Jacqueline Suzette Wyatt

US Patent:

7067497, Jun 27, 2006

Filed:

Jan 2, 2002

Appl. No.:

10/038335

Inventors:

Ronnie C. Hanecak - San Clemente CA, US
Kevin P. Anderson - Carlsbad CA, US
C. Frank Bennett - Carlsbad CA, US
Ming-Yi Chiang - San Diego CA, US
Vickie L. Brown-Driver - Solana Beach CA, US
David J. Ecker - Encinitas CA, US
Timothy A. Vickers - Oceanside CA, US
Jacqueline R. Wyatt - Encinitas CA, US

Assignee:

ISIS Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 21/04
A61K 31/7115
A61K 31/712
A61K 31/7125

US Classification:

514 44, 536 231, 536 245, 536 252

Abstract:

Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided, as are methods for inhibiting the division of a malignant mammalian cell and for modulating the effects of cellular aging.

US Patent:

20030144242, Jul 31, 2003

Filed:

Feb 21, 2003

Appl. No.:

10/371474

Inventors:

Donna Ward - Murrieta CA, US
William Gaarde - Carlsbad CA, US
Brett Monia - La Costa CA, US
Jacqueline Wyatt - Encinitas CA, US

International Classification:

A61K048/00
C12Q001/68
C07H021/04

US Classification:

514/044000, 536/023200, 435/006000, 435/375000

Abstract:

Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.

US Patent:

20040033976, Feb 19, 2004

Filed:

Jun 13, 2003

Appl. No.:

10/380127

Inventors:

Donna Ward - Murrieta CA, US
William Gaarde - Carlsbad CA, US
Brett Monia - Encinitas CA, US
Jacqueline Wyatt - Encinitas CA, US

International Classification:

A61K048/00

US Classification:

514/044000

Abstract:

Antisense compounds, compositions and methods are provided for modulating the expression of MEKK3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK3. Methods of using these compounds for modulation of MEKK3 expression and for treatment of diseases associated with expression of MEKK3 are provided.

US Patent:

20070015723, Jan 18, 2007

Filed:

May 17, 2006

Appl. No.:

11/436901

Inventors:

Ronnie Hanecak - San Clemente CA, US
Kevin Anderson - Carlsbad CA, US
C. Bennett - Carlsbad CA, US
Ming-Yi Chiang - San Diego CA, US
Vickie Brown-Driver - Solana Beach CA, US
David Ecker - Encinitas CA, US
Timothy Vickers - Oceanside CA, US
Jacqueline Wyatt - Sundance WY, US

International Classification:

A61K 48/00

US Classification:

514044000, 514081000

Abstract:

Modified oligonucleotides having a conserved Gsequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus or phospholipase Aor to modulate the telomere length of a chromosome are provided. Gquartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase Aare also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.

US Patent:

20110124715, May 26, 2011

Filed:

Aug 4, 2010

Appl. No.:

12/849886

Inventors:

Ronnie C. Hanecak - San Clemente CA, US
Kevin P. Anderson - Carlsbad CA, US
C. Frank Bennett - Carlsbad CA, US
Ming-Yi Chiang - San Diego CA, US
Vickie L. Brown-Driver - Solana Beach CA, US
David J. Ecker - Encinitas CA, US
Timothy Vickers - Oceanside CA, US
Jacqueline R. Wyatt - Sundance WY, US

International Classification:

A61K 31/7088
C12N 7/00
A61P 31/16
A61P 31/18
A61P 31/22

US Classification:

514 44 R, 4352351

Abstract:

Modified oligonucleotides having a conserved Gsequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus are provided. Gquartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases are also provided.

US Patent:

59524901, Sep 14, 1999

Filed:

Jun 12, 1995

Appl. No.:

8/403888

Inventors:

Ronnie C. Hanecak - San Clemente CA
Kevin P. Anderson - Carlsbad CA
C. Frank Bennett - Carlsbad CA
Ming-Yi Chiang - Laguna Hills CA
Vickie L. Brown-Driver - San Diego CA
David J. Ecker - Leucadia CA
Timothy A. Vickers - Oceanside CA
Jacqueline R. Wyatt - Carlsbad CA
Jean Louis Imbach - Montpellier, FR

Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 2104

US Classification:

536 245

Abstract:

Modified oligonucleotides having a conserved G. sub. 4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A. sub. 2 or to modulate the telomere length of a chromosome are provided. G. sub. 4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnosis and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A. sub. 2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to plat a role in the aging process of a cell and in control of malignant cell growth.