Hui Ying Li

US Patent:

20220195407, Jun 23, 2022

Filed:

May 7, 2020

Appl. No.:

17/609244

Inventors:

- Durham NC, US
Hui Li - Apex NC, US

Assignee:

Precision BioSciences, Inc. - Durham NC

International Classification:

C12N 9/22
C12N 15/10
C12N 15/86

Abstract:

The invention provides engineered meganucleases, derived from I-Crel, which have substitutions at particular positions that increase the activity of the nucleases for recognition sequences containing certain center sequences. The invention also provides methods of cleaving double-stranded DNA using such engineered meganucleases. The invention further provides methods for improving the activity of engineered meganucleases for recognition sequences containing certain center sequences.

US Patent:

20210113616, Apr 22, 2021

Filed:

Apr 11, 2019

Appl. No.:

17/046761

Inventors:

- Durham NC, US
Janel Lape - Wake Forest NC, US
Hui Li - Apex NC, US
Jochen Genschel - Raleigh NC, US

Assignee:

Precision BioSciences, Inc. - Durham NC

International Classification:

A61K 35/17
C12N 9/22
C12N 15/86
C07K 14/725

Abstract:

The present invention encompasses engineered nucleases which recognize and cleave a recognition sequence within the first exon of the human T cell receptor (TCR) alpha constant region gene. The engineered meganucleases can exhibit at least one optimized characteristic, such as enhanced (i.e., increased) specificity or efficiency of cleavage, when compared to the first-generation meganuclease TRC 1-2x.87EE. The present invention also encompasses methods of using such engineered nucleases to make genetically-modified cells, and the use of such cells in a pharmaceutical composition and in methods for treating diseases, such as cancer.

US Patent:

20200071935, Mar 5, 2020

Filed:

Nov 6, 2019

Appl. No.:

16/676252

Inventors:

- Dublin, IE
Brian McQuerrey - Rancho Cucamonga CA, US
Hui Li - Fontana CA, US
Noel A. Dones - Rancho Cucamonga CA, US

International Classification:

E04F 13/08
E04F 13/00
E04B 1/66
E04C 2/26
E04B 1/74

Abstract:

A building system including a first water resistant layer secured to a building substrate, first and second building articles secured to the first water resistant layer and the building substrate such that sides of the building articles are positioned adjacent one another along an abutment line, and a second water resistant layer secured to portions of the first and second building articles along the abutment line to prevent liquid from traveling past the sides of the building articles to the first water resistant layer and the building substrate. In some embodiments, the building articles are fiber cement building articles. In some embodiments, the building articles include a plurality of integrally formed drainage channels and a plurality of spacer sections disposed between the drainage channels, each of the plurality of drainage channels defining an air gap comprising a liquid flow path.

US Patent:

20190338263, Nov 7, 2019

Filed:

Apr 11, 2019

Appl. No.:

16/381668

Inventors:

- Durham NC, US
Janel Lape - Wake Forest NC, US
Victor Bartsevich - Durham NC, US
Hui Li - Apex NC, US

Assignee:

Precision BioSciences, Inc. - Durham NC

International Classification:

C12N 9/22
C12N 15/86
A61K 9/16
A61K 47/69

Abstract:

The present invention encompasses engineered nucleases which recognize and cleave a recognition sequence within a Hepatitis B virus (HBV) genome. The engineered meganucleases can exhibit at least one optimized characteristic, such as enhanced specificity and/or efficiency of indel formation, when compared to the first-generation meganuclease HBV 11-12x.26. Further, the invention encompasses pharmaceutical compositions comprising engineered meganuclease proteins, nucleic acids encoding engineered meganucleases, and the use of such compositions for treating HBV infections or hepatocellular carcinoma.

US Patent:

20180328044, Nov 15, 2018

Filed:

Dec 22, 2016

Appl. No.:

15/773059

Inventors:

- Dublin 2, IE
Brian McQuerrey - Rancho Cucamonga CA, US
Hui Li - Fontana CA, US

International Classification:

E04F 13/08
E04F 13/00

Abstract:

A wall cladding panel comprising a substantially planar front face, a rear face comprising a plurality of drainage channels and a plurality of spacer sections disposed between the drainage channels, and an edge member disposed contiguously between the front face and the rear face. The wall cladding panel is locally thinner at the drainage channels than at the spacer sections. Each drainage channel is configured to form a liquid flow path and/or an air gap when a substantially planar building surface is placed adjacent to the rear face. A plurality of wall cladding panels with drainage channels may be arranged in series to cover at least a portion of a building.