Hui Sun

US Patent:

20090048196, Feb 19, 2009

Filed:

Jan 18, 2008

Appl. No.:

12/016883

Inventors:

Hui Sun - Culver City CA, US
Riki Kawaguchi - Tarzana CA, US
Dean Bok - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 31/7105
C12Q 1/02
G01N 33/53
A01K 67/027
C12N 5/06
C12Q 1/68

US Classification:

514 44, 435 29, 435 72, 435 6, 435325, 800 13

Abstract:

Provided is a method of diagnosing a condition associated with abnormal uptake of a retinoid comprising determining the amount of STRA6 expressed by a suspect cell and comparing the amount of expressed STRA6 in the suspect cell with the amount of expressed STRA6 in a normal cell. Also provided is a method for treating a condition associated with excessive uptake or insufficient uptake of a retinoid comprising administering to a subject in need thereof an amount of a drug effective for lowering or increasing expression or activity of STRA6 in cells. Also provided is a method of screening for a compound which alters the uptake of a retinoid by a cell comprising exposing the cell to the compound and determining if the expression or activity of STRA6 is altered.

US Patent:

20230098714, Mar 30, 2023

Filed:

Aug 5, 2022

Appl. No.:

17/882009

Inventors:

- New Rochelle NY, US
Hui B. SUN - New Rochelle NY, US

International Classification:

C12N 15/113
A61P 19/04

Abstract:

Provided herein are compositions and methods of use for mimicking miRNA activity. For example, these compositions can be effective in modulating expression of pro-inflammatory mediators, such as NLRP3. The compositions can be useful for treating musculoskeletal or connective tissue repair or degenerative conditions, for example, tendinopathy and tendon injury.

US Patent:

20210322482, Oct 21, 2021

Filed:

Aug 21, 2017

Appl. No.:

16/327402

Inventors:

- Bronx NY, US
Hui B. Sun - Chappaqua NY, US

Assignee:

ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. - Bronx NY

International Classification:

A61K 35/28
C12N 5/077

Abstract:

Microvesicles produced by stem cells grown on a silk scaffold for enhancing stem cell self-renewal/proliferation and promoting tenogenesis in damaged tendons, and their use in tendon wound repair and tendinopathy treatment. Also provided are compositions containing the microvesicles and devices for obtaining them.

US Patent:

20210098074, Apr 1, 2021

Filed:

Sep 27, 2019

Appl. No.:

16/585679

Inventors:

- ARMONK NY, US
- Cambridge MA, US
Tengfei Ma - White Plains NY, US
Zhao Qin - Lynnfield MA, US
Eugene Jungsup Lim - Cambridge MA, US
Francisco Javier Martin-Martinez - Grenada, ES
Hui Sun - Cambridge MA, US
Benedetto Marelli - Lexington MA, US
Markus Jochen Buehler - Boxford MA, US

International Classification:

G16B 5/00
G06N 3/08
G06N 3/04
G16B 15/20
G16B 40/00

Abstract:

A method, computer system, and a computer program product for designing one or more folded structural proteins from at least one raw amino acid sequence is provided. The present invention may include computing one or more character embeddings based on the at least one raw amino acid sequence by utilizing a multi-scale neighborhood-based neural network (MNNN) model. The present invention may then include refining the computed one or more character embeddings with at least one set of sequence neighborhood information. The present invention may further include predicting one or more dihedral angles based on the refined one or more character embeddings.