The Invention of Photography and Its Impact on Learning: Photographs from Harvard University and Radcliffe College and from the Collection of Harrison D. Horblit
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Us Patents
Pyrazolo[3,4-B]Quinolines And Their Use As Antiviral Agents
Malcolm R. Bell - East Greenbush NY James H. Ackerman - Albany NY
Assignee:
Sterling Drug Inc. - New York NY
International Classification:
A61K 31415 A61K 31435 C07D41300 C07D47100
US Classification:
514293
Abstract:
Pyrazolo[3,4-b]quinolines having the formula ##STR1## where R is hydrogen, hydroxy or alkoxy; R. sub. 2 is halogen, cyano, carbamyl, carboxy, lower-alkylcarbonyl, amino or aminomethyl; and R. sub. 1 is hydrogen or selected substituents as defined herein, are useful as antiviral agents and/or as vasodilators.
Dennis J. Hlasta - Lower Salford Township, Montgomery County PA James H. Ackerman - Albany NY Albert J. Mura - Rochester NY Ranjit C. Desai - Towamencin Township, Montgomery County PA
Assignee:
Sterling Winthrop Inc. - New York NY
International Classification:
A61K 31425 C07D27506 C07D21316 C07D23970
US Classification:
514373
Abstract:
Compounds having the structural formula ##STR1## which inhibit the enzymatic activity of proteolytic enzymes, and processes for preparation thereof, method of use thereof in treatment of degenerative diseases and pharmaceutical compositions thereof are disclosed.
3-Amino-2,4,6-triiodobenzoic acids optionally substituted in the 5-position by amino or carboxy or a derivative thereof react with dibasic acid anhydrides to give the corresponding cyclic imides (A), which can be hydrolyzed to the corresponding anilic acids (B). The latter can be further alkylated on the anilide nitrogen atom. Compounds A and B are useful as cholecystographic and urographic agents.
3-Amino-2,4,6-triiodobenzoic acids optionally substituted in the 5-position by amino or carboxy or a derivative thereof react with dibasic acid anhydrides to give the corresponding cyclic imides (A), which can be hydrolyzed to the corresponding anilic acids (B). The latter can be further alkylated on the anilide nitrogen atom. Compounds A and B are useful as cholecystographic and urographic agents.
Dennis J. Hlasta - Lower Salford Township, Montgomery County PA James H. Ackerman - Albany NY Albert J. Mura - Rochester NY Ranjit C. Desai - Towamencin Township, Montgomery County PA
Assignee:
Sterling Winthrop Inc. - New York NY
International Classification:
A61K 31425 A61K 31535 C07D41714 C07D41712
US Classification:
514373
Abstract:
Compounds having the structural formula ##STR1## which inhibit the enzymatic activity of proteolytic enzymes, and processes for preparation thereof, method of use thereof in treatment of degenerative diseases and pharmaceutical compositions thereof are disclosed.
Michael Hudak, Kristen Saurez, Alisia Clyde, John Andermo, Ron Manners, Janice Zuppa, Bob Bob, Rebecca Baum, Sharlee King, Sandra Quevedo, Raul Patel, Jen Basmagy