James M Bishop

US Patent:

6372445, Apr 16, 2002

Filed:

Mar 7, 2000

Appl. No.:

09/521452

Inventors:

Kenneth A. Davis - Woodside CA
Barnaby Abrams - San Carlos CA
James A. Bishop - Santa Cruz CA

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

G01N 3353

US Classification:

435 724, 435 6, 435 75, 435 405, 436501, 436532, 436546, 436800, 5303913, 5303915, 5303919, 530402, 530403

Abstract:

The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The second moiety may be one member of a specific binding pair. The invention is based in part on the surprising result that when a chromophore is used as a âcross-linkerâ between a signal-enhancing agent and a member of a binding pair (essentially being buried between the two), the signal of the chromophore is not quenched. This arrangement, wherein the chromophore acts simultaneously as a cross-linker and a detectable compound, provides significant advantages over previously known compounds since the chromophore is sterically hindered from interacting non-specifically with substances present in the test systems. Moreover, the chromophore can be used as a cross-linker with little or no loss of detectable signal.

US Patent:

7030981, Apr 18, 2006

Filed:

Aug 9, 2002

Appl. No.:

10/215518

Inventors:

James K. Bishop - Berkeley CA, US
Christopher K. Guay - San Francisco CA, US

Assignee:

The Regentsof the University of California - Oakland CA

International Classification:

G01J 4/00

US Classification:

356368, 356365

Abstract:

A method and apparatus for measuring birefringent particles is provided comprising a source lamp, a grating, a first polarizer having a first transmission axis, a sample cell and a second polarizer having a second polarization axis. The second polarizer has a second polarization axis that is set to be perpendicular to the first polarization axis, and thereby blocks linearly polarized light with the orientation of the beam of light passing through the first polarizer. The beam of light passing through the second polarizer is measured using a detector.

US Patent:

20100266156, Oct 21, 2010

Filed:

Nov 7, 2008

Appl. No.:

12/742395

Inventors:

James K.B. Bishop - Berkeley CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G06K 9/00
G01J 4/04
H04N 7/18

US Classification:

382100, 356364, 348135, 348E07085

Abstract:

A robotic optical sedimentation recorder is described for the recordation of carbon flux in the oceans wherein both POC and PIC particles are captured at the open end of a submersible sampling platform, the captured particles allowed to drift down onto a collection plate where they can be imaged over time. The particles are imaged using three separate light sources, activated in sequence, one source being a back light, a second source being a side light to provide dark field illumination, and a third source comprising a cross polarized light source to illuminate birefringent particles. The recorder in one embodiment is attached to a buoyancy unit which is capable upon command for bringing the sedimentation recorder to a programmed depth below the ocean surface during recordation mode, and on command returning the unit to the ocean surface for transmission of recorded data and receipt of new instructions. The combined unit is provided with its own power source and is designed to operate autonomously in the ocean for extended periods of time.

US Patent:

61334294, Oct 17, 2000

Filed:

Oct 3, 1997

Appl. No.:

8/943491

Inventors:

Kenneth A. Davis - Woodside CA
James E. Bishop - Santa Cruz CA
Barnaby Abrams - San Carlos CA

Assignee:

Becton Dickinson and Company - Franklin Lakes NJ

International Classification:

G01N 33533
C07K 1644

US Classification:

5303915

Abstract:

The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The second moiety may be one member of a specific binding pair. The invention is based in part on the surprising result that when a chromophore is used as a "cross-linker" between a signal-enhancing agent and a member of a binding pair (essentially being buried between the two), the signal of the chromophore is not quenched. This arrangement, wherein the chromophore acts simultaneously as a cross-linker and a detectable compound, provides significant advantages over previously known compounds since the chromophore is sterically hindered from interacting non-specifically with substances present in the test systems. Moreover, the chromophore can be used as a cross-linker with little or no loss of detectable signal.