Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.
- Washington DC, US Milton L. Brown - Brookeville MD, US Robert Clarke - Rockville MD, US Jacqueline Smith - Bowie MD, US
Assignee:
GEORGETOWN UNIVERSITY - Washington DC
International Classification:
A61K 31/4439
Abstract:
Small molecule inhibitors of XBP1 splicing by IRE1α are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.
Abnormal Vaginal Bleeding Candidiasis of Vulva and Vagina Complicating Pregnancy or Childbirth Diabetes Mellitus Complicating Pregnancy or Birth Endometriosis
Languages:
Arabic English
Description:
Dr. Smith graduated from the Medical University of South Carolina College of Medicine in 2008. She works in Shelton, WA and 1 other location and specializes in Obstetrics & Gynecology and Reproductive Endocrinology. Dr. Smith is affiliated with Hackensack UMC At Pascack Valley, Hackensack University Medical Center Mountainside, Mason General Hospital and Saint Marys General Hospital.
Dr. Smith graduated from the University of Kansas School of Medicine in 1993. She works in Liberty, MO and specializes in Pulmonary Disease. Dr. Smith is affiliated with Liberty Hospital.
Jacqueline E Smith MD PA 4101 NW 4 St STE 409, Fort Lauderdale, FL 33317 (954)3219555 (phone), (954)3219557 (fax)
Education:
Medical School Albert Einstein College of Medicine at Yeshiva University Graduated: 1992
Conditions:
Cataract Diabetic Retinopathy Glaucoma Keratitis
Languages:
English Spanish
Description:
Dr. Smith graduated from the Albert Einstein College of Medicine at Yeshiva University in 1992. She works in Plantation, FL and specializes in Ophthalmology. Dr. Smith is affiliated with Broward Health Medical Center.
UPMC Hamot Bariatric Surgery Center 300 State St STE 400A, Erie, PA 16507 (814)8776997 (phone), (814)8776356 (fax)
Languages:
English
Description:
Ms. Smith works in Erie, PA and specializes in Bariatrician. Ms. Smith is affiliated with Healthsouth Rehabilitation Hospital Erie and UPMC Hamot Medical Center.
Womens Medical Group Of The CarolinasGibbs Cancer Center & Research Institute Pelham 2759 S Hwy 14, Greer, SC 29650 (864)8499700 (phone), (864)8499710 (fax)
Languages:
English
Description:
Ms. Smith works in Greer, SC and specializes in Hematology/Oncology. Ms. Smith is affiliated with Spartanburg Regional Medical Center.
Name / Title
Company / Classification
Phones & Addresses
Jacqueline Smith Marketing Executive
Fort Meade Community Cu Credit Unions, Federally Chartered
4471 Redwood Rd # B, Fort George G Meade, MD 20755
Jan 2013 to Nov 2013 Assistant ManagerBagby Pizza Company Baltimore, MD May 2011 to Nov 2012 CashierTie Breakers Greenville, NC Feb 2010 to Apr 2010 ServerTripp's Restaurant Greenville, NC May 2008 to Aug 2008 Hostess
Education:
East Carolina University College of Human Ecology Greenville, NC May 2012 Bachelor of Science in Hospitality Management
2012 to 2000 AppleCare Technical AdvisorPFS WEB Plano, TX 2011 to 2012 Customer Relationship Management (CRM) Team LeadNORDSTROM Dallas, TX 2006 to 2011 Personal Stylist/SalesPAYCHEX, INC Irving, TX 2008 to 2009 Client Service Specialist
Education:
Southern New Hampshire University NH 2012 to 2015 BA in Public Relations & Social Media MarketingUniversity of Texas at Arlington Arlington, TX 1999 to 2002 Public Relations/Marketing
Jun 2011 to Present Specialty Account Representative/ Customer Service Team LeadCPR Heartplace Dallas, TX Jun 2002 to May 2011 Patient Account RepresentativeDallas Nephrology Associates Dallas, TX Jul 1993 to Jan 2002 Patient Account Representative/ Customer Service Representative
LabCorp Irving, TX 2009 to 2009 Phlebotomy TechnicianSix weeks of training through Central Texas College
2002 to 2002 Phlebotomy Technician
Education:
Everest College Arlington, TX 2008 to 2000 CMA in Certified Medical AssistantEverest College Arlington, TX 2008 to 2009 CPTCentral Texas College Killeen, TX 2002Ellison High School Killeen, TX
1989 to 2007 Member of Child Study TeamWillingboro Board of Education Willingboro, NJ Oct 1974 to 1982 School Social WorkerChild Welfare Philadelphia Department of Public Welfare Philadelphia, PA Sep 1967 to 1969 Social Worker
Education:
Rutgers University 1976 to 1977 EducationMorgan State University Baltimore, MD May 1965 B.A. in Sociology
Department of the Army - ESS (2010) Civilian Expeditionary Workforce - Education Services Officer (2012-2013) Department of the Navy-USMC - Guidance Counselor (2009-2010)
Education:
Bowie State University - MA Counseling Psych, University of California - Davis - BA Psychology, Cottey College, Vanden High School
Monitcello College - Mom, Business Owner, Activist
Education:
George Wythe University
About:
Founder of The STAR Forum, a 9.12 group to help educate and advocate Constitutional principles to end the aristocracy in Washington D.C. We must Save The American Republic, by being deeply educated i...
University of North Carolina at Chapel Hill - Biology, Psychology, Chemistry, University of North Carolina at Chapel Hill - Medicine
Tagline:
Omnia vincit amor :)
Jacqueline Smith
Work:
'Unemployed' - Creator/Founder (7)
Education:
Monmouth University - Anthropology
About:
I am currently working on my own website which provides a free social service to those in need of resume, career, and life advice. I am enthusiastic about the site, social media, and helping people. &...
Tagline:
Helping people reach their career and life goals
Bragging Rights:
Studied abroad at Kingston University back in 2005.
Jacqueline Smith
Work:
Nadeau - Furniture with a Soul - Sales (2011)
Education:
University of St. Thomas - English
Tagline:
She's got everything she needs, she's an artist, and she don't look back.
Jacqueline Smith
Work:
Gordon Jewish Community Center - Swim Instructor (4) Berklee College of Music - Temp (2-2011)
Education:
Berklee College of Music - Professional Music
Tagline:
"She felt as if she were brimming, always producing and hoarding more love inside her. But there was no..."
Jacqueline Smith
Lived:
Baltimore MD Rye NY
Education:
Loyola University Maryland - History
About:
Live to the fullest.laugh out loud.love like you've never been hurt.
Jacqueline Smith, a quality control inspector at the Ford-Mazda Flat Rock plant, also attended the ceremony and said, "I believe in Martin Luther King and what he's done for our people and when I say our people I mean all people.
likely challenger is Rep. Jason Chaffetz, R-Utah, who has privately told Republican insiders that he will jump into the race later this year. Kirkham and Jacqueline Smith, another Utah tea party leader, said Chaffetzs record will also be scrutinized but they are partial to the two-term congressman.
Its time to make sure that Washington, D.C., is not deciding who our senators are, especially other senators deciding who our senators are, said Jacqueline Smith of Park City, Utah. This is our decision, and all we have to do is to let our senators know.
"It could be businesses, families, anybody who's inspired to have a group out here," said Jacqueline Smith, entertainment chair for the relay. "Each individual raises about $100. The biggest team raised $22,000." One team raffled off a signed Aaron Rodgers jersey for nearly $3,000.