Howard L Stern

US Patent:

6860428, Mar 1, 2005

Filed:

Sep 11, 1998

Appl. No.:

09/151764

Inventors:

John H. Dowling - Nashua NH, US
Howard Stern - Greenlawn NY, US
Harry R. McKinley - Southampton MA, US
Philip E. McKinley - Westford MA, US
Jason J. Lee - Concord MA, US
Luis Alberto Figarella - Nashua NH, US

Assignee:

Robotic Vision Systems Inc. - Canton MA

International Classification:

G06K007/10
G06K009/22

US Classification:

23546245, 235454, 23546224

Abstract:

A hand-held imager which is capable of reading both linear and two dimensional symbologies, which can perform focusing and illuminating steps quickly and accurately so as to eliminate variation in the position of the imager relative to the code becoming a negative factor, in which can operate in environment where the imager is anywhere from 1. 5 inches to 16 inches from the code. The imager includes an imaging system having a focusing system, an illumination system, and a two-dimensional photodetector which forms an image of the coded symbology. After achieving targeting of the coded symbology, the scanning system adjusts the focus between multiple different focuses, and utilizes a portion of the two-dimensional photodetector to determine the optimum focus. Upon the determination of optimum focus, the focusing system is returned to the focusing configuration established in the initial focusing step, and an image is created using the entire two-dimensional photodetector. Optimum illumination is determined using the same two-dimensional photodetector.

US Patent:

20010053949, Dec 20, 2001

Filed:

Mar 13, 2001

Appl. No.:

09/804811

Inventors:

Curtis Howes - Harvard MA, US
C. Akyuz - Somerville MA, US
Brian Arthur - East Greenwich RI, US
Richard Ouellette - Canton MA, US
Howard Stern - Greenlawn NY, US

Assignee:

Robotic Vision Systems, Inc.

International Classification:

G06F017/00

US Classification:

700/237000, 707/104100, 707/009000, 700/215000, 700/225000, 705/028000

Abstract:

A secure tracking system and method of tracking for articles which are secure and include authentication and verification of users and user devices for data and information access and input. Each article to be tracked is provided with a unique secure indicia applied to the article and through which chronological histories are generated and maintained from creation of each article until at least the time when article is scrapped or otherwise destroyed. The articles can include manufactured components, assemblies, device and equipment for aircraft, automotive, military and other users, as well as jewelry and works of art.

US Patent:

20050092843, May 5, 2005

Filed:

Nov 16, 2004

Appl. No.:

10/988609

Inventors:

John Dowling - Nashua NH, US
Howard Stern - Greenlawn NY, US
Harry McKinley - Southampton MA, US
Philip McKinley - Westford MA, US
Jason Lee - Concord MA, US

International Classification:

G06K007/10
G06K009/22
G03B007/08
G06K005/00
G06K007/14

US Classification:

235472010, 235462450, 235462240

Abstract:

A hand-held imager which is capable of reading both linear and two dimensional symbologies, which can perform focusing and illuminating steps quickly and accurately so as to eliminate variation in the position of the imager relative to the code becoming a negative factor, in which can operate in an environment where the imager is anywhere from 1.5 inches to 16 inches from the code. The imager includes an imaging system having a focusing system, an illumination system, and a two-dimensional photodetector which forms an image of the coded symbology. After achieving targeting of the coded symbology, the scanning system adjusts the focus between multiple different focuses, and utilizes a portion of the two-dimensional photodetector to determine the optimum focus. Upon the determination of optimum focus, the focusing system is returned to the focusing configuration established in the initial focusing step, and an image is created using the entire two-dimensional photodetector. Optimum illumination is determined using the same two-dimensional photodetector.

US Patent:

20050155087, Jul 14, 2005

Filed:

Dec 17, 2002

Appl. No.:

10/499234

Inventors:

Leonard Zon - Wellesley MA, US
Howard Stern - Newton MA, US
Ryan Murphey - Brookline MA, US

International Classification:

A01K067/027
A61K049/00

US Classification:

800003000, 800020000

Abstract:

The present invention is directed to a novel, target-blind approach to drug discovery. The concept is to model human phenotypes in a teleost, such as a zebrafish, and then screen compounds, e.g., small molecules, for their ability to alter the phenotype. Because the screen is performed with a whole vertebrate organism and uses a phenotype as the output, the need to first identify target genes is eliminated. This approach is powerful because a single screen can theoretically detect drugs affecting any target relevant to the phenotype being observed, even if those targets are not yet characterized.

US Patent:

20100298156, Nov 25, 2010

Filed:

Jun 4, 2008

Appl. No.:

12/599380

Inventors:

Si Tuen Lee-Hoeflich - Millbrae CA, US
Howard Stern - San carlos CA, US

International Classification:

C40B 30/04
C40B 40/08

US Classification:

506 9, 506 17

Abstract:

The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.

US Patent:

20110151454, Jun 23, 2011

Filed:

Aug 12, 2010

Appl. No.:

12/806419

Inventors:

Si Tuen Lee-Hoeflich - Millbrae CA, US
Howard Stern - San Carlos CA, US

International Classification:

C12Q 1/68
G01N 33/53
C40B 40/06
C12Q 1/48
C12Q 1/42
G06F 19/00

US Classification:

435 611, 435 721, 435 618, 506 16, 435 15, 435 21, 702 19

Abstract:

The present invention concerns markers of resistance of HER2 expressing tumors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.

US Patent:

60988878, Aug 8, 2000

Filed:

Sep 11, 1998

Appl. No.:

9/152229

Inventors:

Luis A Figarella - Nashua NH
David A. Imrie - Woburn MA
Harry McKinley - Southampton MA
Howard Stern - Greenlawn NY
Jon E. Van Tassell - Winthrop MA

Assignee:

Robotic Vision Systems, Inc. - Canton MA

International Classification:

B06N 0710

US Classification:

23547201

Abstract:

A hand held, omnidirectional symbology or bar code reader for imaging linear and two dimensional (matrix, maxi-code) bar codes over relatively long working distances. The reader includes an imaging system including a focusing objective taking lens and a two-dimensional photodetector that operate to form an image of a bar code in X and Y directions simultaneously and generate an electrical signal representative of the code for subsequent downstream processing which extracts information embedded in a bar code. Focusing is achieved via a rotating disk that carries a plurality of optical shims for different focus zones. A through-the-lens (TTL) targeting system is provided to visually assist the user in positioning the reader for a variety of code modalities to assure that a bar code will be captured within the field of view and be sharply imaged on the photodetector when the lens is focused. Two different forms of artificial illumination are provided to accommodate nearby codes that may be either specular or partially diffuse and more distant codes where the reflection characteristics have less impact on code contrast. Elements of the photodetector are used to assess available light levels and activate the artificial illumination system when ambient light levels are low.

US Patent:

60668571, May 23, 2000

Filed:

Sep 11, 1998

Appl. No.:

9/151496

Inventors:

Stephen D. Fantone - Lynnfield MA
Luis A. Figarella - Nashua NH
David A Imrie - Woburn MA
Harry McKinley - Southampton MA
William T. Plummer - Concord MA
Howard Stern - Greenlawn NY
Jon E. Van Tassell - Winthrop MA

Assignee:

Robotic Vision Systems, Inc. - Canton MA

International Classification:

G02B 704
G06K 710

US Classification:

250566

Abstract:

A focusable imaging system particularly suitable for use in acquiring digital images for subsequent processing such as in a hand held, omnidirectional symbology or bar code reader by which linear and two dimensional (matrix, maxi-code) bar codes may be imaged over relatively long working distances. The imaging system includes an focusing objective taking lens and a two-dimensional photodetector that operate to form an image of an object such as a bar code in X and Y directions simultaneously and generate an electrical signal representative of the object or code for subsequent downstream processing by which information embedded in the object or bar code may be extracted. Focusing is achieved via a rotating disk that carries a plurality of optical shims or other light controlling surfaces to provide for different focus zones. A through-the-lens (TTL) targeting system is provided to visually assist the user in positioning the reader for a variety of code modalities to assure that a bar code or the like will be captured within the field of view and be sharply imaged on the photodetector when the lens is focused. Two different forms of artificial illumination are provided to accommodate nearby objects or codes that may be either specular or partially diffuse and more distant objects or codes where the reflection characteristics have less impact on image contrast.