Hui Chin Yang

US Patent:

6525061, Feb 25, 2003

Filed:

Nov 10, 2000

Appl. No.:

09/711795

Inventors:

Ariamala Gopalsamy - Mahwah NJ
Hui Y. Yang - New City NY

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31517

US Classification:

5142663, 514267, 544249, 544287

Abstract:

The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I): having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

US Patent:

6586187, Jul 1, 2003

Filed:

Apr 13, 2000

Appl. No.:

09/548697

Inventors:

Ariamala Gopalsamy - Mahwah NJ
Hui Y. Yang - New City NY

Assignee:

Wyeth - Madison NJ

International Classification:

G01N 3353

US Classification:

435 71, 435 4, 435DIG 22, 435DIG 34, 435DIG 40, 51425212, 51425301, 530333, 530334, 530335, 544295, 544358, 544340, 544400

Abstract:

Compounds of the formula are useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer, diabetic retinopathy, rheumatoid arthritis), restenosis (following balloon angioplasty or stent implantation), inflammation (as in rheumatoid arthritis, psoriasis), bone diseases (osteopenia induced by bone metastases, immobilization and glucocortocoid treatment, periodontal disease, hyperparathyroidism and rheumatoid arthritis), and as antiviral agents. Novel method of making compounds of formula I are also provided.

US Patent:

7129266, Oct 31, 2006

Filed:

Dec 15, 2003

Appl. No.:

10/735953

Inventors:

Haiyin He - Washington Township NJ, US
Hui Yang - Monsey NY, US
Ramunas Bigelis - Congers NY, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 31/4015
C07D 207/18

US Classification:

514423, 548530, 548539, 514424

Abstract:

The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.

US Patent:

7211417, May 1, 2007

Filed:

Apr 28, 2004

Appl. No.:

10/833645

Inventors:

Haiyin He - Mahwah NJ, US
Hui Yu Yang - Tappan NY, US
Scott William Luckman - Ringwood Borough NJ, US
Valerie S. Bernan - New City NY, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 31/496
C12P 17/16
C12N 1/12
C12N 1/20
C07D 401/06

US Classification:

435118, 4352521, 51425302, 544361

Abstract:

This invention relates to a new antibiotic designated P175-A, to production of fermentation of NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic esters and ethers of P175-A.

US Patent:

20020049320, Apr 25, 2002

Filed:

Apr 4, 2001

Appl. No.:

09/825979

Inventors:

Ariamala Gopalsamy - Mahwah NY, US
Hui Yang - New City NY, US

Assignee:

American Cyanamid Company - Madison NJ

International Classification:

C 07D 4 3/02
C07D251/42

US Classification:

544/194000, 544/212000

Abstract:

The present invention relates to substituted 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine compounds of formula (I) having pharmacological activity, to solid phase synthesis methods for their preparation, to combinatorial libraries thereof, utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

US Patent:

20060204426, Sep 14, 2006

Filed:

Nov 16, 2005

Appl. No.:

11/280919

Inventors:

Daniel Akins - Teaneck NJ, US
Hui Yang - Corona NY, US

Assignee:

Research Foundation of the City University of New York - New York NY

International Classification:

C01B 31/02
B32B 27/04

US Classification:

42344500B, 422150000

Abstract:

A method of making carbon nanotubes includes reacting hydrogen and carbon monoxide in a reaction chamber and in the presence of stainless steel. Typically, the carbon nanotubes are formed on the stainless steel. These carbon nanotubes can be removed from the stainless steel and can be used in a variety of applications.