Hong Cheng

US Patent:

6452050, Sep 17, 2002

Filed:

Mar 21, 2000

Appl. No.:

09/531737

Inventors:

Carmen M. Baldino - Lexington MA
David L. Coffen - Cambridge MA
Stewart D. Chipman - Reading MA
Hong Cheng - Brighton MA

Assignee:

ArQule, Inc. - Woburn MA

International Classification:

C07C23307

US Classification:

564123, 564502

Abstract:

The invention is based on new methods for making and using compounds and arrays of novel -ketoamides, and the arrays and compounds made by these methods. These novel compounds are potential inhibitors of proteolytic enzymes, particularly cysteine proteases such as cruzain. Application of the new methods has led to the identification of a number of new inhibitors, from amongst an array of about 38,000 -ketoamide derivatives, having specific activity against three cysteine proteases: cruzain, papain, and cathepsin B. These compounds and other compounds identified by the methods described herein can be useful, for example, in developing pharmaceutical agents for the treatment of diseases (e. g. , Chagas disease) associated with these proteases. Although the disclosed compounds have specific activity for cruzain, papain, cathepsin B, the methods described herein can also be used to identify inhibitors of other proteases.

US Patent:

20100170829, Jul 8, 2010

Filed:

Dec 18, 2009

Appl. No.:

12/642453

Inventors:

Man Kit Ng - Annandale NJ, US
Glen B. Brons - Phillipsburg NJ, US
Steven W. Levine - Flemington NJ, US
Kevin Mallory - Clinton NJ, US
Hong Cheng - East Brunswick NJ, US
Patrick Brant - Seabrook TX, US
Donna J. Crowther - Seabrook TX, US

Assignee:

ExxonMobil Research and Engineering Company - Annandale NJ

International Classification:

C10G 75/04
C09K 3/00
C08G 69/26

US Classification:

208 48AA, 196 46, 252384, 528332

Abstract:

The present invention provides a method for reducing fouling, including particulate-induced fouling, in a hydrocarbon refining process including the steps of providing a crude hydrocarbon for a refining process; adding at least one polyalkyl succinic anhydride derivative additive disclosed herein. The additive can be complexed with a boronating agent, such as boric acid, to yield a boron-containing polyalkyl succinic anhydride derivative.

US Patent:

20110147275, Jun 23, 2011

Filed:

Dec 18, 2009

Appl. No.:

12/642606

Inventors:

Man Kit NG - Annandale NJ, US
Glen B. Brons - Phillipsburg NJ, US
Steven W. Levine - Flemington NJ, US
Kevin Mallory - Clinton NJ, US
Hong Cheng - East Brunswick NJ, US
Patrick Brant - Seabrook TX, US
Donna J. Crowther - Seabrook TX, US

Assignee:

ExxonMobil Research and Engineering Company - Annandale NJ

International Classification:

C10G 29/20
C08G 73/00

US Classification:

208289, 525379, 5253337, 196 46

Abstract:

The present invention provides a method for reducing fouling, including particulate-induced fouling, in a hydrocarbon refining process including the steps of providing a crude hydrocarbon for a refining process and adding an antifouling agent containing a polymer base unit and a polyamine group to the crude hydrocarbon. The antifouling agent can be obtained by reacting an epoxidation reagent with a vinyl-terminated polymer, such as polypropylene or poly(ethylene-co-propylene), to form a terminal epoxy group, followed by reacting a polyamine with the epoxy group.

US Patent:

20130008830, Jan 10, 2013

Filed:

Jul 5, 2011

Appl. No.:

13/176082

Inventors:

Man Kit NG - Annandale NJ, US
Glen B. BRONS - Phillipsburg NJ, US
David T. FERRUGHELLI - Flemington NJ, US
Hong CHENG - Bridgewater NJ, US
Kevin MALLORY - Clinton NJ, US
Emmanuel Ulysse - Maplewood NJ, US
John R. Hagadorn - Houston TX, US
Donna J. CROWTHER - Seabrook TX, US
Patrick BRANT - Seabrook TX, US

Assignee:

EXXONMOBIL RESEARCH AND ENGINEERING COMPANY - Annandale NJ

International Classification:

C10G 29/20
C07C 233/38
C07C 231/14

US Classification:

208289, 564138, 564204, 564192, 196 46

Abstract:

Methods and systems for reducing fouling, including particulate-induced fouling, in a hydrocarbon refining process including the steps of providing a crude hydrocarbon for a refining process and adding an antifouling agent containing a polymer base unit and a polyamine group to the crude hydrocarbon are provided. The antifouling agent can be obtained by converting a vinyl terminated polymer, such as polypropylene or poly(ethylene-co-propylene), to a terminal acyl containing functional group, followed by reacting the terminal acyl containing functional group with a polyamine compound.

US Patent:

61439312, Nov 7, 2000

Filed:

Apr 16, 1998

Appl. No.:

9/061752

Inventors:

Carmen M. Baldino - Lexington MA
David L. Coffen - Cambridge MA
Stewart D. Chipman - Reading MA
Hong Cheng - Brighton MA

Assignee:

ArQule, Inc. - Medford MA

International Classification:

C07C23300

US Classification:

564123

Abstract:

The invention is based on new methods for making and using compounds and arrays of novel. alpha. -ketoamides, and the arrays and compounds made by these methods. These novel compounds are potential inhibitors of proteolytic enzymes, particularly cysteine proteases such as cruzain. Application of the new methods has led to the identification of a number of new inhibitors, from amongst an array of about 38,000. alpha. -ketoamide derivatives, having specific activity against three cysteine proteases: cruzain, papain, and cathepsin B. These compounds and other compounds identified by the methods described herein can be useful, for example, in developing pharmaceutic agents for the treatment of diseases (e. g. , Chagas' disease) associated with these proteases. Although the disclosed compounds have specific activity for cruzain, papain, cathepsin B, the methods described herein can also be used to identify inhibitors of other proteases.

US Patent:

20220415175, Dec 29, 2022

Filed:

Nov 22, 2019

Appl. No.:

17/778283

Inventors:

- San Diego CA, US
Hong CHENG - Basking Ridge NJ, US
Lan YU - Beijing, CN
Gene Wesley MARSH - San Diego CA, US

International Classification:

G08G 1/16
G08G 1/0967

Abstract:

A user equipment (UE) in a vehicle, or a road side unit, may broadcast an inter-vehicle message for a driving maneuver to be executed by the vehicle. The inter-vehicle message may be a coordinated driving maneuver request requiring acceptance from another vehicle or an informational message for the intended driving maneuver. The inter-vehicle message includes a temporal execution window defining a range of time during which the driving maneuver will be initiated. A temporal window defining a range of time during which the driving maneuver will be completed may also be included. A spatial window defining a range of distance for a start and/or stop location for the driving maneuver may also be completed. The vehicle may execute the driving maneuver within the temporal execution window, e.g., if a driving maneuver response is received before the expiration of the temporal execution window, and will otherwise cancel the driving maneuver.

US Patent:

20220416881, Dec 29, 2022

Filed:

Aug 30, 2022

Appl. No.:

17/823498

Inventors:

- San Diego CA, US
Hong CHENG - Basking Ridge NJ, US
Peng CHENG - Beijing, CN

International Classification:

H04B 7/185
H04W 76/11

Abstract:

Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a network entity may receive, from a relay node via a radio access link, information indicating a link layer identifier of the relay node associated with a relay service, wherein the relay node is associated with a radio access identifier. The network entity may configure a relay service with the relay node and a remote node using a mapping between the radio access identifier and the link layer identifier. Numerous other aspects are described.

US Patent:

20220381872, Dec 1, 2022

Filed:

May 25, 2021

Appl. No.:

17/330225

Inventors:

- San Diego CA, US
Hong Cheng - Basking Ridge NJ, US
Kapil Gulati - Belle Mead NJ, US

International Classification:

G01S 5/02
H04W 4/02
H04W 72/04
H04W 4/06
H04L 5/00

Abstract:

Methods, systems, and devices for wireless communication are described. An initiator user equipment (UE) may broadcast, via a sidelink connection to a set of target UEs, a group sidelink communication request that includes a sidelink ranging service identifier. The group sidelink communication request may further include a broadcast identifier or a groupcast identifier. The initiator UE may establish, via the sidelink connection, a set of unicast sidelink sessions with the set of target UEs. some examples, the initiator UE may transmit, via the sidelink connection, a set of position reference signal requests via the set of unicast sidelink sessions to initiate a set of sidelink ranging sessions. The initiator UE may then receive, via the sidelink connection, a set of position reference signal responses from the set of target UEs during each of the plurality of sidelink ranging sessions.