Hui Ting Sun

US Patent:

20090048196, Feb 19, 2009

Filed:

Jan 18, 2008

Appl. No.:

12/016883

Inventors:

Hui Sun - Culver City CA, US
Riki Kawaguchi - Tarzana CA, US
Dean Bok - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 31/7105
C12Q 1/02
G01N 33/53
A01K 67/027
C12N 5/06
C12Q 1/68

US Classification:

514 44, 435 29, 435 72, 435 6, 435325, 800 13

Abstract:

Provided is a method of diagnosing a condition associated with abnormal uptake of a retinoid comprising determining the amount of STRA6 expressed by a suspect cell and comparing the amount of expressed STRA6 in the suspect cell with the amount of expressed STRA6 in a normal cell. Also provided is a method for treating a condition associated with excessive uptake or insufficient uptake of a retinoid comprising administering to a subject in need thereof an amount of a drug effective for lowering or increasing expression or activity of STRA6 in cells. Also provided is a method of screening for a compound which alters the uptake of a retinoid by a cell comprising exposing the cell to the compound and determining if the expression or activity of STRA6 is altered.