Antonio Jose del Moral Barbosa, Jr. - Middlebury NY, US Joerg Martin Bentzien - White Plains NY, US Steven Richard Brunette - New Milford CT, US Zhidong Chen - New Milford CT, US Derek Cogan - Sandy Hook CT, US Donghong A. Gao - Hopewell Junction NY, US Joshua Courtney Horan - Danbury CT, US Jennifer A. Kowalski - New Milford CT, US Michael David Lawlor - Seymour CT, US Rene Marc Lemieux - Newtown CT, US Weimin Liu - Sandy Hook CT, US Bryan McKibben - New Milford CT, US Craig Andrew Miller - Norwalk CT, US Neil Moss - Ridgefield CT, US Matt Aaron Tschantz - Newtown CT, US Zhaoming Xiong - Brookfield CT, US Hui Yu - New Milford CT, US Yang Yu - Danbury CT, US
Assignee:
Boehringer Ingelheim International GmbH - Ingelheim am Rhein
Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
A method for producing T cells expressing a chimeric antigen receptor (CAR-T cells), comprising: (i) culturing CAR-T cells in a medium comprising lenalidomide or a derivative thereof to produce CAR-T cells, and optionally (ii) administering the CAR-T cells to a subject in need of the treatment.
- Zug, CH Demetrios Kalaitzidis - Cambridge MA, US Siyuan Tan - Cambridge MA, US Hui Yu - Cambridge MA, US
International Classification:
C12N 15/90 C12N 15/11 C12N 9/22 C12N 5/0783
Abstract:
Aspects of the present disclosure relate to methods for manufacturing genetically engineered T cells expressing a chimeric antigen receptor (CAR) that provide several improvements over conventional manufacturing methods, thereby enabling production of a robust supply of clinically useful CAR T-cell therapies.
Dr. Yu graduated from the Bethune Med Univ, Changchun City, Jilin, China in 1986. She works in Mineola, NY and specializes in Neurology and Neuromuscular Medicine. Dr. Yu is affiliated with Winthrop University Hospital.
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Education:
Baruch College/CUNY New York, NY 2013 to 2016 Bachelor of Business Administration in Human Resource ManagementColorado Mountain College Dillon, CO 2011 to 2013 Associate of Arts