Howard A Goodman

US Patent:

6355411, Mar 12, 2002

Filed:

Nov 25, 1998

Appl. No.:

09/199637

Inventors:

Frederick Ausubel - Newton MA
Howard M. Goodman - Newton MA
Laurence G. Rahme - Brookline MA
Man-Wah Tan - Somerville MA
Hui Cao - Malden MA
Eliana Drenkard - Cambridge MA
John Tsongalis - Southbridge MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12Q 100

US Classification:

435 4, 530350

Abstract:

Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e. g. , DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.

US Patent:

49753746, Dec 4, 1990

Filed:

Feb 4, 1987

Appl. No.:

7/010612

Inventors:

Howard Goodman - Newton MA
Shiladitya DasSarma - Amherst MA
Edmund Tischer - Palo Alto CA
Theresa K. Peterman - Cambridge MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12N 1500
C12N 900
C12N 120
C07H 1512

US Classification:

4351723

Abstract:

The invention relates to a mutant glutamine synthetase (GS) enzyme which is resistant to inhibition by herbicidal GS inhibitors, such as phosphinothricin (PPT), genetic sequences coding therefor, plants cells and prokaryotes transformed with the genetic sequences, and herbicidal GS inhibitor-resistant plant cells and plants.

US Patent:

60180978, Jan 25, 2000

Filed:

Apr 11, 1995

Appl. No.:

8/419850

Inventors:

Richard Selden - Camb. MA
Howard Goodman - Newton MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A01K 6700
A01K 67033
C12N 1500
G01N 3300

US Classification:

800 18

Abstract:

A process for producing a transgenic mouse which contains and expresses the human insulin hormone gene. The insulin gene is expressed only in the pancreas of the transgenic mouse and is regulated by glucose, glucagon, or other insulin affectors in a manner which is indistinguishable from that of normal mice. Progeny of the trangenic mice inherit the human insulin gene in a Mendelian manner, with approximately 50% of the mice of each litter expressing the human insulin gene. The weights of the transgenic mice, growth rate, feeding behavior, reproductive capability, and longevity appear indistinguishable from normal mice. The mice are useful for studies of pharmacokinetics of insulin expression and for investigations of possible drug interactions with glucose homeostasis.

US Patent:

51457776, Sep 8, 1992

Filed:

May 9, 1991

Appl. No.:

7/700116

Inventors:

Howard M. Goodman - Newton Centre MA
Gunter Donn - Hofheim, DE

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12N 504
C12N 1500
A01H 400
A01H 106

US Classification:

4351723

Abstract:

A plant cell which is resistant to a herbicidal glutamine synthetase inhibitor, wherein the resistance is caused by levels of GS activity which, when present in an otherwise herbicidal GS inhibitor sensitive plant cell, render the cell substantially resistant to the herbicidal GS-inhibitor.

US Patent:

59089717, Jun 1, 1999

Filed:

Jun 5, 1995

Appl. No.:

8/463418

Inventors:

Dominique Van Der Straeten - Gent, BE
Howard Goodman - Newton Center MA
Marc Van Montagu - Brussels, BE

Assignee:

The General Hospital Corporation - Boston MA
Rijksuniversiteit - Gent

International Classification:

A01H 500
A01H 510
C12N 504
C12N 1582

US Classification:

800205

Abstract:

Disclosed is substantially pure DNA encoding a crucifer ACC synthase polypeptide; a promoter functional in immature plant tissues which is capable of ethylene induction; and methods of using such promoters to express recombinant proteins or RNA and to regulate ethylene-inducible events of a plant, e. g. , fruit ripening or senescence, especially during early stages of plant development.

US Patent:

50988387, Mar 24, 1992

Filed:

Jul 24, 1990

Appl. No.:

7/556434

Inventors:

Howard Goodman - Newton MA
Shiladitya DasSarma - Amherst MA
Edmund Tischer - Palo Alto CA
Theresa K. Peterman - Cambridge MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12N 900
C12N 1529
C12N 1570
C12N 1584

US Classification:

435183

Abstract:

The invention relates to a mutant glutamine synthetase (GS) enzyme which is resistant to inhibition by herbicidal GS inhibitors, such as phosphinothricin (PPT), genetic sequences coding therefor, plants cells and prokaryotes transformed with the genetic sequences, and herbicidal GS inhibitor-resistant plant cells and plants.