A vehicle wheel splash guard for use on trucks, trailers, and other wheeled or tracked vehicles to reduce dangerous spray and splash. The splash guard is a double-wall construction having inner and outer walls which generally conform to the contour of a tire, covering the top and upper side portions thereof. Elongated apertures in the inner wall provide passages to the inside of the double-wall construction for water thrown off the tire. Said apertures extend in a direction transverse to that of the tire rotation on the top portion and in the direction of tire rotation on the side portions thereof. Baffles inside the double walls drain the water to locations under the vehicle and away from the paths of following tires. The splash guard is molded in one piece from lightweight plastic and may be formed to any shape desired or even inset with de-icing wires.