- Somerset NJ, US - University MS, US Michael Andrew REPKA - Oxford MS, US Jun-Bom PARK - Seoul, KR Roshan Vijay TIWARI - Hillsborough NJ, US Hemlata Gunga PATIL - Hillsborough NJ, US Wenli LU - Shanghai, CN
Assignee:
CATALENT PHARMA SOLUTIONS INC. - Somerset NJ UNIVERSITY OF MISSISSIPPI - University MS
A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.
Systems And Methods For Preparing Solid Lipid Nanoparticles
- University MS, US Hemlata Gunga Patil - University MS, US Soumyajit Majumdar - Oxford MS, US Vijay I. Kulkarni - University MS, US
International Classification:
A61K 9/51
Abstract:
A continuous process for the manufacture of solid lipid nanoparticles includes preparing a pre-emulsion comprising a lipid and continuously passing the pre-emulsion through a high pressure homogenizer.