluidic system includes a microfluidic chip including a channel layer and a fluid control layer operatively connected to the channel layer, the channel layer having one or more fluid channels. The one or more channels are configured to contain a plurality of droplets. A valve control system is provided to control flow of fluid through the one or more fluid channels in the channel layer. The microfluidic system also includes a droplet impedance detection and feedback control system operatively connected to the valve control system. The droplet impedance detection and feedback control system is configured to detect at least a position of at least one droplet in a fluid channel and to send a signal to the valve control system to operate a particular valve at a particular time based on the detected position of the at least one droplet.

System And Method For Screening A Library Of Samples
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US Patent:

20170261527, Sep 14, 2017
Filed:

May 4, 2016
Appl. No.:

15/146319
Inventors:

- Baltimore MD, US
- Johnston IA, US
Helena Claire Zec - Baltimore MD, US
Assignee:

The Johns Hopkins University - Baltimore MD
Pioneer Hi-Bred International, Inc. - Johnston IA
International Classification:

G01N 35/08
G01N 35/00
B01L 3/02
B01L 3/00
Abstract:

A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.

System And Device For High Throughput Generation Of Combinatorial Droplets And Methods Of Use
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US Patent:

20160332163, Nov 17, 2016
Filed:

Jan 26, 2015
Appl. No.:

15/112334
Inventors:

- Baltimore MD, US
Tushar Dnyandeo Rane - Los Angeles CA, US
Helena Claire Zec - Baltimore MD, US
Assignee:

The Johns Hopkins University - Baltimore MD
International Classification:

B01L 3/00
B01J 19/00
Abstract:

The present invention is directed to a microfluidic system comprising a microfluidic chip and a method of performing a chemical assay wherein a sample is processed into multiple daughter droplets and said daughter droplets are incubated with varying reagents. The properties of these droplets can be detected to provide assay data.

Helena C Zec