Hui L Ding

US Patent:

8309614, Nov 13, 2012

Filed:

Apr 10, 2009

Appl. No.:

12/935110

Inventors:

Hui Ding - Los Angeles CA, US
Julia Y. Ljubimova - Studio City CA, US
Eggehard Holler - Los Angeles CA, US
Keith L. Black - Los Angeles CA, US

Assignee:

Cedars-Sinai Medical Center - Los Angeles CA

International Classification:

A61K 47/14
C07H 21/02

US Classification:

514772, 536 245, 977704, 977906

Abstract:

The invention relates to the use of Polycefin-LLL nanoconjugate as a means of cytoplasmic delivery of drugs. In one embodiment, the present invention provides a drug delivery molecule, comprising a polymerized carboxylic acid molecular scaffold covalently linked to L-leucylleucylleucine. In another embodiment, the Polycefin-LLL includes drug antisense morpholino oligos, targeting antibodies, and a pH-sensitive endosome escape unit. In addition, the drug could be siRNA, microRNA, and aptamer.

US Patent:

20200202244, Jun 25, 2020

Filed:

Sep 24, 2019

Appl. No.:

16/580168

Inventors:

- Canonsburg PA, US
Hui Ding - Los Altos CA, US
Norman Chang - Fremont CA, US

International Classification:

G06N 5/04
G06N 20/00
G06F 17/50

Abstract:

Machine assisted systems and methods for detecting unreliable circuit patterns are described. These systems and methods can use a machine learning classifier, that has been trained to recognize such circuit patterns, to detect the unreliable circuit patterns without requiring computationally expensive simulations of a circuit netlist which can be over a million devices (e.g. over a million FETs). The classifier, once trained, can recognize unreliable circuit patterns quickly and can be updated over time as new unreliable circuit patterns are discovered from simulations or other sources.

US Patent:

20200155593, May 21, 2020

Filed:

Jan 27, 2020

Appl. No.:

16/773769

Inventors:

- LOS ANGELES CA, US
Hui Ding - Los Angeles CA, US
Eggehard Holler - Los Angeles CA, US
Keith L. Black - Los Angeles CA, US
Julia Y. Ljubimova - Studio City CA, US

International Classification:

A61K 31/713
C07K 16/32
C07K 16/28

Abstract:

Nanobiopolymeric conjugates based on biodegradable, non-toxic and non-immunogenic poly (β-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are provided. Methods for treating a cancer in subject with nanobiopolymeric conjugates are described.

US Patent:

20190182513, Jun 13, 2019

Filed:

Feb 15, 2019

Appl. No.:

16/277482

Inventors:

- Menlo Park CA, US
Hui Ding - Sunnyvale CA, US
Ian McIntyre Silber - San Francisco CA, US

International Classification:

H04N 21/2187
H04H 60/46
H04H 60/45
G06Q 30/00
H04N 21/4788
H04N 21/24
H04N 21/431
H04N 21/8545
H04N 21/234
H04N 21/414

Abstract:

The present disclosure is directed toward systems and methods for providing a start trigger for a live video broadcast. In particular, in some embodiments the systems and methods described herein provide a live video stream received from a broadcaster client device to one or more viewer client devices. Additionally, the systems and methods described herein determine whether an audience satisfies a triggering event to provide the video stream to an audience of viewers. The systems and methods provide content for a wait screen in response to determining that the audience does not satisfy the triggering event, and provide the video stream in a live broadcast in response to determining that the audience does satisfy the triggering event.

US Patent:

20190060479, Feb 28, 2019

Filed:

Mar 3, 2017

Appl. No.:

16/081584

Inventors:

- Los Angeles CA, US
Keith L. BLACK - Los Angeles CA, US
Eggehard HOLLER - Los Angeles CA, US
Alexander LJUBIMOV - Studio City CA, US
Hui DING - Los Angeles CA, US

Assignee:

CEDARS-SINAI MEDICAL CENTER - Los Angeles CA

International Classification:

A61K 47/68
A61K 47/59
A61K 47/18
A61K 47/10
A61K 45/06
A61P 35/00

Abstract:

Nanoimmunoconjugates including a polymalic acid-based molecular scaffold, targeting ligands, anti-tumor immune response stimulators and anti-cancer agents are provided. Methods for treating cancer in a subject by administering the nanoimmunoconjugates that provide both systemic and local immune responses and synergistic anticancer effect are described.

US Patent:

20180310031, Oct 25, 2018

Filed:

Apr 24, 2017

Appl. No.:

15/495013

Inventors:

- Menlo Park CA, US
Hui Ding - Sunnyvale CA, US
Ian McIntyre Silber - San Francisco CA, US

International Classification:

H04N 21/2187
H04N 21/24
H04N 21/234
H04N 21/8545
H04N 21/431
H04N 21/414
H04N 21/4788

Abstract:

The present disclosure is directed toward systems and methods for providing a start trigger for a live video broadcast. In particular, in some embodiments the systems and methods described herein provide a live video stream received from a broadcaster client device to one or more viewer client devices. Additionally, the systems and methods described herein determine whether an audience satisfies a triggering event to provide the video stream to an audience of viewers. The systems and methods provide content for a wait screen in response to determining that the audience does not satisfy the triggering event, and provide the video stream in a live broadcast in response to determining that the audience does satisfy the triggering event.

US Patent:

20180034653, Feb 1, 2018

Filed:

Sep 27, 2017

Appl. No.:

15/717774

Inventors:

- Menlo Park CA, US
Thomas Frederick Dimson - Stanford CA, US
Kevin York Systrom - San Francisco CA, US
Hui Ding - Sunnyvale CA, US
Michel Krieger - San Francisco CA, US

International Classification:

H04L 12/18
G06F 17/30
H04L 12/58
H04L 29/06
H04L 29/08
H04W 4/20
H04W 4/06

Abstract:

A social networking system user identifies one or more social networking system users authorized to present content items to the user via the social networking system (“authorized users”). When an additional user requests presentation of a content item to the user, the social networking system determines if the additional user is an authorized user. If the additional user is an authorized user, the content item is presented to the user. However, if the additional user is not an authorized user, the social networking system identifies the additional user to the user along with a request to identify the additional user as an authorized user. If the user identifies the additional user as an authorized user in response to the request, the content item is presented to the user.

US Patent:

20180026804, Jan 25, 2018

Filed:

Sep 22, 2017

Appl. No.:

15/713388

Inventors:

- Menlo Park CA, US
Michel Krieger - San Francisco CA, US
Christopher Cunningham - Sunnyvale CA, US
Hui Ding - Sunnyvale CA, US

International Classification:

H04L 12/18
G06F 17/30
H04L 12/58
H04L 29/06
H04L 29/08
H04W 4/20
H04W 4/06

Abstract:

A social networking system user identifies one or more social networking system users authorized to present content items to the user via the social networking system (“authorized users”). When an additional user requests presentation of a content item to the user, the social networking system determines if the additional user is an authorized user. If the additional user is an authorized user, the content item is presented to the user. However, if the additional user is not an authorized user, the social networking system identifies the additional user to the user along with a request to identify the additional user as an authorized user. If the user identifies the additional user as an authorized user in response to the request, the content item is presented to the user.