Herbert F Oettgen from 284 Kendal Dr, Kennett Sq, PA 19348, Phone: (203)9431234

Method For Detecting The Presence Of G.sub.d3 Ganglioside
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US Patent:

45073910, Mar 26, 1985
Filed:

Apr 2, 1982
Appl. No.:

6/365065
Inventors:

Clifford S. Pukel - Flushing NY
Kenneth O. Lloyd - Bronx NY
Luiz R. Travassos - Sao Palo, BR
Wolfgang G. Dippold - Mainz, DE
Herbert F. Oettgen - New Canaan CT
Lloyd J. Old - New York NY
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

G01N 3354
C12N 1500
US Classification:

436504
Abstract:

Mouse monoclonal antibody AbR. sub. 24 (Dippold et al. , Proc. Natl. Acad. Sci. 77:6114-6118, 1980) has a high degree of specificity for human melanoma cells when tested on viable cultured cells using the PA-MHA serological assay. The antigen detected by this antibody has been isolated from melanoma cells and shown to be G. sub. D3 ganglioside by compositional and partial structural analysis and by comparison with authentic G. sub. D3 by thin layer chromatography (TLC). AbR. sub. 24 reacts with authentic G. sub. D3, but not with any other ganglioside tested. Using TLC and reactivity with AbR. sub. 24, a wide range of cells and tissues was examined for the presence of G. sub. D3. A new serological assay, termed glycolipid-mediated immune adherence (GMIA), was devised for assaying the reactivity of AbR. sub. 24 with gangliosides. Melanomas (cultured cells or tumor tissue) were shown to have T. sub. D3 and G. sub.

Cell-Surface Glycoproteins Of Human Sarcomas
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US Patent:

50595237, Oct 22, 1991
Filed:

May 2, 1988
Appl. No.:

7/189238
Inventors:

Wolfgang J. Rettig - New York NY
H. Richard Beresford - Century Island NY
Herbert F. Oettgen - New Canaan CT
Myron R. Melamed - Dobbs Ferry NY
Lloyd J. Old - New York NY
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

G01N 3353
G01N 33567
C12N 1500
C07K 1514
US Classification:

435 723
Abstract:

This invention provides a method of identifying mesenchymal tissues as normal, proliferatively active or malignant. This invention also provides a method of distinguishing subsets of sarcomas with distinctive antigenic phenotypes. This invention also provides a method of diagnosing mesenchymal tumors. Finally, this invention provides a monoclonal antibody designated G171 and the hybridoma cell line producing said monoclonal antibody (ATCC No. HB9254).

Monoclonal Antibodies For Detection Of An H (O) Blood Group Antigen
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US Patent:

46787470, Jul 7, 1987
Filed:

Feb 28, 1983
Appl. No.:

6/470815
Inventors:

Kenneth O. Lloyd - Bronx NY
Lloyd J. Old - New York NY
Karl-Anders Karlsson - Gothenburg, SE
Goran Larson - Gothenburg, SE
Nicklas Stromberg - Gothenburg, SE
Jan Thurin - Gothenburg, SE
Bernd R. Anger - Kreiensen, DE
Herbert F. Oettgen - New Canaan CT
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

G01N 5300
C12N 1500
US Classification:

435 7
Abstract:

Monoclonal antibodies recognizing the difucosyl-type-2-H antigen on human cells and a method of producing said antibodies are disclosed. The monoclonal antibodies are useful in blood typing and in diagnosis of blood disorders and malignancies involving loss or gain of this H antigen.

Monoclonal Antibodies To Human Lung Cancers And Method
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US Patent:

48659983, Sep 12, 1989
Filed:

Aug 10, 1987
Appl. No.:

7/083723
Inventors:

Hans-Joachim Feickert - New York NY
Wolfgang Rettig - New York NY
Karen Chorney - New York NY
Carlos Cordon-Cardo - New York NY
Myron R. Melamed - Scarsdale NY
Kenneth O. Lloyd - Bronx NY
Herbert F. Oettgen - New Canaan CT
Lloyd J. Old - New York NY
Bernd Anger - Ulm, DE
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

G01N 33574
G01N 33577
C12N 500
US Classification:

436548
Abstract:

A panel of monoclonal antibodies produced from normal human lung fibroblasts and human lung tumors as immunogen is used to diagnose the presence of lung tumors and differentiate between those which are benign and those which are cancerous.

Monoclonal Antibodies To Cell Surface Antigens Of Human Renal Cancer
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US Patent:

46507566, Mar 17, 1987
Filed:

Aug 31, 1981
Appl. No.:

6/297814
Inventors:

Lloyd J. Old - New York NY
Kenneth O. Lloyd - Bronx NY
Herbert F. Oettgen - New Canaan CT
Willet F. Whitmore - New York NY
Jerzy Szkudlarek - Wroclaw, PL
Connie L. Finstad - New York NY
Donna Morrissey - New York NY
Shun-ichiro Ogata - Nagoya, JP
Ryuzo Ueda - Nagoya, JP
Assignee:

Sloan Kettering Institute for Cancer Research - NY
International Classification:

C12P 2100
C12N 500
C12N 1500
C12R 191
US Classification:

435 68
Abstract:

The preparation and use of monoclonal antibodies to human renal tumor cells is described. The monoclonal antibodies bind to glycoproteins of 160Kd, 120Kd and 115Kd, a glycolipid, a HLA heavy chain, group A blood and group B blood antigens.

Human Monoclonal Antibodies To Cytokeratin
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US Patent:

47270217, Feb 23, 1988
Filed:

Jun 1, 1984
Appl. No.:

6/616271
Inventors:

Richard J. Cote - New York NY
Timothy M. Thomson - New York NY
Alan N. Houghton - New York NY
Herbert F. Oettgen - New Canaan CT
Lloyd J. Old - New York NY
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

G01N 5300
G01N 3353
C12N 500
A61K 3900
US Classification:

435 7
Abstract:

Human monoclonal antibodies (HmAbs) capable of reacting with cytokeratin are disclosed. It has been found that HmAbs De8, M54, M307, Hull, C29, Hu22 and Pa24 may be used to detect these cytoskeletal proteins in various cells. By means of these HmAbs the embryological origin of cells may be determined. This information may be used to determine the possible tissue source of metastasized tumors and greatly affects the management of these cancers.

Monoclonal Antibodies To Cell Surface Antigens Of Human Teratocarcinomas
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US Patent:

47628006, Aug 9, 1988
Filed:

Apr 26, 1984
Appl. No.:

6/604080
Inventors:

Wolfgang Rettig - NY NY
Carolos Cordon-Cardo - NY NY
Herbert F. Oettgen - New Canaan CT
Lloyd J. Old - New York NY
Kenneth O. Lloyd - New York NY
Jennifer Ng - New York NY
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

C12N 500
G01N 33534
G01N 33533
A61K 39395
US Classification:

436548
Abstract:

Antibody-producing hybridoma cell lines made by fusion of NS/1 cells with spleen cells of mice after immunization with human teratocarcinoma cells are presented. Monoclonal antibodies from these cell lines recognize the K4, K2 and P12 antigenic systems and are thus useful in detecting and differentiating between normal and cancerous cells. These monoclonal antibodies are especially useful in pathologic analysis of human tumors, especially teratocarcinomas.

Human Monoclonal Antibodies To Cancer Cells
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US Patent:

46135766, Sep 23, 1986
Filed:

Mar 9, 1983
Appl. No.:

6/473830
Inventors:

Richard J. Cote - New York NY
Donna M. Morrissey - New York NY
Alan N. Houghton - New York NY
Edward J. Beattie - New York NY
Herbert F. Oettgen - New Canaan CT
Lloyd J. Old - New York NY
Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:

C12N 1500
C12N 500
G01N 3353
C12P 2100
US Classification:

436548
Abstract:

Hybridomas which produce human monoclonal antibodies are disclosed. The hybridomas are formed by fusing lymphocytes from individuals with various cancers to an immortal cell line, such as a myeloma, from, e. g. , a human cell line, or a mouse cell line.