Hugo Caldas

US Patent:

20090239937, Sep 24, 2009

Filed:

Aug 26, 2005

Appl. No.:

11/661224

Inventors:

Hugo Caldas - Winston-Salem NC, US
Rachel A. Altura - Sharon MA, US

International Classification:

A61K 31/7088
C07H 21/04
C07H 1/00
A61P 35/00

US Classification:

514 44 R, 536 231, 536124

Abstract:

The invention provides materials and methods related to the use of recombinant nucleic acid molecules containing an expression control element of an inhibitor of apoptosis protein (IAP) gene operatively linked to a coding region for an active cytotoxic/cytolytic agent. The recombinant molecules are used in methods to treat a variety of diseases and disorders, including a wide range of cancers.

US Patent:

20060276423, Dec 7, 2006

Filed:

Apr 18, 2006

Appl. No.:

11/406740

Inventors:

Rachel Altura - Bexley OH, US
Hugo Caldas - Columbus OH, US
Michael Holloway - Bexley OH, US

International Classification:

A61K 48/00
A61K 31/337
C12Q 1/68
C07H 21/02

US Classification:

514044000, 514449000, 435006000, 536023200

Abstract:

The present invention is directed to compositions and methods for inhibiting the expression of survivin in cells expressing survivin. The invention is also directed to methods of treating conditions associated with elevated survivin, such as hyperproliferative disorders. More particularly, the invention is directed to inhibition of survivin expression using short interfering RNAs (si-RNAs) or through administration of DNA sequences yielding the expression of short hairpin RNAs (sh-RNAs).