Herbert A Fritsche

US Patent:

6855554, Feb 15, 2005

Filed:

Sep 5, 2002

Appl. No.:

10/236027

Inventors:

Herbert A. Fritsche - Houston TX, US
Henry M. Kuerer - Houston TX, US

Assignee:

Board of Regents, The University of Texas Systems - Austin TX

International Classification:

G01N033/48

US Classification:

436 64, 436 63, 436 86, 436177, 436178, 204450, 204456, 204461

Abstract:

Systematic comparisons of breast ductal fluid samples obtained by nipple aspiration from women with unilateral breast cancer revealed significant differences in ductal fluid protein expression between the breast with cancer and the breast without cancer in each patient. This study demonstrates that breast ductal fluid contains over 1000 separate protein species and suggests that ductal fluids from breast cancer patients may be useful for high-throughput biomarker discovery.

US Patent:

20030211624, Nov 13, 2003

Filed:

Nov 20, 2002

Appl. No.:

10/301512

Inventors:

Ira Goldknopf - The Woodlands TX, US
Helen Park - The Woodlands TX, US
Herbert Fritsche - Houston TX, US
Henry Kuerer - Houston TX, US

Assignee:

Board of Regents, The University of Texas System

International Classification:

G01N033/00

US Classification:

436/086000, 436/173000

Abstract:

A method of diagnosing a cancerous condition in a female includes analyzing ductal secretions from each breast of a female subject in which differences in the protein profiles of the two samples are indicative of a cancerous condition. Protein samples are preferable analyzed by two dimensional gel electrophoresis or by microarrays. Identification of cancer markers and monitoring progression and treatment of cancers, and especially breast cancer are also dislcosed.

US Patent:

20050009114, Jan 13, 2005

Filed:

May 14, 2004

Appl. No.:

10/846344

Inventors:

Martin Korbling - Houston TX, US
Zeev Estrov - Houston TX, US
Herbert Fritsche - Houston TX, US

International Classification:

G01N033/53
G01N033/567
C12N005/08

US Classification:

435007200, 435372000

Abstract:

The present invention provides a method for assessing stem cell transplant in a protein-containing sample using multi-dimensional protein separation. Such multi-dimensional separation techniques include chromatography, electrophoresis and mass spectrometry. A protein-containing sample may comprise body fluids such as blood and serum but may also include a cell, tissue or organ. Identification of a protein present in the donor and the transplant recipient but not in the recipient sample before transplant indicates that the stem cell is grafted.

US Patent:

20100099085, Apr 22, 2010

Filed:

Jul 30, 2007

Appl. No.:

12/376148

Inventors:

Richard Babaian - Houston TX, US
Herbert Fritsche - Houston TX, US
Li-Ying Yang - Bellaire TX, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

We disclose a method of screening a mammal for a cancer associated with methylation of promoters of tumor-suppressor genes by collecting a sample of a body fluid or tissue of the mammal containing free DNA; isolating the free DNA from the sample; amplifying at least a portion of the promoter of each of a plurality of turner-suppressor genes associated with the cancer from the free DNA, to yield a plurality of amplified promoters; and quantifying methylation of each of the plurality of amplified promoters, to yield a methylation quantity. The method can have a high sensitivity and high specificity and can thus reduce the proportion of unneeded biopsies. It can also be performed with minimal invasiveness and discomfort to a patient.

US Patent:

60701269, May 30, 2000

Filed:

Jun 12, 1998

Appl. No.:

9/097078

Inventors:

William J. Kokolus - Kenmore NY
Herbert A. Fritsche - Houston TX
Dennis A. Johnston - Houston TX

International Classification:

C07K 1400

US Classification:

702 19

Abstract:

The present invention relates to identifying protein epitopes and more particularly to a novel method for identifying, determining the location, optimal length of amino acid residues and immunobiological potency of protein epitopes by applying a custom negative cosine function fit algorithm to a protein hydropathy scale. This fit analysis is supplemented with experimental immunobiological data. The amino acid sequence of the protein epitopes of the present invention exhibit a hydrophobic-hydrophilic-hydrophobic hydropathy pattern of an approximately fixed length in a given protein.

US Patent:

58079785, Sep 15, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/472228

Inventors:

William J. Kokolus - Houston TX
Herbert A. Fritsche - Houston TX
Dennis A. Johnston - Houston TX

International Classification:

A61K 39385
A61K 3939
C07K 704
C07K 1447

US Classification:

530300

Abstract:

Peptides derived from prostate specific antigen (PSA) that correspond to the immunodominant epitopes found in the native antigen are disclosed. These peptides were identified using a method that predicts continuous, immunodominant epitopes. Anti-PSA antibodies, methods for their production and their use in diagnostic assays also are disclosed.

US Patent:

63264714, Dec 4, 2001

Filed:

Sep 4, 1998

Appl. No.:

9/146831

Inventors:

William J. Kokolus - Kenmore NY
Herbert A. Fritsche - Houston TX
Dennis A. Johnston - Houston TX

International Classification:

C07K 1618
C07K 1606
C07K 1630
C07K 1640
C07K 708

US Classification:

5303879

Abstract:

Peptides derived from prostate specific antigen (PSA) that correspond to the immunodominant epitopes found in the native antigen are disclosed. These peptides were identified using a method that predicts continuous, immunodominant epitopes. Anti-PSA antibodies, methods for their production and their use in diagnostic assays also are disclosed.