Heng Y Chen

US Patent:

20120177568, Jul 12, 2012

Filed:

Oct 10, 2011

Appl. No.:

13/270207

Inventors:

John C. WILLIAMS - Monrovia CA, US
David A. Horne - Duarte CA, US
Yuelong Ma - Duarte CA, US
Heng Wei Chen - Foster City CA, US

International Classification:

A61K 51/10
C07K 7/08
C07K 19/00
C12N 9/96
C07K 16/44
A61K 39/395
A61K 49/00
C12N 5/09
C07K 7/06
A61P 37/02
A61P 39/04
C07K 4/00
C07K 1/14
B82Y 5/00

US Classification:

424 149, 530300, 530327, 5303873, 530408, 530322, 435188, 5303871, 5303879, 4241331, 424 91, 424 96, 435375, 530326, 977773, 977915, 977927

Abstract:

Meditope variants and methods for their use are provided herein. A meditope variant as described herein comprises a peptide having a sequence CQFDLSTRRLKC (SEQ ID NO:1) or CQYNLSSRALKC (SEQ ID NO:2) that has one or more modifications at of least one amino acid residue of the sequence. Multivalent meditope variant tethering entities are also provided. Such entities may include two or more meditopes coupled via a long linker, multivalent scaffold, biotin-streptavidin, or IgG Fc domain. Further, methods of treating, imaging or diagnosing a disease or condition are provided. Such methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, the pharmaceutical compound comprising an antibody-meditope complex; a multivalent tethering agent in combination with a monoclonal antibody or functional fragment thereof; or a combination thereof.