Hui H Li

US Patent:

20100332499, Dec 30, 2010

Filed:

Jun 26, 2009

Appl. No.:

12/493097

Inventors:

Yufei Pan - North Brunswick NJ, US
Hui Li - Edison NJ, US
Justin Sarma - New York NY, US
David Soukal - Bothell WA, US
Alessio Signorini - Boulder CO, US
Apostolos Gerasoulis - Edison NJ, US
Tomasz Imielinski - Princeton NJ, US

Assignee:

IAC SEARCH & MEDIA, INC. - New York NY

International Classification:

G06F 17/30

US Classification:

707759, 707769

Abstract:

In a method for a direct answer for search, a search query is received over a network, one or more answer candidate snippets for the search query are received, with an answer candidate snippet having at least a portion of content available over the network for an answer candidate, one or more answer entities are determined within a selected answer candidate snippet, a frequency of the one or more answer entities found within the one or more answer candidate snippets for the search query is determined, a confidence score is adjusted for the selected answer candidate in accordance with the frequency of the one or more answer entities found within the one or more answer candidate snippets, and at least one answer candidate snippet is sent for a response to the search query.

US Patent:

20220274103, Sep 1, 2022

Filed:

May 20, 2022

Appl. No.:

17/749720

Inventors:

- University Park PA, US
Tak-Sing WONG - University Park PA, US
Jing WANG - University Park PA, US
Hui LI - University Park PA, US
Yi LU - University Park PA, US
Ying WAN - University Park PA, US

International Classification:

B01L 3/00

Abstract:

A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.

US Patent:

20210322984, Oct 21, 2021

Filed:

Jul 11, 2019

Appl. No.:

17/259136

Inventors:

- University Park PA, US
Hui LI - University Park PA, US

International Classification:

B01L 3/00
C12Q 1/04
C12Q 1/18
C12Q 1/689

Abstract:

Provided are devices and methods for detecting the presence, absence, and/or characteristics of bacteria. A microfluidic device for characterizing bacteria is provided. The device contains one or more bacteria trapping channels, and one or more pneumatic channels in contact with the bacteria trapping channels, wherein the one or more pneumatic channels are configured to reduce the height of the one or more bacteria trapping channels to thereby trap bacteria in the one or more bacteria trapping channels if said bacteria are present in a liquid biological sample that is introduced into the microfluidic device. Also provides is a method for identifying bacteria that may be used with the microfluidic device. The method includes contacting a sample that contains bacteria with a carbon nanotube and microwave energy such that a probe is introduced into the bacteria. The probe is a double strand polynucleotide probe having a first strand that includes a detectable label, and a second strand having a quencher moiety that quenches a signal from the detectable label when the probe is double stranded. The method includes allowing hybridization between the labeled strand with a polynucleotide in the bacteria if bacteria are present, and if bacteria are present, detecting a signal from the labeled strand that is hybridized to a polynucleotide in the bacteria to thereby identify the presence of, and/or the type of bacteria in the sample, and if the bacteria are not present, determining a lack of a signal from the labeled strand.

US Patent:

20210017171, Jan 21, 2021

Filed:

Jun 26, 2020

Appl. No.:

16/914209

Inventors:

- South San Francisco CA, US
Chengguo DONG - Staten Island NY, US
Timothy HOM - Sunnyvale CA, US
Lan JIANG - Foster City CA, US
Katerina LEFTHERIS - San Mateo CA, US
Hui LI - Santa Clara CA, US
Manuel MUNOZ - Vallejo CA, US
Maureen REILLY - Burlingame CA, US
Yajun ZHENG - Foster City CA, US

International Classification:

C07D 471/04
C07D 519/00

Abstract:

The invention relates to compounds of formula (A) and formula (I):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

US Patent:

20200352942, Nov 12, 2020

Filed:

Apr 8, 2020

Appl. No.:

16/843824

Inventors:

- South San Francisco CA, US
Chengguo DONG - Staten Island NY, US
Timothy HOM - Sunnyvale CA, US
Lan JIANG - Foster City CA, US
Katerina LEFTHERIS - San Mateo CA, US
Hui LI - Santa Clara CA, US
Manuel MUNOZ - Vallejo CA, US
Maureen REILLY - Burlingame CA, US
Yajun ZHENG - Foster City CA, US
Martin DECARIS - Oakland CA, US
Scott TURNER - Oakland CA, US

International Classification:

A61K 31/5025
A61K 31/502
A61K 31/4375
A61K 9/00
A61P 11/00

Abstract:

The invention relates to dosage forms for daily administration of compounds of formula (A) and formula (I):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

US Patent:

20190276449, Sep 12, 2019

Filed:

Mar 7, 2019

Appl. No.:

16/296194

Inventors:

- South San Francisco CA, US
Chengguo DONG - Staten Island NY, US
Timothy HOM - Sunnyvale CA, US
Lan JIANG - Foster City CA, US
Katerina LEFTHERIS - San Mateo CA, US
Hui LI - Santa Clara CA, US
Manuel MUNOZ - Vallejo CA, US
Maureen REILLY - Burlingame CA, US
Yajun ZHENG - Foster City CA, US

International Classification:

C07D 471/04
C07D 519/00

Abstract:

The invention relates to compounds of formula (A) and formula (I):or a salt thereof, wherein R, R, R, R, R, R, R, R, R, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

US Patent:

20190126268, May 2, 2019

Filed:

Oct 29, 2018

Appl. No.:

16/174008

Inventors:

- University Park PA, US
Tak-Sing WONG - University Park PA, US
Jing WANG - University Park PA, US
Hui LI - University Park PA, US
Yi LU - University Park PA, US
Ying WAN - University Park PA, US

International Classification:

B01L 3/00

Abstract:

A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.

US Patent:

20190093157, Mar 28, 2019

Filed:

Apr 6, 2017

Appl. No.:

16/091741

Inventors:

- Columbus OH, US
Shaoying Wang - Middlesex NJ, US
Hui Li - San Francisco CA, US

International Classification:

C12Q 1/6869
C12Q 1/6806
C12Q 1/6837

Abstract:

Disclosed herein are RNA nanopores that can be used for single molecule sensing, disease diagnosis, and even protein sequencing.