Huasheng Y Lu

US Patent:

20080045463, Feb 21, 2008

Filed:

Oct 25, 2005

Appl. No.:

11/666229

Inventors:

Ajay Verma - Harleysville PA, US
Huasheng Lu - Boyds MD, US

International Classification:

A61K 31/195
A61K 31/34
A61K 31/415
A61K 38/00
A61P 43/00

US Classification:

514018000, 514399000, 514474000, 514562000

Abstract:

The present invention relates to the elucidation of specific molecular features of endogenous amino acids and their derivatives for inhibiting hypoxia-inducible gene expression by preventing inactivation of hypoxia-inducible factor hydroxylating enzymes. This invention encompasses agents that can be used to reduce tissue vascularization, cancer cell survival, and to treat obesity.

US Patent:

20070173545, Jul 26, 2007

Filed:

Nov 8, 2004

Appl. No.:

10/578438

Inventors:

Ajay Verma - Harleysville PA, US
Huasheng Lu - Boyds MD, US
Robert Forbes - Princeton NJ, US
Clifton Dalgard - San Francisco CA, US
Ahmed Mohyeldin - Washington DC, US
Ronald Zenk - Eden Prairie MN, US

International Classification:

A61K 31/19
A61K 31/21
C12N 15/01

US Classification:

514506000, 435441000, 514557000

Abstract:

The present invention relates to the elucidation of specific molecular features of endogenous 2-oxoacid molecules and their derivatives for activating hypoxia-inducible gene expression by inactivating hypoxia-inducible factor hydroxylating enzymes. This invention identifies agents that can be used to induce tissue vascularization, treat anemias, induce tolearance to stroke and heart attacks, improve tissue healing and improve organ transplantation.