Hui L Zheng

US Patent:

6452065, Sep 17, 2002

Filed:

May 14, 1998

Appl. No.:

09/078871

Inventors:

Hui Zheng - Edison NJ
Ping Jiang - Trenton NJ
Su Qian - Sayreville NJ
Leonardus H. T. Van Der Ploeg - Scotch Plains NJ
Philip Chun-Ying Wong - Timonium MD
Sangram S. Sisodia - Chicago IL

Assignee:

Merck Co., Inc. - Rahway NJ
Johns Hopkins University - Baltimore NJ

International Classification:

A01K 6700

US Classification:

800 12, 3 18, 3 22, 3 25, 435 29, 435354

Abstract:

The present invention relates to a transgenic non-human animal embryo lacking native presenilin 1 and a transgenic non-human animal having only a non-native presenilin 1. The transgenic animals and cells derived therefrom can be used in the study of the expression pattern, activity and modulators of presenilin 1, in the study of the role of presenilin 1 in Alzheimers Disease and in the study of disorders of the central nervous system.

US Patent:

58248374, Oct 20, 1998

Filed:

Apr 22, 1996

Appl. No.:

8/571983

Inventors:

Howard Y. Chen - Westfield NJ
Kathryn J. Hofmann - Collegeville PA
Leonardus H. T. Van Der Ploeg - Scotch Plains NJ
Alan R. Shaw - Doylestown PA
Myrna E. Trumbauer - Yardley PA
Hui Zheng - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 4900
C12N 518
C12N 1509
C12N 1516

US Classification:

800 2

Abstract:

A transgenic mouse has been prepared that expresses a human interluekin-1. beta. transgene. Expression of the transgene is mediated by a mouse metallothionein promoter. As a result of the expression of this transgene, the mouse has inflammation of its kidney and liver. The claimed animals are useful as screening tools for agents that are potentially useful for treating inflammation.

US Patent:

6211428, Apr 3, 2001

Filed:

Apr 28, 1997

Appl. No.:

8/793558

Inventors:

Howard Y. Chen - Westfield NJ
Robert P. Heavens - Harlow, GB
Dalip J. S. Sirinathsinghji - Harlow, GB
David W. Smith - Harlow, GB
Myrna E. Trumbauer - Yardley PA
Leonardus H. T. Van Der Ploeg - Scotch Plains NJ
Aurawan Vongs - Sewell NJ
Hui Zheng - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A01K 6700
A01K 67027
A01K 67033
G01N 3300

US Classification:

800 13

Abstract:

Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine. These transgenic non-human mammals can be assays systems for determining compounds which are effective in modulating production of human amyloid precursor protein in brain and in isolated neuronal cells. Specifically exemplified are transgenic mice whose genome comprises a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine operably linked to a Thy-1 promoter. The mice are shown to produce the APP-FAD variant in their brains by mRNA and protein assays.

US Patent:

61879924, Feb 13, 2001

Filed:

Mar 11, 1999

Appl. No.:

9/266475

Inventors:

Hui Zheng - Rahway NJ
Howard Y. Chen - Rahway NJ
Myrna E. Trumbauer - Rahway NJ
Leonardus H. T. van der Ploeg - Rahway NJ
Guy Seabrook - Harlow, GB
Dalip Sirinathsinghji - Harlow, GB

Assignee:

Merck & co., Inc. - Rahway NJ
Merck Frosst Canada & Co. - Kirkland

International Classification:

A01K 6700
A01K 67027
G01N 3300
C12N 1500
C12N 508

US Classification:

800 12

Abstract:

The present invention relates to a transgenic nonhuman animal lacking native amyloid precursor protein. The transgenic mouse of the invention may be used in the study of Alzheimer's Disease and disorders involving the central nervous system.