Henry Y Li

US Patent:

20040071708, Apr 15, 2004

Filed:

Sep 26, 2002

Appl. No.:

10/255775

Inventors:

Gisela Claassen - San Diego CA, US
Henry Li - Carlsbad CA, US
Jack Barber - San Diego CA, US

Assignee:

Immusol, Inc. - San Diego CA

International Classification:

G01N033/574
A61K048/00
A61K039/395

US Classification:

424/155100, 514/044000, 435/007230

Abstract:

The present invention discloses compositions, systems and methods for identifying anti-cancer agents using doth in vitro and in vivo techniques. Embodiments include the screening of combinatorial libraries of peptides, antibodies, and small organic molecules as well as siRNAs, ribozymes and antisense nucleotides directed against nucleic acids encoding the GPR 39 protein.

US Patent:

20040115815, Jun 17, 2004

Filed:

Jul 23, 2003

Appl. No.:

10/628587

Inventors:

Henry Li - Carlsbad CA, US
Jon Chatterton - San Diego CA, US
Ning Ke - San Diego CA, US
Kristina Rhoades - San Diego CA, US
Flossie Wong-Staal - San Diego CA, US

Assignee:

Immusol, Inc. - San Diego CA

International Classification:

C12N015/861
C12N007/00

US Classification:

435/456000, 435/320100, 435/235100

Abstract:

The present invention relates to methods and compositions for the elucidation of gene function and the identification of novel genes. Specifically, the present invention relates to methods and compositions for improved functional genomic screening, functional inactivation of specific essential or non-essential genes, and identification of genes that are modulated in response to specific stimuli or encode recognizable phenotypic traits. In particular, the compositions of the present invention include, but are not limited to, expression cassettes comprising a novel polymerase primer hairpin linker that allows rapid construction of a single transcriptional unit encoding both strands of a hairpin siRNA, regardless of sequence. In addition, the present invention includes libraries comprising the expression cassettes of the invention, including vectors for transforming cells, such as replication-deficient retroviral vectors. The invention also includes methods for the production and screening of siRNA libraries, as well as therapeutic uses for the siRNAs expressed in accordance with the invention.

US Patent:

20040146858, Jul 29, 2004

Filed:

Jul 23, 2003

Appl. No.:

10/626512

Inventors:

Henry Li - Carlsbad CA, US
Jon Chatterton - San Diego CA, US
Ning Ke - San Diego CA, US
Flossie Wong-Staal - San Diego CA, US

Assignee:

Immusol, Inc. - San Diego CA

International Classification:

C12Q001/70
C07H021/04
C12N007/00
C12N015/86

US Classification:

435/005000, 435/456000, 435/235100, 536/023720

Abstract:

The present invention relates to methods and compositions for the elucidation of gene function and the identification of novel genes. Specifically, the present invention relates to methods and compositions for improved functional genomic screening, functional inactivation of specific essential or non-essential genes, and identification of genes that are modulated in response to specific stimuli or encode recognizable phenotypic traits. In particular, the compositions of the present invention include, but are not limited to, expression cassettes comprising a novel dual promoter transcription system, that utilizes modified promoters, preferably containing complementary termination sequences, positioned across a coding sequence and in opposite orientation to each other. In addition, the present invention includes libraries comprising the expression cassettes of the invention, including vectors for transforming cells, such as replication-deficient retroviral vectors. The invention also includes methods for the production and screening of dsRNA/siRNA libraries, as well as therapeutic uses for the siRNAs expressed in accordance with the invention.

US Patent:

20050026172, Feb 3, 2005

Filed:

Feb 10, 2004

Appl. No.:

10/776399

Inventors:

Henry Li - Carlsbad CA, US
Jon Chatterton - San Diego CA, US
Wufang Fan - San Diego CA, US
Ning Ke - San Diego CA, US
Flossie Wong-Staal - San Diego CA, US

Assignee:

Immusol, Inc. - San Diego CA

International Classification:

C12Q001/68
C07H021/02

US Classification:

435006000, 536023100

Abstract:

Libraries for generating small interfering RNA (siRNA) are provided where the members of the library are optimized to inhibit the expression of genes that encode a predetermined family of proteins. The members of the library target at least mRNA encoding all members of the family of proteins. Methods for generating siRNA libraries of the present invention are also provided.

US Patent:

20060234249, Oct 19, 2006

Filed:

Apr 15, 2005

Appl. No.:

11/106990

Inventors:

Ning Ke - San Diego CA, US
De-Hua Yu - San Diego CA, US
Aaron Albers - Berkeley CA, US
Gisela Claassen - San Diego CA, US
Henry (Qi-Xiang) Li - Carlsbad CA, US
Flossie Wong-Staal - San Diego CA, US

Assignee:

Immusol Incorporated - San Diego CA

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The present invention provides novel assays for assessing cancerous cell growth. The invention is useful for the identification and validation of oncogenes and tumor suppressors, as well as for the identification and validation of therapeutic compounds for the treatment of cancer.

US Patent:

20070087984, Apr 19, 2007

Filed:

Aug 24, 2004

Appl. No.:

10/570911

Inventors:

Xiuyuan Hu - San Diego CA, US
Henry Li - Carlsbad CA, US
Ning Ke - San Diego CA, US
Mirta Grifman - San Diego CA, US
Cheryl Rogers - San Diego CA, US
Kristen Difife - San Diego CA, US
Cellia Habita - La Jolla CA, US
Wufang Fan - San Diego CA, US
Kristina Rhoades - Crowley TX, US
Philip Tan - San Diego CA, US
Richard Tritz - San Diego CA, US
Flossie Wong-Staal - San Diego CA, US

International Classification:

A61K 48/00

US Classification:

514044000

Abstract:

The present invention is directed to methods of identifying agents useful for inhibiting cancer cells. The agents bind to one of the proteins described herein, or to a gene or mRNA encoding such protein. The invention is also directed to methods for inhibiting cancer cells by administering an agent that binds to one of the proteins described herein, or to a gene or mRNA encoding such protein.

US Patent:

20070184459, Aug 9, 2007

Filed:

Feb 3, 2006

Appl. No.:

11/351522

Inventors:

Henry Li - Carlsbad CA, US
Ning Ke - San Diego CA, US
Mirta Grifman - San Diego CA, US
Gisela Claasen - San Diego CA, US
Xiuyuan Hu - San Diego CA, US
Kristen Defife - San Diego CA, US
Cellia Habita - La Jolla CA, US
Wufang Fan - San Diego CA, US
Kristina Rhoades - Crowley TX, US
Philip Tan - San Diego CA, US
Flossie Wong-Staal - San Diego CA, US

International Classification:

C12Q 1/68
G01N 33/574
C12N 15/09

US Classification:

435006000, 435007230, 435455000

Abstract:

The present invention provides methods for identifying agents useful for inhibiting cancer cells by binding to various nuclear receptor proteins, or to the genes or RNA encoding such proteins.

US Patent:

20080281105, Nov 13, 2008

Filed:

Jan 18, 2006

Appl. No.:

11/814036

Inventors:

James E. Macdonald - Encinitas CA, US
Michelle K. Hysell - San Diego CA, US
Dehua Yu - San Diego CA, US
Henry Li - Carlsbad CA, US
Flossie Wong-Staal - San Diego CA, US

Assignee:

IMMUSOL INCORPORATED - San Diego CA

International Classification:

C07D 215/38
C07D 401/06

US Classification:

546171, 546176

Abstract:

The present invention relates generally to the synthesis of novel quinolinium salts and derivative compounds. Such salts and compounds are useful for inhibiting the growth of cancer cells.