Hui M Li

US Patent:

6380189, Apr 30, 2002

Filed:

Feb 11, 2000

Appl. No.:

09/502038

Inventors:

Norman Abood - Morton Grove IL
Daniel L. Flynn - Mundelein IL
Daniel P. Becker - Glenview IL
Brian M. Bax - St. Lcharles IL
Hui Li - Skokie IL
Roger A. Nosal - Buffalo Grove IL
Lori A. Schretzman - Gurnee IL
Clara I. Villamil - Glenview IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A61K 31536

US Classification:

5142305, 544 92

Abstract:

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R are as defined herein, or a pharmaceutically-acceptable salt thereof.

US Patent:

6638952, Oct 28, 2003

Filed:

Dec 23, 1999

Appl. No.:

09/254530

Inventors:

Hui Li - Vernon Hills IL
Daniel P. Becker - Glenview IL
Clara I. Villamil - Glenview IL
Terri L. Boehm - Ballwin MO
Daniel P. Getman - Chesterfield MO
Joseph J. McDonald - Ballwin MO
Gary A. DeCrescenzo - St. Charles MO

Assignee:

Pharmacia Corporation - Skokie IL

International Classification:

A61K 31445

US Classification:

514330, 546221

Abstract:

An aromatic sulfonyl alpha-cycloamino hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-cycloamino hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

US Patent:

6683077, Jan 27, 2004

Filed:

Jan 4, 2002

Appl. No.:

10/035433

Inventors:

Norman Abood - Morton Grove IL
Daniel L. Flynn - Mundelein IL
Daniel P. Becker - Glenview IL
Brian M. Bax - Irvine CA
Hui Li - Vernon Hills IL
Roger A. Nosal - Buffalo Grove IL
Lori A. Schretzman - Gurnee IL
Clara I. Villamil - Glenview IL

Assignee:

G.D. Searle Co. - St. Louis MO

International Classification:

A61K 31535

US Classification:

5142305, 544 92

Abstract:

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R are as defined herein, or a pharmaceutically-acceptable salt thereof.

US Patent:

6750233, Jun 15, 2004

Filed:

Sep 17, 2001

Appl. No.:

09/954451

Inventors:

Thomas E. Barta - Evanston IL
Daniel P. Becker - Glenview IL
Louis J. Bedell - Mt. Prospect IL
Terri L. Boehm - Ballwin MO
Jeffery N. Carroll - Collinsville IL
Gary A. DeCrescenzo - St. Charles MO
Yvette M. Fobian - Labadie MO
John N. Freskos - Clayton MO
Daniel P. Getman - Chesterfield MO
Joseph J. McDonald - Ballwin MO
Susan L. Hockerman - Chicago IL
Susan C. Howard - Fenton MO
Steve A. Kolodziej - Ballwin MO
Hui Li - Vernon Hills IL
Deborah A. Mischke - Defiance MO
Joseph G. Rico - Ballwin MO
Nathan W. Stehle - Ballwin MO
Michael B. Tollefson - OFallon MO
William F. Vernier - St. Louis MO
Clara I. Villamil - Glenview IL

Assignee:

Pharmacia Corporation - St. Louis MI

International Classification:

A61K 31382

US Classification:

514336, 514252, 514342, 514383, 514432, 544374, 5462801, 5482658, 549 28

Abstract:

A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor.

US Patent:

7848558, Dec 7, 2010

Filed:

Feb 13, 2004

Appl. No.:

10/777041

Inventors:

Maryellen L. Giger - Elmhurst IL, US
Hui Li - Chicago IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

G06K 9/00

US Classification:

382132, 382155, 382129

Abstract:

A computerized method, system and computer program for the computerized fractal-based analysis of a structure as presented in a pattern on a medical image. Image data is generated from the medical image and a region of interest is selected. The image data is digitized and analyzed to reveal fractal-based computer-generated features of a texture of the image data. Then a qualifier is applied to the computer-generated features to obtain fractal characteristics of the image data. A multi-fractal nature is observed for the texture of the region of interest. A marker for assessing a risk of a disease is yielded based on the multi-fractal nature of the texture.

US Patent:

20040097487, May 20, 2004

Filed:

Oct 27, 2003

Appl. No.:

10/695278

Inventors:

Hui Li - Vernon Hills IL, US
Daniel Becker - Glenview IL, US
Clara Villamil - Glenview IL, US
Terri Boehm - Ballwin MO, US
Daniel Getman - Chesterfield MO, US
Joseph McDonald - Ballwin MO, US
Gary DeCrescenzo - St. Charles MO, US

Assignee:

G.D. Searle & Co. - Chicago IL

International Classification:

A61K031/55
A61K031/454
A61K031/4025
A61K031/401

US Classification:

514/217110, 514/326000, 514/423000, 514/422000, 540/607000, 546/207000, 546/225000, 548/537000, 548/517000

Abstract:

An aromatic sulfonyl alpha-cycloamino hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-cycloamino hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

US Patent:

20050032793, Feb 10, 2005

Filed:

Dec 8, 2003

Appl. No.:

10/728946

Inventors:

Norman Abood - Morton Grove IL, US
Daniel Flynn - Mundelein IL, US
Daniel Becker - Glenview IL, US
Brian Bax - Irvine CA, US
Hui Li - Vernon Hills IL, US
Roger Nosal - Buffalo Grove IL, US
Lori Schretzman - Gurnee IL, US
Clara Villamil - Glenview IL, US

Assignee:

G.D. Searle & Co. - Chicago IL

International Classification:

C07D265/12
A61K031/535

US Classification:

514230500, 544092000

Abstract:

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-Rare as defined herein, or a pharmaceutically-acceptable salt thereof.

US Patent:

20060106712, May 18, 2006

Filed:

Oct 31, 2005

Appl. No.:

11/163808

Inventors:

Min Guo - Long Grove IL, US
Hui Li - Long Grove IL, US

International Classification:

G06Q 40/00

US Classification:

705037000

Abstract:

Methods and apparatus are described for facilitating transactions between a plurality of buyers and a plurality of sellers via the Internet. Product information relating to a plurality of products meeting product criteria specified by a group of buyers is presented via the Internet. Buyers place requests for products at desired levels. The mechanism automatically aggregates the buying power and bundles it for sellers to bid on. The present invention provides an easy B2C/B2B mechanism for sellers as well as a mechanism for buyers to benefit from wholesale prices.