Iain W. Duncan - Seattle WA, US Edward A. Kesicki - Bothell WA, US Carl G. Osborne - Jacksonville FL, US William D. Schwieterman - Mobile AL, US Irina Jacobson - Sammamish WA, US
Assignee:
NeuMedics - Seattle WA
International Classification:
A61K 31/536 A61K 31/423
US Classification:
514468, 514471, 514375
Abstract:
The present disclosure is directed to compositions and methods which utilize the tetracycline scaffold, preferably the scaffold of tetracycline or minocycline, and which significantly lack antibiotic activity. The compounds have neuroprotective attributes without interfering with the drugs capacity to pass through the blood brain barrier. These compounds have neuroprotective activity because of their inhibition of neuronal cell cycle progression. The compounds are characterized in part by a fifth ring joining positions 9 and 10.
Process For Manufacturing Bulk Solutions And A Lyophilized Pure Alpha-Aztreonam Lysinate
Alan Montgomery - Medina WA, US Iain Duncan - Seattle WA, US Peter Carbonaro - Sammanish WA, US
International Classification:
A61L009/04 A61K009/14
US Classification:
424046000, 514177000
Abstract:
A process for manufacturing bulk solutions and lyophilized α-aztreonam lysinate for large scale production of an inhalable aztreonam. A purified α-aztreonam lysinate for inhalation. Dry powder or lyophilized α-aztreonam lysinate composition for dry powder or aerosol inhalation.
Pharmaceutical Compositions Of Ibuprofen And Famotidine
Stable pharmaceutical compositions of famotidine and ibuprofen in a single unit dosage form are disclosed herein. In some embodiments, the ibuprofen is in direct physical contact with the famotidine.
- Seattle WA, US Adalbert Jarzyna - Seattle WA, US Iain Duncan - Seattle WA, US
Assignee:
AVM Biotechnology, LLC - Seattle WA
International Classification:
A61K 47/02 A61K 31/573 A61K 47/18
Abstract:
This invention relates to aqueous pharmaceutical formulations comprising a glucocorticoid. These have been formulated to contain high concentrations of glucocorticoid and reduced levels of preservatives.
Direct Hydraulic Rapid Response Module Apparatus And Method
- Houston TX, US Iain G. Duncan - Houston TX, US Kevin Masterson - Houston TX, US
Assignee:
FMC Technologies, Inc. - Houston TX
International Classification:
E21B 33/035 F15B 1/04 F15B 13/02 E21B 34/04
Abstract:
An apparatus, fixed or recoverable to control a remote device includes a valve assembly having a cylinder, a piston dividing the cylinder into a first hydraulic chamber and a second hydraulic chamber, a spring to bias the piston toward the first hydraulic chamber, and a linkage to connect the piston to the remote device, a quick-vent valve assembly comprising an inlet connected to a hydraulic source, an outlet connected to the first hydraulic chamber, and a vent port, wherein the quick-vent valve assembly is configured to discharge fluid from the outlet to the vent when a pressure of the hydraulic source connected to the inlet drops below a threshold value, and a vent line connecting the vent port of the quick-vent valve assembly to a hydraulic accumulator.
Pharmaceutical Compositions Of Ibuprofen And An H2 Receptor Antagonist
Pharmaceutical compositions of a Hreceptor antagonist and ibuprofen are provided herein. The compositions comprise, e.g., a core and a shell separated by a barrier layer, bilayered or trilayered compositions, or liquid formulations. Also provided are methods of making the pharmaceutical compositions, and methods of treatment comprising administering the pharmaceutical compositions. Also provided is a method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which a pharmaceutical composition comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of an HRA, such as famotidine, is administered three times per day