James M Bustillo

US Patent:

6960488, Nov 1, 2005

Filed:

Jun 29, 1999

Appl. No.:

09/342348

Inventors:

Timothy J. Brosnihan - Berkeley CA, US
James Bustillo - Castro Valley CA, US
William A. Clark - Fremont CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

H01L021/00
G01P015/125

US Classification:

438 52, 438 50, 7351432

Abstract:

A microfabricated device having a high vertical aspect ratio and electrical isolation between a structure region and a circuit region. The device may be fabricated on a single substrate and may include electrical interconnections between the structure region and the circuit region. The device includes a substrate and an isolation trench surrounding a structure region in the substrate. The isolation trench includes a lining of a dielectric insulative material. A plurality of microstructure elements are located in the structure region and are laterally anchored to the isolation trench.

US Patent:

7948015, May 24, 2011

Filed:

Dec 14, 2007

Appl. No.:

12/002291

Inventors:

Jonathan M. Rothberg - Guilford CT, US
Wolfgang Hinz - New Haven CT, US
Kim L. Johnson - Carlsbad CA, US
James Bustillo - Castro Valley CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

G01N 27/403

US Classification:

257253, 257E2308, 438 10

Abstract:

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e. g. , ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

US Patent:

8263336, Sep 11, 2012

Filed:

May 31, 2011

Appl. No.:

13/149331

Inventors:

Jonathan M Rothberg - Guilford CT, US
James M. Bustillo - Castro Valley CA, US
Mark J. Milgrew - Branford CT, US
Jonathan C. Schultz - Oxford MA, US
David Marran - Durham CT, US
Todd M Rearick - Cheshire CT, US
Kim L. Johnson - Carlsbad CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

C12Q 1/68
C12M 1/00
C12M 1/34
C12M 3/00
G01N 27/403

US Classification:

435 61, 4352831, 4352872, 257253

Abstract:

Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

US Patent:

8264014, Sep 11, 2012

Filed:

Feb 2, 2011

Appl. No.:

13/019463

Inventors:

Jonathan M. Rothberg - Guilford CT, US
Wolfgang Hinz - New Haven CT, US
Kim L. Johnson - Carlsbad CA, US
James Bustillo - Castro Valley CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

G01N 27/403

US Classification:

257253, 257E2308, 438 10

Abstract:

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e. g. , ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

US Patent:

8269261, Sep 18, 2012

Filed:

Feb 8, 2011

Appl. No.:

13/022694

Inventors:

Jonathan M. Rothberg - Guilford CT, US
Wolfgang Hinz - New Haven CT, US
Kim L. Johnson - Carlsbad CA, US
James Bustillo - Castro Valley CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

G01N 27/403

US Classification:

257253, 257E2308, 438 10

Abstract:

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e. g. , ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

US Patent:

8306757, Nov 6, 2012

Filed:

Mar 10, 2010

Appl. No.:

12/721458

Inventors:

Jonathan M. Rothberg - Guilford CT, US
Wolfgang Hinz - New Haven CT, US
Kim L. Johnson - Carlsbad CA, US
James M. Bustillo - Castro Valley CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

C12Q 1/68
H01L 29/739

US Classification:

702 20, 257253, 257E293, 327427, 327434, 438 10, 4352884

Abstract:

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e. g. , ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

US Patent:

8313625, Nov 20, 2012

Filed:

Feb 28, 2011

Appl. No.:

13/036673

Inventors:

Jonathan M. Rothberg - Guilford CT, US
Wolfgang Hinz - New Haven CT, US
Kim L. Johnson - Carlsbad CA, US
James Bustillo - Castro Valley CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

G01N 27/414

US Classification:

204406, 257253

Abstract:

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e. g. , ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

US Patent:

8313639, Nov 20, 2012

Filed:

Feb 28, 2011

Appl. No.:

13/036759

Inventors:

Jonathan M. Rothberg - Guilford CT, US
Wolfgang Hinz - New Haven CT, US
Kim L. Johnson - Carlsbad CA, US
James Bustillo - Castro Valley CA, US

Assignee:

Life Technologies Corporation - Carlsbad CA

International Classification:

C12Q 1/25
G01N 27/414

US Classification:

2057935, 205792, 257253, 435 61

Abstract:

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e. g. , ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.