SHOJI HAMANAKA - YOKOSUKA, JP HIROYUKI KUBO - CARLSBAD CA, US IWAO NOZAWA - CARLSBAD CA, US
International Classification:
A61K048/00 C07H021/04
US Classification:
514/044000, 536/023500
Abstract:
The invention features antisense oligonucleotide molecules that specifically bind polynucleotides encoding IL-15. The present invention provides antisense oligonucleotides capable of inhibiting IL-15 expression, and methods of use thereof to reduce activity of IL-15 in tissues in order to treat diseases such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, chronic liver disease, ulcerative colitis and cell proliferative disorders.