James M Angelastro

US Patent:

8158420, Apr 17, 2012

Filed:

Oct 22, 2004

Appl. No.:

10/971483

Inventors:

Lloyd A Greene - Larchmont NY, US
James M Angelastro - Davis CA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

C12N 5/02
C12N 5/04
C12N 5/00
G03C 5/16

US Classification:

435376, 435325, 435377, 430350

Abstract:

The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods. Also provided are methods for diagnosing tumors, for assessing the efficacy of therapy to treat tumors and for assessing the prognosis of a subject who has a neural tumor.

US Patent:

20050164384, Jul 28, 2005

Filed:

Mar 24, 2004

Appl. No.:

10/809312

Inventors:

Lloyd Greene - Larchmont NY, US
James Angelastro - Davis CA, US

International Classification:

C12N005/08

US Classification:

435368000

Abstract:

The present invention provides methods for promoting or suppressing differentiation of neural stem/progenitor cells, for producing differentiated neural cells, and for isolating/purifying differentiated neural cells. Also provided are differentiated neural cells, cell populations and transgenic animals comprising same, and uses of same. The present invention further provides methods for treating nervous tissue degeneration, and for identifying an agent for use in treating nervous tissue degeneration. Additionally, the present invention provides a therapeutic composition, and methods for treating neural tumors using same. The present invention further provides methods for identifying agents which inhibit ATF5, agents identified by these methods, and uses of same. Also provided are methods for diagnosing neural tumors, for assessing the efficacy of therapy to treat neural tumors, and for assessing the prognosis of a subject who has a neural tumor. Finally, the present invention provides a kit for use in detecting a neural tumor.

US Patent:

20070092495, Apr 26, 2007

Filed:

Sep 20, 2006

Appl. No.:

11/524162

Inventors:

Lloyd Greene - Larchmont NY, US
James Angelastro - Davis CA, US

International Classification:

A61K 35/30
C12N 5/08

US Classification:

424093700, 435368000

Abstract:

The present invention provides methods for promoting or suppressing differentiation of neural stem/progenitor cells, for producing differentiated neural cells, and for isolating/purifying differentiated neural cells. Also provided are differentiated neural cells, cell populations and transgenic animals comprising same, and uses of same. The present invention further provides methods for treating nervous tissue degeneration, and for identifying an agent for use in treating nervous tissue degeneration. Additionally, the present invention provides a therapeutic composition, and methods for treating neural tumors using same. The present invention further provides methods for identifying agents which inhibit ATF5, agents identified by these methods, and uses of same. Also provided are methods for diagnosing neural tumors, for assessing the efficacy of therapy to treat neural tumors, and for assessing the prognosis of a subject who has a neural tumor. Finally, the present invention provides a kit for use in detecting a neural tumor.

US Patent:

20090018096, Jan 15, 2009

Filed:

Apr 3, 2008

Appl. No.:

12/062178

Inventors:

Lloyd A. Greene - Larchmont NY, US
James M. Angelastro - Davis CA, US

International Classification:

A61K 31/7105
C12N 5/00
A61P 35/00

US Classification:

514 44, 435377

Abstract:

The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods. Also provided are methods for diagnosing tumors, for assessing the efficacy of therapy to treat tumors and for assessing the prognosis of a subject who has a neural tumor. Finally, the present invention provides a kits for use in detecting and treating tumors.

US Patent:

20120238462, Sep 20, 2012

Filed:

Mar 7, 2012

Appl. No.:

13/414427

Inventors:

Lloyd A. Greene - Larchmont NY, US
James M. Angelastro - Davis CA, US

International Classification:

G01N 33/574
C40B 30/04
C12Q 1/68

US Classification:

506 9, 435 792, 435 71, 435 611

Abstract:

The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5.

US Patent:

20160046686, Feb 18, 2016

Filed:

Aug 19, 2015

Appl. No.:

14/830194

Inventors:

- New York NY, US
James Angelastro - Davis CA, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

C07K 14/47

Abstract:

The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.