James David Bishop

US Patent:

20220409627, Dec 29, 2022

Filed:

Dec 2, 2020

Appl. No.:

17/781289

Inventors:

- Basel, CH
Brian A. LORTIE - Paoli PA, US
James P. BISHOP - Cary NC, US
Kenneth S. KILGORE - Berwyn PA, US
William T. SYMONDS - Cary NC, US
Stephen A. WRING - South Boston VA, US
Jayne E. HASTEDT - San Carlos CA, US
Katelyn R. CRIZER - Chapel Hill NC, US
Michelle PALACIOS - Garner NC, US

International Classification:

A61K 31/5415
A61P 11/00
A61K 9/00
A61K 47/26
C07K 16/28

Abstract:

A method for treating an inflammatory disorder of the lower airways in a human subject in need thereof is described, including administering an effective amount of anakinra directly to the lower airways in the human subject; where the effective amount of anakinra is from about 0.1 mg to about 200 mg per day; and where the inflammatory disorder is selected from the group consisting of a toxic-inhalation lung injury, pulmonary langerhans cell histiocytosis, non-cystic fibrosis bronchiectasis, diffuse panbronchiolitis, acute respiratory distress syndrome (ARDS), reactive airways dysfunction syndrome (RADS), bronchiolitis obliterans organizing pneumonia and pneumonitis.