Henry C Kao Susan Lin

US Patent:

7585838, Sep 8, 2009

Filed:

Aug 14, 2007

Appl. No.:

11/838631

Inventors:

Henry C. Lin - Albuquerque NM, US
Mark Pimentel - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61K 38/00

US Classification:

514 2

Abstract:

Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis of any of those diagnostic categories. Also disclosed is a method of treating these disorders, and other disorders caused by SIBO, that involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of anti-microbial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. The method improves symptoms, including hyperalgesia related to SIBO and disorders caused by SIBO. Also disclosed is a kit for the diagnosis or treatment of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, or Crohn's disease.

US Patent:

7605240, Oct 20, 2009

Filed:

Aug 14, 2007

Appl. No.:

11/838672

Inventors:

Henry C. Lin - Albuquerque NM, US
Mark Pimentel - Los Angeles CA, US

Assignee:

Cedara-Sinai Medical Center - Los Angeles CA

International Classification:

C07G 11/00

US Classification:

536 168

Abstract:

Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis of any of those diagnostic categories. Also disclosed is a method of treating these disorders, and other disorders caused by SIBO, that involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of anti-microbial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. The method improves symptoms, including hyperalgesia related to SIBO and disorders caused by SIBO. Also disclosed is a kit for the diagnosis or treatment of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, or Crohn's disease.

US Patent:

7935799, May 3, 2011

Filed:

Aug 28, 2009

Appl. No.:

12/550303

Inventors:

Henry C. Lin - Albuquerque NM, US
Mark Pimentel - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

C07G 11/00

US Classification:

536 168

Abstract:

Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis of any of those diagnostic categories. Also disclosed is a method of treating these disorders, and other disorders caused by SIBO, that involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of anti-microbial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. The method improves symptoms, including hyperalgesia related to SIBO and disorders caused by SIBO. Also disclosed is a kit for the diagnosis or treatment of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, or Crohn's disease.

US Patent:

7999340, Aug 16, 2011

Filed:

Mar 7, 2007

Appl. No.:

11/715799

Inventors:

Giuseppe Rossi - Los Angeles CA, US
Lester Kozlowski - Simi Valley CA, US
Henry Lin - San Jose CA, US
John Richardson - Newbury Park CA, US
Gregory Chow - Camarillo CA, US
Gaurang Patel - Newbury Park CA, US

Assignee:

AltaSens, Inc. - Westlake Village CA

International Classification:

H01L 31/232

US Classification:

257431, 257184, 257187, 257259, 257292, 257461, 257222, 257432, 257443, 257455, 257463, 257466, 257E31119, 257E31127, 257E25005, 438 39, 438 81, 438164

Abstract:

An apparatus and method for forming optical black pixels having uniformly low dark current. Optical Black opacity is increased without having to increase Ti/TiN layer thickness. A hybrid approach is utilized combining a Ti/TiN OB layer in conjunction with in-pixel metal stubs that further occlude the focal radius of each pixel's incoming light beam. Additional metal layers can be used to increase the opacity into the infrared region.

US Patent:

8110177, Feb 7, 2012

Filed:

Apr 27, 2010

Appl. No.:

12/768531

Inventors:

Henry C. Lin - Albuquerque NM, US
Mark Pimentel - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61K 49/00
A61K 45/00
A61K 47/00

US Classification:

424 92, 424 91, 424116, 4242781, 424439, 426 5, 426 71, 426658, 426800, 426801, 435 4, 435 29

Abstract:

Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.

US Patent:

8197805, Jun 12, 2012

Filed:

Mar 28, 2011

Appl. No.:

13/073169

Inventors:

Henry C. Lin - Albuquerque NM, US
Mark Pimentel - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A01N 63/00
A61K 35/00

US Classification:

424 931, 424114, 424116

Abstract:

Disclosed is a method of diagnosing autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis an autoimmune disease. Also disclosed is a method of treating these autoimmune diseases, which involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of antimicrobial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. Also disclosed is a kit for the diagnosis or treatment of autoimmune diseases.

US Patent:

8388935, Mar 5, 2013

Filed:

Dec 9, 2011

Appl. No.:

13/315671

Inventors:

Henry C. Lin - Albuquerque NM, US
Mark Pimentel - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61K 49/00
A61K 35/00
A61K 45/00

US Classification:

424 92, 424 91, 424116, 4242781, 424439, 426 5, 426 71, 426658, 426800, 435 5, 435 29

Abstract:

Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.

US Patent:

8562952, Oct 22, 2013

Filed:

Mar 1, 2013

Appl. No.:

13/782504

Inventors:

Henry C. Lin - Albuquerque NM, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61K 49/00
A61K 35/00
A61K 45/00

US Classification:

424 92, 424 91, 424116, 4242781, 424439, 426 5, 426 71, 426658, 426800, 435 5, 435 29

Abstract:

Various embodiments of the invention disclosed herein include methods of inducing satiety a mammal in need thereof. Also disclosed are methods of inducing satiety in an obese mammal. Additionally disclose are method of suppressing appetite in a mammal in need thereof. Further disclosed are methods of treating obesity. The methods described herein involve the administration of serotonin, a serotonin agonist or a serotonin re-uptake inhibitor to the mammal.