James L Clements

US Patent:

61946338, Feb 27, 2001

Filed:

Jan 26, 1998

Appl. No.:

9/013687

Inventors:

Gary A. Koretzky - North Liberty IA
James L. Clements - Iowa City IA
Roger Williamson - Iowa City IA

Assignee:

University of Iowa Research Foundation - Iowa City IA

International Classification:

A01K 6700
G01N 3300
C12N 1500

US Classification:

800 18

Abstract:

A nonhuman animal having somatic and germ cells in which at least one allele of an endogenous SLP-76 gene is functionally disrupted is provided. The animal may be heterozygous or, more preferably, homozygous for the SLP-76 gene disruption and is preferably a mouse. In homozygous animals, the percentage of peripheral T cells is substantially decreased compared to wildtype animals, whereas the percentage of B cells and macrophages in the periphery is substantially normal, indicating that SLP-76 disruption causes a profound block in T cell development. The animals of the invention can be used, for example, as controls to evaluate the efficacy of SLP-76 inhibitors and to identify disease conditions that can be treated with SLP-76 inhibitors. A transgenic nonhuman animal having a functionally disrupted endogenous SLP-76 gene but which has been reconstituted with an exogenous SLP-76 transgene (e. g. , a human SLP-76 gene or a SLP-76 gene whose expression in targeted to a particular cell population) is also provided.

US Patent:

20210347763, Nov 11, 2021

Filed:

Dec 8, 2020

Appl. No.:

17/114699

Inventors:

- Buffalo NY, US
Sameer URGAONKAR - Williamsville NY, US
James Lindsay CLEMENTS - East Aurora NY, US

International Classification:

C07D 403/14
C07D 403/12
A61P 37/08
A61P 37/02

Abstract:

The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

US Patent:

20200071305, Mar 5, 2020

Filed:

Sep 11, 2019

Appl. No.:

16/567300

Inventors:

- Buffalo NY, US
Sameer URGAONKAR - Amherst NY, US
James Lindsay CLEMENTS - East Aurora NY, US

International Classification:

C07D 403/14
A61P 37/02
A61P 37/08
C07D 403/12

Abstract:

The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

US Patent:

20190018573, Jan 17, 2019

Filed:

Jul 13, 2017

Appl. No.:

15/648836

Inventors:

- Armonk NY, US
James V. Clements - Perkasie PA, US
Ryan D. Helmoski - Windom MN, US
Michael J. Casper - Gretna NE, US

International Classification:

G06F 3/0484
G06N 7/00

Abstract:

Provided is a method for automatically identifying a long loading time for a user selection. An initial user input against a selection element for an application running on an electronic device is received. The initial user input is transmitted to a server for processing the initial user input. One or more additional user inputs are received after the server has begun processing the initial user input. Statistical analysis techniques are utilized to determine a selection attempt value. The selection attempt value is compared to a predetermined retry rate criteria. The selection attempt value is determined to satisfy a threshold. An action is performed in response to determining that the selection attempt value satisfies the threshold.

US Patent:

20180278492, Sep 27, 2018

Filed:

Mar 21, 2017

Appl. No.:

15/465214

Inventors:

- ARMONK NY, US
James V. CLEMENTS - Perkasie PA, US
Ryan D. HELMOSKI - Windom MN, US
Naijun YANG - Flushing NY, US

International Classification:

H04L 12/24
H04M 1/02
H04W 4/20
H04L 12/26

Abstract:

A client device (e.g., smart phone) submits scroll log data to a server. The scroll log data comprises time stamps of load start events, load end events and lag events. The server then computes a performance value using the scroll log data and, responsive to the performance value, adjusts a first scroll parameter for use by client devices. The server also transmits the adjusted first scroll parameter to the client device for use in a graphical user interface scroll on an application executing on the client device. The server then transmits data to the client device in response to the client device's use of the adjusted first scroll parameter.

US Patent:

20180265499, Sep 20, 2018

Filed:

Mar 15, 2018

Appl. No.:

15/921890

Inventors:

- Buffalo NY, US
Sameer URGAONKAR - Amherst NY, US
James Lindsay CLEMENTS - East Aurora NY, US

International Classification:

C07D 403/14
C07D 403/12
A61P 37/02
A61P 37/08

Abstract:

The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.