Hong Yudong Z Fan

US Patent:

8030300, Oct 4, 2011

Filed:

Jun 9, 2004

Appl. No.:

10/558607

Inventors:

Alan P. Kozikowski - Chicago IL, US
John L. Musachio - Baltimore MD, US
Kenneth J. Kellar - Bethesda MD, US
Yingxian Xiao - Potomac MD, US
Zhi-Liang Wei - Chicago IL, US
Hong Fan - Timonium MD, US

Assignee:

Georgetown University - Washington DC
The John Hopkins University - Baltimore MD

International Classification:

A61K 31/4427
C07D 401/12

US Classification:

5142102, 5462681

Abstract:

One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. The present invention also relates to the use of a compound of the invention for treating a mammal suffering from Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism or trichtillomania.

US Patent:

20050129610, Jun 16, 2005

Filed:

Jun 24, 2004

Appl. No.:

10/877813

Inventors:

Martin Pomper - Baltimore MD, US
John Musachio - Baltimore MD, US
Hong Fan - Lutherville Timonium MD, US
Robert Dannals - Sparks MD, US
Catherine Foss - Baltimore MD, US
Eifion Phillips - Wilmington DE, US
John Gordon - Wilmington DE, US
Dennis McCarthy - Wilmington DE, US
Richard Keith - Wilmington DE, US
Mark Smith - Wilmington DE, US
Richard Heys - Wilmington DE, US
Peter Dorff - Wilmington DE, US

International Classification:

A61K051/00
A61K031/4747
C07D491/14
C07F005/00

US Classification:

424001110, 514278000, 534011000, 546018000

Abstract:

The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the a7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express a7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.

US Patent:

20100034741, Feb 11, 2010

Filed:

Jan 26, 2009

Appl. No.:

12/321951

Inventors:

Martin G. Pomper - Baltimore MD, US
John L. Musachio - Baltimore MD, US
Hong Fan - Lutherville Timonium MD, US
Robert F. Dannals - Sparks MD, US
Catherine Foss - Baltimore MD, US
Eifion Phillips - Wilmington DE, US
John Gordon - Wilmington DE, US
Dennis McCarthy - Wilmington DE, US
Richard Keith - Wilmington DE, US
Mark Smith - Wilmington DE, US
Richard Heys - Wilmington DE, US
Peter N. Dorff - Wilmington DE, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C07D 453/02
C07D 453/00
A61K 51/04
G01N 33/53

US Classification:

424 189, 546133, 546 83, 424 181, 424 185, 435 72

Abstract:

The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the α7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express α7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.

US Patent:

20120064005, Mar 15, 2012

Filed:

May 26, 2010

Appl. No.:

13/320816

Inventors:

Christopher Cox - Harleysville PA, US
Broc A. Flores - Ardmore PA, US
Eric Hostetler - Collegeville PA, US
Hong Fan - Lansdale PA, US

International Classification:

A61K 51/04
C07D 403/14
G01T 1/20
C07D 403/06

US Classification:

424 181, 544284, 250362

Abstract:

The present invention is directed to radiolabeled pyrimidinone compounds of general structural formula I which are useful as radiotracers for quantitative imaging of PDE10 in mammals.

US Patent:

20190177275, Jun 13, 2019

Filed:

Jun 9, 2017

Appl. No.:

16/308128

Inventors:

- Baltimore MD, US
Daniel P. Holt - Severna Park MD, US
Ying Chen - Lutherville-Timonium MD, US
Ronnie C. Mease - Fairfax VA, US
Hong Fan - Timonium MD, US
Martin G. Pomper - Baltimore MD, US
Robert F. Dannals - Sparks MD, US

International Classification:

C07D 213/42
A61P 35/00
A61K 51/04
C07B 59/00

Abstract:

Methods, and related compositions, for the improved synthesis of [F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [F]DCFPyL so produced.